Wilson's disease with and without rapid eye movement sleep behavior disorder compared to healthy matched controls

Tribl, Gotthard G.; Trindade, Mateus C.; Bittencourt, Thais; Lorenzi-Filho, Geraldo; Alves, Rosana Cardoso; Andrade, Daniel Ciampi de; Fonoff, Erich Talamoni; Bor‐Seng‐Shu, Edson; Machado, A. A.; Schenck, Carlos H.; Teixeira, Manoel Jacobsen; Barbosa, Egberto Reis

doi:10.1016/j.sleep.2015.09.003

Cited by 30 publications

(11 citation statements)

References 48 publications

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“…It is possible that the true frequency of RBD in WD might even be higher than in our cohort, as patients with cognitive deficits may not be aware of RBD symptoms. This possibility gains support by the finding of nine WD patients (4 males, 5 females) in our cohort, who did not fulfill clinical criteria of RBD, but showed increased RWA (two SD above the mean of healthy controls) [ 15 ]. To what extent dreaming, on the background of increased RWA, is necessary to trigger off motor behaviour during REM sleep is an open question in the pathophysiology of RBD.…”

Section: Discussionsupporting

confidence: 53%

“…In a prior publication, we have reported on sleep characteristics of a cohort of 41 patients with WD, including five patients with WD and RBD [ 15 ]. Diagnostic procedures and the video-polysomnography documented sleep disorder have been published before [ 15 ]. The present study reports on the dream characteristics of this cohort.…”

Section: Methodsmentioning

confidence: 99%

“…In addition, RBD has been recently described also in WD [ 14 ]. Polysomnography parameters and sleep quality have been shown to be significantly worse in WD, both with and without RBD, as compared to healthy controls [ 15 ]. Diseases, which structurally affect the brain like stroke, traumatic brain injury, neoplasm, Parkinson's disease, Alzheimer's disease, fatal familial insomnia, and sporadic Creutzfeldt-Jakob disease, have been shown to have impact on dreaming [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Dream Recall Frequencies and Dream Content in Wilson’s Disease with and without REM Sleep Behaviour Disorder: A Neurooneirologic Study

Tribl

Trindade

Schredl

et al. 2016

Behavioural Neurology

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Objective. Violent dream content and its acting out during rapid eye movement sleep are considered distinctive for rapid eye movement sleep behaviour disorder (RBD). This study reports first quantitative data on dreaming in a cohort of patients with treated Wilson's disease (WD) and in patients with WD with RBD. Methods. Retrospective questionnaires on different dimensions of dreaming and a prospective two-week home dream diary with self-rating of emotions and blinded, categorical rating of content by an external judge. Results. WD patients showed a significantly lower dream word count and very few other differences in dream characteristics compared to age- and sex-matched healthy controls. Compared to WD patients without RBD, patients with WD and RBD reported significantly higher nightmare frequencies and more dreams with violent or aggressive content retrospectively; their prospectively collected dream reports contained significantly more negative emotions and aggression. Conclusions. The reduction in dream length might reflect specific cognitive deficits in WD. The lack of differences regarding dream content might be explained by the established successful WD treatment. RBD in WD had a strong impact on dreaming. In accordance with the current definition of RBD, violent, aggressive dream content seems to be a characteristic of RBD also in WD.

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Section: Discussionsupporting

confidence: 53%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dream Recall Frequencies and Dream Content in Wilson’s Disease with and without REM Sleep Behaviour Disorder: A Neurooneirologic Study

Tribl

Trindade

Schredl

et al. 2016

Behavioural Neurology

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“…Diagnosis of WD and video‐polysomnography (VPSG) were performed as described before . On a clinical background of WD, the diagnosis was established by low serum ceruloplasmin (<20 mg/dl), elevated pretreatment 24‐h urine excretion (>100 μg/24 h), and the presence of Kayser–Fleischer rings on slit lamp examination.…”

Section: Methodsmentioning

confidence: 99%

Restless legs syndrome in Wilson's disease: frequency, characteristics, and mimics

et al. 2016

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“…Amyloid precursor protein (APP), which is implicated in AD, is a copper binding protein (Nevsimalova et al, 2011). Patients with Wilson’s disease have been reported to have sleep disturbances including RBD, restless leg syndrome, daytime hypersomnolence, excessive nighttime wakefulness, and circadian disruption (Firneisz et al, 2000, Nevsimalova et al, 2011, Amann et al, 2015, Tribl et al, 2016). …”

Section: Introductionmentioning

confidence: 99%

Metals and Circadian Rhythms

Parmalee

Aschner

2017

Advances in Neurotoxicology

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Circadian rhythms describe the behavioral and physiological changes that occur in living organisms in order to attune to a 24 hour cycle of day and night. The most striking aspect of circadian function is the sleep-wake cycle, however many other physiological processes are regulated in 24 hour oscillations, including blood pressure, body temperature, appetite, urine production, and the transcription and translation of thousands of circadian dependent genes. Circadian disruption and sleep disorders are strongly connected to neurodegenerative diseases including Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease as well as others. Metal exposures have been implicated in neurodegenerative diseases, in some cases involving metals that are essential micronutrients but are toxic at high levels of exposure (such as manganese, copper, and zinc), and in other cases involving metals that have no biological role but are toxic to living systems (such as lead, mercury, and aluminum). In this review, we examine the evidence for circadian and sleep disorders with exposures to these metals and review the literature for possible mechanisms. We suggest that giving the aging population, the prevalence of environmental exposures to metals, and the increasing prevalence of neurodegenerative disease in the aged, more research into the mechanisms of circadian disruption subsequent to metal exposures is warranted.

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Wilson's disease with and without rapid eye movement sleep behavior disorder compared to healthy matched controls

Cited by 30 publications

References 48 publications

Dream Recall Frequencies and Dream Content in Wilson’s Disease with and without REM Sleep Behaviour Disorder: A Neurooneirologic Study

Dream Recall Frequencies and Dream Content in Wilson’s Disease with and without REM Sleep Behaviour Disorder: A Neurooneirologic Study

Restless legs syndrome in Wilson's disease: frequency, characteristics, and mimics

Metals and Circadian Rhythms

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