Windows into Canine Leishmaniasis: From Veterinary Diagnosis to Promising<em> In Vitro </em>Models to Target Parasite-Secreted Lipid Bound Vesicles
Áurea Gabriel,
Gilvando Rodrigues Galvão,
Adan Galué-Parra
et al.
Abstract:Leishmaniases are zoonotic vector-borne diseases caused by a wide variety of Leishmania species with complex transmission cycles involving different reservoirs, potential new hosts and vectors. Similarly, to other eukaryotes, Leishmania release extracellular vesicles (LEVs) to play important initial interactions that are crucial to modulate the subsequent systemic immune response on the establishment of infection in humans and others hosts like dogs. Recent studies in endemic areas of Brazil concluded that can… Show more
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