Abstract. In this paper, our approach is to provide a cryptosystem that can be compared to a One-Time Pad. A new cryptosystem approach based on Lorenz chaotic systems is presented for secure data transmission. The system uses a stream cipher, in which the encryption key varies continuously. Furthermore one or more of the parameters of the Lorenz generator is controlled by an auxiliary chaotic generator for increased security. The CDMA system for four users has been tested using MATLAB-SIMULINK. The system has achieved a good performance in presence of noise compared to other communication systems.