Winchester Syndrome: Report of a case from Iran

Abstract

A child with Winchester syndrome, studied in Iran, is the sixth reported case in the literature. The cutaneous manifestations of this syndrome include leathery thickening of the skin, hyperpigmentation and hypertrichosis. The lips and gingiva are hypertrophic. There are also arthritic changes involving the small joints.

Winchester syndrome: a case report

“…Our case had typical skeletal radiologic features, short stature, articular contractures, gum hypertrophy, and thickened skin, thus satisfying the criteria for the diagnosis of this rare condition. Osteolysis has not been reported in those aged less than 1 year and was conspicuously absent in our case for this reason 6 . Corneal opacities are generally found after the age of 2–5 years, but were not reported in one 16‐year‐old girl 2,7 .…”

“…Osteolysis has not been reported in those aged less than 1 year and was conspicuously absent in our case for this reason. 6 Corneal opacities are generally found after the age of 2-5 years, but were not reported in one 16-year-old girl. 2,7 The absence of corneal abnormalities in our case is thus not unusual.…”

Winchester syndrome

“…Basic laboratory tests are usually within normal limits. In three patients [3,6] IgM was slightly raised. The excretion of urinary oligosaccharide was increased in two patients [2].…”

“…Since then nine other cases of WS have been reported in the west [2,3,4,5,6,7,8,9]. Onset of the disease is usually within the first year of life.…”

Human Protothecosis

“…Cases have been reported from Europe (61,77,78,93,129), Asia (28,85,86,96,145,147,169), Africa (36), Oceania (55), and South and North America (45,90,166,167), particularly the southeast United States (45,55,158,166). In Taiwan, the rural region is most affected, displaying a high population of farmers and elderly people (27).…”