Wire Electrodes Embedded in Artificial Conduit for Long-term Monitoring of the Peripheral Nerve Signal

Jung, Woohyun; Jung, Soyoung; Kim, Ockchul; Park, Hyung Dal; Choi, Wonsuk; Son, Donghee; Chung, Seok; Kim, Jinseok

doi:10.3390/mi10030184

Cited by 5 publications

(4 citation statements)

References 28 publications

(31 reference statements)

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“…Efforts should be made to reduce inflammatory reactions around the nerve by periodically injecting or administering anti-inflammatory agents. Wire electrodes are placed inside an artificial conduit, and neural regeneration inductive materials are mounted to induce only nerve fibers to regenerate into the tunnel and inflammatory reactions to form outside the conduit [37]. Further research into the application of these concepts to the development of miniaturized PNIs is required.…”

Section: Discussionmentioning

confidence: 99%

Fork-shaped neural interface with multichannel high spatial selectivity in the peripheral nerve of a rat

Choi,

Park,

et al. 2024

J. Neural Eng.

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Objective. This study aims to develop and validate a sophisticated fork-shaped neural interface (FNI) designed for peripheral nerves, focusing on achieving high spatial resolution, functional selectivity, and improved charge storage capacities. The objective is to create a neurointerface capable of precise neuroanatomical analysis, neural signal recording, and stimulation. Approach. Our approach involves the design and implementation of the FNI, which integrates 32 multichannel working electrodes featuring enhanced charge storage capacities and low impedance. An insertion guide holder is incorporated to refine neuronal selectivity. The study employs meticulous electrode placement, bipolar electrical stimulation, and comprehensive analysis of induced neural responses to verify the FNI's capabilities. Stability over an eight-week period is a crucial aspect, ensuring the reliability and durability of the neural interface. Main Results. The FNI demonstrated remarkable efficacy in neuroanatomical analysis, exhibiting accurate positioning of motor nerves and successfully inducing various movements. Stable impedance values were maintained over the eight-week period, affirming the durability of the FNI. Additionally, the neural interface proved effective in recording sensory signals from different hind limb areas. The advanced charge storage capacities and low impedance contribute to the FNI's robust performance, establishing its potential for prolonged use. Significance. This research represents a significant advancement in neural interface technology, offering a versatile tool with broad applications in neuroscience and neuroengineering. The FNI's ability to capture both motor and sensory neural activity positions it as a comprehensive solution for neuroanatomical studies. Moreover, the precise neuromodulation potential of the FNI holds promise for applications in advanced bionic prosthetic control and therapeutic interventions. The study's findings contribute to the evolving field of neuroengineering, paving the way for enhanced understanding and manipulation of peripheral neural functions.

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Section: Discussionmentioning

confidence: 99%

Fork-shaped neural interface with multichannel high spatial selectivity in the peripheral nerve of a rat

Choi,

Park,

et al. 2024

J. Neural Eng.

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“…Implantation and neural signal measurement of fabricated neural electrodes with the artificial conduit for peripheral nerve tissue regeneration. Source: ref .…”

Section: Introductionmentioning

confidence: 99%

Application of Conductive Hydrogels on Spinal Cord Injury Repair: A Review

Shahemi

Mahat

Asri

et al. 2023

ACS Biomater. Sci. Eng.

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Spinal cord injury (SCI) causes severe motor or sensory damage that leads to long-term disabilities due to disruption of electrical conduction in neuronal pathways. Despite current clinical therapies being used to limit the propagation of cell or tissue damage, the need for neuroregenerative therapies remains. Conductive hydrogels have been considered a promising neuroregenerative therapy due to their ability to provide a pro-regenerative microenvironment and flexible structure, which conforms to a complex SCI lesion. Furthermore, their conductivity can be utilized for noninvasive electrical signaling in dictating neuronal cell behavior. However, the ability of hydrogels to guide directional axon growth to reach the distal end for complete nerve reconnection remains a critical challenge. In this Review, we highlight recent advances in conductive hydrogels, including the incorporation of conductive materials, fabrication techniques, and cross-linking interactions. We also discuss important characteristics for designing conductive hydrogels for directional growth and regenerative therapy. We propose insights into electrical conductivity properties in a hydrogel that could be implemented as guidance for directional cell growth for SCI applications. Specifically, we highlight the practical implications of recent findings in the field, including the potential for conductive hydrogels to be used in clinical applications. We conclude that conductive hydrogels are a promising neuroregenerative therapy for SCI and that further research is needed to optimize their design and application.

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“…They include biosensors, bioconductors, electrostimulated drug delivery systems, and tissue engineering for the diagnosis and treatment of chronic diseases [ 1 ]. IEs can transmit and receive bioelectronic signals from the brain, heart, or muscle, for monitoring and curing chronic diseases [ 2 , 3 , 4 , 5 ]. However, it is challenging to overcome the drawbacks of the hard and rigid characteristics of conventional IEs [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Self-Healing, Stretchable, Biocompatible, and Conductive Alginate Hydrogels through Dynamic Covalent Bonds for Implantable Electronics

et al. 2021

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Implantable electronics have recently been attracting attention because of the promising advances in personalized healthcare. They can be used to diagnose and treat chronic diseases by monitoring and applying bioelectrical signals to various organs. However, there are challenges regarding the rigidity and hardness of typical electronic devices that can trigger inflammatory reactions in tissues. In an effort to improve the physicochemical properties of conventional implantable electronics, soft hydrogel-based platforms have emerged as components of implantable electronics. It is important that they meet functional criteria, such as stretchability, biocompatibility, and self-healing. Herein, plant-inspired conductive alginate hydrogels composed of “boronic acid modified alginate” and “oligomerized epigallocatechin gallate,” which are extracted from plant compounds, are proposed. The conductive hydrogels show great stretchability up to 500% and self-healing properties because of the boronic acid-cis-diol dynamic covalent bonds. In addition, as a simple strategy to increase the electrical conductivity of the hydrogels, ionically crosslinked shells with cations (e.g., sodium) were generated on the hydrogel under physiological salt conditions. This decreased the resistance of the conductive hydrogel down to 900 ohm without trading off the original properties of stretchability and self-healing. The hydrogels were used for “electrophysiological bridging” to transfer electromyographic signals in an ex vivo muscle defect model, showing a great bridging effect comparable to that of a muscle-to-muscle contact model. The use of plant-inspired ionically conductive hydrogels is a promising strategy for designing implantable and self-healable bioelectronics.

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Wire Electrodes Embedded in Artificial Conduit for Long-term Monitoring of the Peripheral Nerve Signal

Cited by 5 publications

References 28 publications

Fork-shaped neural interface with multichannel high spatial selectivity in the peripheral nerve of a rat

Fork-shaped neural interface with multichannel high spatial selectivity in the peripheral nerve of a rat

Application of Conductive Hydrogels on Spinal Cord Injury Repair: A Review

Self-Healing, Stretchable, Biocompatible, and Conductive Alginate Hydrogels through Dynamic Covalent Bonds for Implantable Electronics

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