Wine and beer within a moderate alcohol intake is associated with higher levels of HDL-c and adiponectin

Abstract

The scientific evidence available on the association between moderate alcohol intake and levels of blood cardiometabolic markers are still inconsistent and difficult to interpret for future disease prevention. However, we hypothesize that moderate consumption of alcohol is associated with lower levels of inflammation markers and higher levels of protective cardiometabolic markers. Thus, this work aimed to examine the associations of moderate alcohol intake and the type of alcoholic beverage, with metabolic and inflammatory biomarkers. An observational, cross-sectional study including 143 apparently healthy adults 55 years of age and older was performed.Interviewer-administered questionnaires were used to collect information on alcoholic beverage intake frequency, food frequency, physical activity, socioeconomic status, diseases and medications, and other health related habits. Three groups were established prior to recruitment: 1) abstainers and occasional consumers (ABS, N=54); 2) beer consumers (BEER ≥ 80% of total alcohol intake; N=40), and 3) mixed beverage consumers (MIXED; N=49). Univariate ANOVA models, adjusted for confounding factors and co-variables, were performed. HDL-c and P-selectin were significantly higher in the MIXED group than in the ABS group, and adiponectin was higher in the MIXED group compared to the BEER group. All alcohol consumers also had higher mean platelet volume (MPV) values compared to ABS. In linear regression analyses, HDL-c, P-selectin, and adiponectin were positively associated with wine intake (g/day) (P<0.001, P=0.014 and P=0.017, respectively) and MPV with beer intake (P=0.017). In conclusion, this cross-sectional study showed that moderate alcohol intake is associated with higher levels of HDL-c and adiponectin compared to those in abstainers, which is mainly explained by wine intake. ACCEPTED MANUSCRIPT HighlightsManuscript title: Associations of metabolic and inflammatory biomarkers with wine and beer intake in elderly subjects with a moderate consumption of alcohol. A cross-sectional study.

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“…Moderate alcohol consumption has been shown to increase insulin sensitivity [46], and to contributes to a lower risk of diabetes development in Japanese men [47]. It leads also to lower HDLc levels and adiponectin, which inhibits liver fat accumulation [48]. Regarding cardiovascular disorders, the negative effect of alcohol is dose-dependent and related to the type of ingested alcohol [49,50], and it is thus not surprising to see a negative effect of alcohol in our population.…”

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“…No differences were found between the consumption groups in parameters related to inflammatory markers, such as C-reactive protein (CRP) and cytokines. Further analyses showed that moderate wine, but not beer, consumption drove the association between alcohol intake and plasma high-density lipoprotein cholesterol (HDL-C), adiponectin, and soluble platelet (sP)-selectin levels [33].…”

“…Nova et al [33] Observational, cross-sectional study, 143 participants. Participants were classified as abstainers and occasional consumers; predominantly beer consumers, and mixed beverage consumers (including wine, beer, and liquor).…”

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“…Studying the French Paradox, Renaud and de Longeril [6] showed a correlation between a 40% reduction in the incidence of cardiovascular diseases and a platelet anti-aggregation effect of alcohol. Another recent research has shown that red wine consumption is related to an increase in HDL (high density lipoprotein) cholesterol levels [7]. It has been also shown that with a light to moderate red wine consumption there is an improvement in the cognitive abilities and a decrease in the incidence of dementia [8,9].…”