The integration of structural health monitoring into life-cycle management strategies can help facilitating a reliable operation of wind turbines and reducing the life-cycle costs significantly. This paper presents a life-cycle management (LCM) framework for online monitoring and performance assessment of wind turbines, enabling optimum maintenance and inspection planning at minimum associated life-cycle costs. Incorporating continuously updated monitoring data (i.e. structural, environmental and operational data), the framework allows capturing and understanding the actual wind turbine condition and, hence, reduces uncertainty in structural responses as well as load effects acting on the structure. As will be shown in this paper, the framework integrates a variety of heterogeneous hardware and software components, including sensors and data acquisition units, server systems, Internetenabled user interfaces as well as finite element models for system identification and a multiagent system for self-detecting sensor malfunctions. To validate its capabilities and to Smarsly et al. 2 demonstrate its practicability, the framework is deployed for continuous monitoring and lifecycle management of a 500 kW wind turbine. Remote life-cycle analyses of the monitored wind turbine are conducted and case studies are presented investigating both the structural performance and the operational efficiency of the wind turbine.