Wingless‐type inducible signaling pathway protein‐1 (WISP1) adipokine and glucose homeostasis

Yaribeygi, Habib; Atkin, Stephen L.; Sahebkar, Amirhossein

doi:10.1002/jcp.28412

Cited by 11 publications

(8 citation statements)

References 39 publications

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“…On the other hand, a study published by Tacke et al (2018) showed no differences in WISP1 levels among individuals with normal glucose tolerance, impaired glucose tolerance, and T2DM. However, a recent report suggested that WISP1 is strongly linked to the progression of insulin resistance, in particular higher circulating levels of WISP1 were found in patients suffering from obesity together with increased insulin resistance (Yaribeygi et al, 2019). Overall, WISP1 seems to play a critical role in many molecular pathways and cellular events; however, further studies are necessary to further deepen its involvement in obesity and metabolic disfunction.…”

Section: Wisp1 Obesity and Metabolic Dysfunctionmentioning

confidence: 98%

Adipokines: New Potential Therapeutic Target for Obesity and Metabolic, Rheumatic, and Cardiovascular Diseases

et al. 2020

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Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic and complex endocrine organ, which produces and secretes several adipokines, including hormones, cytokines, extracellular matrix (ECM) proteins, and growth and vasoactive factors. A wide body of evidence showed that adipokines play a critical role in various biological and physiological functions, among which feeding modulation, inflammatory and immune function, glucose and lipid metabolism, and blood pressure control. The aim of this review is to summarize the effects of several adipokines, including leptin, diponectin, resistin, chemerin, lipocalin-2 (LCN2), vaspin, omentin, follistatin-like 1 (FSTL1), secreted protein acidic and rich in cysteine (SPARC), secreted frizzled-related protein 5 (SFRP5), C1q/TNF-related proteins (CTRPs), family with sequence similarity to 19 member A5 (FAM19A5), wingless-type inducible signaling pathway protein-1 (WISP1), progranulin (PGRN), nesfatin-1 (nesfatin), visfatin/PBEF/NAMPT, apelin, retinol binding protein 4 (RPB4), and plasminogen activator inhibitor-1 (PAI-1) in the regulation of insulin resistance and vascular function, as well as many aspects of inflammation and immunity and their potential role in managing obesity-associated diseases, including metabolic, osteoarticular, and cardiovascular diseases.

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Section: Wisp1 Obesity and Metabolic Dysfunctionmentioning

confidence: 98%

Adipokines: New Potential Therapeutic Target for Obesity and Metabolic, Rheumatic, and Cardiovascular Diseases

et al. 2020

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“…Wingless‐type (Wnt)-inducible signaling pathway protein-1 (WISP1, also known as CCN4) belongs to the Cyr61/CTGF/NOV (CCN) family of matricellular proteins and plays a role in cell adhesion, migration, differentiation, proliferation, and development ( 68 ). Widely expressed by a variety of tissues—including osteoblasts, cardiomyocytes, hepatocytes, neuronal cells, colon, lungs, and myocytes — WISP1 was recently validated as a novel adipokine released from human adipocytes and linked to inflammation and insulin resistance in obesity ( 69 , 70 ).…”

Section: Adipokinesmentioning

confidence: 99%

Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation

et al. 2022

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Chronic low-grade inflammation in adipose tissue (AT) is a hallmark of obesity and contributes to various metabolic disorders, such as type 2 diabetes and cardiovascular diseases. Inflammation in ATs is characterized by macrophage infiltration and the activation of inflammatory pathways mediated by NF-κB, JNK, and NLRP3 inflammasomes. Adipokines, hepatokines and myokines — proteins secreted from AT, the liver and skeletal muscle play regulatory roles in AT inflammation via endocrine, paracrine, and autocrine pathways. For example, obesity is associated with elevated levels of pro-inflammatory adipokines (e.g., leptin, resistin, chemerin, progranulin, RBP4, WISP1, FABP4, PAI-1, Follistatin-like1, MCP-1, SPARC, SPARCL1, and SAA) and reduced levels of anti-inflammatory adipokines such as adiponectin, omentin, ZAG, SFRP5, CTRP3, vaspin, and IL-10. Moreover, some hepatokines (Fetuin A, DPP4, FGF21, GDF15, and MANF) and myokines (irisin, IL-6, and DEL-1) also play pro- or anti-inflammatory roles in AT inflammation. This review aims to provide an updated understanding of these organokines and their role in AT inflammation and related metabolic abnormalities. It serves to highlight the molecular mechanisms underlying the effects of these organokines and their clinical significance. Insights into the roles and mechanisms of these organokines could provide novel and potential therapeutic targets for obesity-induced inflammation.

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“…Adiponectin and adipocyte-fatty acid binding protein (A-FABP) belong to abundantly expressed adipokines par-ticularly related to insulin resistance (Furuhashi, 2019;Yanai and Yoshida, 2019). Recently, association between relatively novel adipokine -Wnt1 inducible signaling pathway protein-1 (WISP-1) and insulin resistance has also been studied (Yaribeygi et al, 2019). Adiponectin and A-FABP were selected as well-known adipokines with proven relation to insulin resistance and cardiovascular diseases (Novotny et al, 2014;Xu and Vanhoutte, 2012;Yanai and Yoshida, 2019).…”

Section: Introductionmentioning

confidence: 99%

Circulating levels of selected adipokines in women with gestational diabetes and type 2 diabetes

Karásek¹,

Krystynik²,

Goldmannová³

et al. 2020

JAB

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Backgrounds: Adiponectin, adipocyte-fatty acid binding protein (A-FABP), and Wnt1 inducible signaling pathway protein-1 (WISP-1) are adipokines closely associated with insulin resistance. The aim of the study was to compare their levels in women with gestational diabetes (GDM), type 2 diabetes mellitus (T2DM) and healthy controls and determine their relation to metabolic parameters. Methods: Women with GDM, T2DM and healthy women were included in this cross-sectional study. In addition to adipokines, anthropometric, lipid parameters, markers of insulin resistance and glucose control were assessed in all participants. Results: Compared to healthy controls (n = 35) significantly lower levels of adiponectin were detected in women with GDM (n = 50), whereas in women with T2DM (n = 50) higher levels of A-FABP and WISP-1 and lower levels of adiponectin were found. Women with T2DM had also lower levels of adiponectin and higher levels of A-FABP compared to women with GDM. A-FABP and adiponectin were independently associated with levels of triglycerides, HDL-cholesterol and C-peptide insulin resistance index. WISP-1 correlated only with waist circumference. Conclusions: Adverse adipokines production reflecting dysfunctional fat tissue is less presented in women with GDM than in women with T2DM, but more expressed compared to healthy women.

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Wingless‐type inducible signaling pathway protein‐1 (WISP1) adipokine and glucose homeostasis

Cited by 11 publications

References 39 publications

Adipokines: New Potential Therapeutic Target for Obesity and Metabolic, Rheumatic, and Cardiovascular Diseases

Adipokines: New Potential Therapeutic Target for Obesity and Metabolic, Rheumatic, and Cardiovascular Diseases

Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation

Circulating levels of selected adipokines in women with gestational diabetes and type 2 diabetes

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