Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing

Technology Roadmap for Flexible Sensors

“…We envision that future intelligent sensors should possess the following characteristics (Figure ): (1) fully autonomous (closed-loop) operation from stimuli detection and signal processing, to data analysis and feedback, while maintaining communication with operators/users, ,,,− (2) capability to analyze complex sensor signals (multimodal and multiplexed signals, array signals, and sensor networks) to provide accurate and customized analysis of specific situations and to produce actionable feedback, (3) robust performance under non-ideal conditions including tolerance to errors and noise, and adaptability to changing environments, (4) learning capability to refine and improve performance with continued usage, (5) fast response (real-time feedback) with high energy efficiency, and (6) compact, lightweight (and flexible for bio-integration) form factors. These features will empower intelligent sensors to solve complex and unstructured real-world problems efficiently and reliably, while requiring less maintenance and management.…”

“…Innovations in device structural design, system layout and operation, and materials manufacture will bring about more effective solutions to these challenges and form factors that are presently rare ( e.g. , mask, ,,, suture, or bandage). Importantly, to design and to engineer materials and form factors that allow seamless integration with biological tissues, it is essential to understand in detail and in depth the anatomy, physiology, material properties, biological functions, etc .…”

Sustainable Nanomaterials for Biomedical Applications

“…A large surface area to volume and the unique size, shape, and composition-dependent characteristics of nanomaterials make them suitable for various practical applications from biomedical to renewable energy and the environment. In the biomedical field, the scientific revolution of nanotechnology has witnessed the discovery of mRNA vaccines for COVID-19 using lipid nanoparticles [ 1 ], the development of wearable medical devices/sensors [ 2 ], and wireless bandages stimulating wound healing for people living in both urban and rural regions [ 3 ].…”

Ultrasensitive Refractive Index Sensing Based on Hybrid High-Q Metasurfaces

“…Due to the capabilities of user-friendly operation, multifunctionality, and real-time monitoring, biosensors have brought about remarkable advances for early diagnosis, smart medicine, and healthcare monitoring. − In particular, optical biosensors are famous for high sensitivity, being contact-free, high spatial resolution, etc., and they have shown extensive research emphasis, leading to a large variety of important applications, such as point-of-care diagnostics, mid-infrared molecular fingerprints detection, and field-deployable sensors. − During the past few decades, the optical biosensors based on refractive index (RI) sensing have been cultivated as an important species with a promising future. − Such sensors are usually built by a photonic material that can sustain resonant modes under light excitation, i.e., providing peaks or valleys in absorption, reflection, or transmission spectra. Since the analytes can cause a certain variant of environment RI surrounding the sensing material, the biosensor can detect the existence and amount of analytes by monitoring the spectral shifting induced by the environment RI change.…”