WIP1 is a novel specific target for growth hormone action

Apaydin, Tugce; Zonis, Svetlana; Zhou, Cuiqi; Valencia, Christian Wong; Barrett, Robert; Strous, Ger J.; Mol, Jan A.; Chesnokova, Vera; Melmed, Shlomo

doi:10.1016/j.isci.2023.108117

Search citation statements

Order By: Relevance

Paper Sections

Select...

Evidence Of Cellular Senescence and Their Impact In Paediatr...1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 78 , 79 , 80 , 81 More recently, a mechanism underlying this activity was unveiled in a study showing that GH signalling leads to WIP1-mediated suppression of the DDR pathway. 82 In the future, it would be interesting to explore the effect of either eliminating these GH-secreting senescent cells, and their SASP, or describing the effect of inhibiting their senescent program, both in somatotropinomas and other organs. Such studies would certainly provide important insights regarding the application of senotherapeutics in somatotropinoma management.…”

Section: Evidence Of Cellular Senescence and Their Impact In Paediatr...mentioning

confidence: 99%