Wireless implantable micro-stimulation device for high frequency bilateral deep brain stimulation in freely moving mice

Haas, Ria de; Struikmans, Rolf; Plasse, G; Kerkhof, Linda W M van; Brakkee, Jan H.; Kas, Martien; Westenberg, H.G.M.

doi:10.1016/j.jneumeth.2012.05.028

Cited by 51 publications

(45 citation statements)

References 27 publications

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“…In contrast to this, experiments stimulating the relatively large and/or isolated structures such as the hippocampus and fornix employed multiple intracranial stimulation protocols to study cognitive improvement [41,42,43]. Repetitive stimulation of small structures in free-moving rodents may be more practical with a wireless stimulating device to mimic DBS in clinical applications [44]. Whether multiple stimulations or implementing stimulation during the behavioral task (event-related) to the rostral ILN in cognition-compromised animals could elicit more robust cognitive improvement remains to be explored.…”

Section: Discussionmentioning

confidence: 99%

Rostral Intralaminar Thalamic Deep Brain Stimulation Triggered Cortical and Hippocampal Structural Plasticity and Enhanced Spatial Memory

Tsai

Chen²,

Wang³

et al. 2016

Stereotact Funct Neurosurg

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Background/Aims: Rostral intralaminar thalamic nucleus (ILN) has been shown to modulate cognition through indirect connection with the hippocampus and prefrontal cortex. We explored the effects of deep brain stimulation (DBS) to the rostral ILN on spatial memory acquisition, brain neuronal activation and cortical and hippocampal synaptic changes in rats. Methods: The Morris water maze (MWM) task was used to evaluate the spatial memory of the rats. The expression of c-fos, an immediate early gene, was used to identify neural activation in the cerebral cortex and hippocampus. Synaptic changes in the somatosensory cortical and hippocampal neurons were explored with dendritic spine analysis following Golgi-Cox staining. Results: Our results showed that a barrage of DBS to the rostral ILN of normal rats significantly shortened their escape latency in MWM compared with sham-stimulated and untreated control rats. Rats with enhanced spatial memory had more c-fos immunoreactive cells in layer IV of the somatosensory cortex. Layer III cortical and CA1 hippocampal pyramidal neurons showed over 50% increase of dendritic spines, while only the proximal apical dendrites of layer V cortical pyramidal neurons had more dendritic spines. Conclusions: Rostral ILN-DBS activated neurons in the cerebral cortex and triggered cortical and hippocampal structural plasticity in association with spatial memory enhancement.

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Section: Discussionmentioning

confidence: 99%

Rostral Intralaminar Thalamic Deep Brain Stimulation Triggered Cortical and Hippocampal Structural Plasticity and Enhanced Spatial Memory

Tsai

Chen²,

Wang³

et al. 2016

Stereotact Funct Neurosurg

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“…Within the host body, the individual modules of the electrical system can reside intracavity, e.g., within the intestinal, oral, or urinary systems etc., be implanted subcutaneously or deep within the tissues, or be located on the external surfaces of the body [50][51][52]. Hard shell packaging is often used to protect the electronic circuitry, whereas the remainder of the indwelling assembly may also have a soft encapsulation layer [53].…”

Section: General Characteristics Of Implant Systemsmentioning

confidence: 99%

Implantable Devices: Issues and Challenges

2012

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Ageing population and a multitude of neurological and cardiovascular illnesses that cannot be mitigated by medication alone have resulted in a significant growth in the number of patients that require implantable electronic devices. These range from sensors, gastric and cardiac pacemakers, cardioverter defibrillators, to deep brain, nerve, and bone stimulators. Long-term implants present specific engineering challenges, including low energy consumption and stable performance. Resorbable electronics may offer excellent short-term performance without the need for surgical removal. However, most electronic materials have poor bio-and cytocompatibility, resulting in immune reactions and infections. This paper reviews the current situation and highlights challenges for future advancements.

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“…Another example of current interest in neuroscience is the electric microstimulation of deep brain structures. This technique is being investigated in preclinical settings to uncover their functional principles and exploit their full clinical possibilities (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Neurosurgery planning in rodents using a magnetic resonance imaging assisted framework to target experimentally defined networks

Pallarés

Moya

Samper-Belda

et al. 2015

Computer Methods and Programs in Biomedicine

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Wireless implantable micro-stimulation device for high frequency bilateral deep brain stimulation in freely moving mice

Cited by 51 publications

References 27 publications

Rostral Intralaminar Thalamic Deep Brain Stimulation Triggered Cortical and Hippocampal Structural Plasticity and Enhanced Spatial Memory

Rostral Intralaminar Thalamic Deep Brain Stimulation Triggered Cortical and Hippocampal Structural Plasticity and Enhanced Spatial Memory

Implantable Devices: Issues and Challenges

Neurosurgery planning in rodents using a magnetic resonance imaging assisted framework to target experimentally defined networks

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