Winner of the young physician’s section of the Gowers’ prize 2000 Too good to be true? Thomas Willis—neonatal convulsions, childhood stroke and infanticide in seventeenth century England

Abstract

A case of neonatal convulsion reported by Thomas Willis (1621-1675) together with its post mortem findings is quoted as being congenital intracerebral haemorrhage or strongly suggested as being the earliest pathological description of childhood cerebrovascular disease. However these authors only reviewed the incomplete written record left by Willis, describing how this case was the fourth consecutive child that the mother had lost to neonatal convulsions. The medical record is completed by notes taken by John Locke from a lecture delivered by Willis 3 or 4 years before the case was first published. Here, Locke relates how the mother subsequently had three further children who were all treated by Willis soon after birth and all survived uneventfully. Reviewing the post mortem findings and the full case histories modern medical science gives a different interpretation. Instead, I suggest that the case history given and pathological features described are more in keeping with a whiplash shaking injury than with cerebrovascular disease or a stroke. I believe that this is the earliest pathological description of shaking injury in childhood. We can never know why Willis did not publish the full success of his management of the subsequent children but it may have been due to his dramatic experience of a similar mother early on in his medical career.

Pediatric stroke: a review

“…children as it is more common in males as compared to females. 5 This male predominance was recently studied in china and 70% of stroke was found to be present in males. 6 But interestingly another study done in England, sex was not associated with increased risk of stroke but age and race are associated with increased incidence as it is more common in younger age and more in Asian and blacks than white.…”