Wine pomace product modulates oxidative stress and microbiota in obesity high-fat diet-fed rats

Gerardi, Gisela; Cavia-Sáiz, Mónica; Rivero-Pérez, María D.

doi:10.1016/j.jff.2020.103903

Cited by 18 publications

(11 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…and Bacteroidetes spp. [ 44 ] Other work with blueberry has found similar results, showing gut microbiota modulation, improvement of barrier integrity (increased villosities and mucin and β-defensin-2 expression), attenuating obesity-associated inflammation (lower proinflammatory cytokines expression), and better response to insulin in rats with diet-induced obesity. [ 45 ]…”

Section: Discussionmentioning

confidence: 81%

Can polyphenols improve the gut health status in pre-clinical study with diet-induced obesity?

et al. 2021

View full text Add to dashboard Cite

Introduction: Obesity is characterized as a low-grade inflammation that impairs physiological functions, including intestinal functioning and gut microbiota balance. Dietary polyphenols can be a strategy for obesity management, collaborating to preserve or recover gut health through antioxidant and anti-inflammatory actions, as well as modulators of the microbiota. This study describes a systematic review protocol to elucidate effects of polyphenols on intestinal health of pre-clinical models with diet-induced obesity. AIM: Our aim is to evaluate evidence about polyphenols’ effects in the gut microbiota composition and diversity, parameters of the physical and molecular status of the gut barrier in obese models, additionally, understand the possible involved mechanisms. Methodology: A protocol was developed and published on PROSPERO (Registration No: CRD42021262445). Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols is used to outline the protocol. The articles will be selected according to the PICOS strategy (population, interventions, control, outcome, and study design) in the following databases: PubMed, Science Direct, Scopus, Web of Science, and EMBASE. Experimental studies performed on rats and mice with a control group that describes treatment with polyphenols (from food matrix or crude extracts or isolated compounds) at any frequency, time, and dose will be included. Two reviewers will, independently, select the papers, extract data, and evaluate the data quality. The Systematic Review Center for Laboratory Animal Experimentation (SYRCLE) tool will be used to assess the risk of bias. Expected results: Results will be showed through of native synthesis and, if possible, a metanalysis will be conducted. The review produced with this protocol can show the scientific evidence level about polyphenols’ effects in intestinal health in obesity status.

show abstract

Section: Discussionmentioning

confidence: 81%

Can polyphenols improve the gut health status in pre-clinical study with diet-induced obesity?

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In previous studies ( Gerardi et al., 2019 ; Del Pino-García et al., 2017 ; Gerardi et al., 2020a ; b ), we have demonstrated the cytoprotective role of polyphenols found in wine pomace products against pro-oxidant and pro-inflammatory agents.…”

Section: Introductionmentioning

confidence: 67%

“…Heat treatment was used to obtain a stable and safe rWPP (red Wine Pomace Product) and wWPP (white Wine Pomace Product). The main characteristics and composition (dietary fiber, fat, protein, minerals, antioxidant capacity and phenolic composition) were determined previously ( Gerardi et al., 2020b ).…”

Section: Methodsmentioning

confidence: 99%

Bioavailable wine pomace attenuates oxalate-induced type II epithelial mesenchymal transition and preserve the differentiated phenotype of renal MDCK cells

Gerardi

Casali

Cavia-Sáiz

et al. 2020

Heliyon

Self Cite

View full text Add to dashboard Cite

The functional renal epithelium is composed of differentiated and polarized tubular cells with a strong actin cortex and specialized cell-cell junctions. If, under pathological conditions, these cells have to resist higher kidney osmolarity, they need to activate diverse mechanisms to survive external nephrotoxic agents such as inflammation and oxidative stress. Wine pomace polyphenols exert protective effects on renal cells. In this study, two winepomace products and their protective effects upon promotion and preservation of normal cell differentiation and attenuation of oxalate-induced type II epithelial mesenchymal transition (EMT) are evaluated. Treatment with gastrointestinal and colonic bioavailable fractions from red (rWPP) and white (wWPP) wine pomaces, both in the presence and the absence of oxalate, showed similar cell numbers and nuclear size than the non-treated differentiated MDCK cells. Immunofluorescence analysis showed the reduction of morphological changes and the preservation of cellular junctions for the rWPP and wWPP pre-treatment of cells exposed to oxalate injury. Hence, both rWPP and wWPP attenuated oxalate type II EMT in MDCK cells that conserved their epithelial morphology and cellular junctions through the antioxidant activities of grape pomace polyphenols.

show abstract

“…Phenolic compounds, especially found in red wines, have proven to have positive effects on human health. Among the most intensively studied of these effects, we could list their protective effects on the cardiovascular system (Haseeb et al ., 2017; Castaldo et al ., 2019), metabolic health (Fragopoulou et al ., 2018; Gerardi et al ., 2020), skin health (Wurz, 2019), and the intestinal–digestive system (Le Roy et al ., 2020), their protective effect against cancer (Dybkowska et al ., 2018; Sharma et al ., 2018), microbial infections (Sánchez et al ., 2019; Abedini et al ., 2021), neurological diseases (Granzotto & Zatta, 2014; Lange, 2018), diabetes (Bahadoran et al ., 2013), and obesity (Castro‐Barquero et al ., 2018) and their effect on improving cognitive performance (Kennedy et al ., 2010).…”

Section: Introductionmentioning

confidence: 99%

Does u.v. light affect the total phenolic compound, anthocyanin, antioxidant capacity, and sensory profiles in wines?

Tahmaz

Küskü

2022

Int J of Food Sci Tech

View full text Add to dashboard Cite

Summary In the study, by applying ultraviolet (u.v.) lights (254 nm) for 45 min to red wines from fermented Cabernet Franc, Cabernet Sauvignon, Merlot, and Petit Verdot (Vitis vinifera L.) grapes, we examined the total phenolic compound, total anthocyanin, and antioxidant capacity by four different methods, trans‐resveratrol, (+)‐catechin, gallic acid content, and the change in tasting profiles of the wines after application. According to the results of the research, the u.v.‐C application has caused an increase in all parameters examined. If we talk about averages without distinguishing between varieties, after the application the total phenolic compound content of 3206 increased to 3356 mg gallic acid equivalent (GAE) per L and after u.v.‐C application, the total anthocyanin content increased from 411 to 780 mg L−1, the ABTS [2,2′‐azinobis(3‐ethyl‐benzothiazoline‐6‐sulphonic acid)] value increased from 30 to 33 μmol trolox mL−1, the DPPH ((2,2‐diphenyl‐1‐picrylhydrazyl) level increased from 13 to 16 μmol trolox mL−1, the FRAP (ferric reducing antioxidant power) level increased from 15 to 16 μmol trolox mL−1, and the CUPRAC (cupric reducing antioxidant capacity) level increased from 40 to 45 μmol trolox mL−1. The u.v. application affected trans‐resveratrol the most among the phenolic compounds and an average increase of 12.99% was obtained. The rate of increase after u.v. application was 3.33% in (+)‐catechin and 5.57% in gallic acid. The highest correlation between antioxidant activity measurement methods was measured to be 0.998 between FRAP and DPPH. In addition, u.v.‐C application has had a positive effect on taste‐based sensory profiles. In recent years, the search for a diet with a high antioxidant content has become even more important.

show abstract

Wine pomace product modulates oxidative stress and microbiota in obesity high-fat diet-fed rats

Cited by 18 publications

References 46 publications

Can polyphenols improve the gut health status in pre-clinical study with diet-induced obesity?

Can polyphenols improve the gut health status in pre-clinical study with diet-induced obesity?

Bioavailable wine pomace attenuates oxalate-induced type II epithelial mesenchymal transition and preserve the differentiated phenotype of renal MDCK cells

Does u.v. light affect the total phenolic compound, anthocyanin, antioxidant capacity, and sensory profiles in wines?

Contact Info

Product

Resources

About