Wilson-Mikity respiratory distress syndrome.

Wilson-Mikity Syndrome – A Rare Interstitial Pulmonary Disease in Neonates

“…Table 1. Clinical anamnestic description of WMS patients and outcomes [1,3,9,12,14,15,[20][21][22][23][24][25]…”

“…Moreover, specific radiographic alterations were detected in chest X-ray films of all the patients [1]. Since publication of the first WMS description, isolated cases of the disease were registered in Denver [2], Baltimore and Boston [3], New York [4], Switzerland [5], Canada [6], Australia [7], Italy [8], Nigeria [9], England [10] and other cities and countries. Apparently, the disease is geographically widespread.…”

“…Bronchoscopy and bronchography of the WMS patients revealed normal bronchial tree structure. Biopsy tissue culture tests for viruses were in most cases negative [1][2][3][4][5][6][7][8][9][10]. However, J. Butterfield et al revealed type 19 echovirus (ECHO) in one case [2]; C.H.…”

“…However, J. Butterfield et al revealed type 19 echovirus (ECHO) in one case [2]; C.H. Sinnette et al revealed type 7 ECHO virus in nasopharynx of one child with WMS [9]. P. Reittner et al published a case study of a child with WMS; histologic examination of the child's lung tissue detected cytomegalovirus particles in endothelial cells of venules and capillaries, in type II pneumocytes and alveolar macrophages [13].…”

“…The disease takes the severest course in the least mature infants. The disease usually manifests itself in the 5 th -35 th postnatal day; the available data also state that WMS may manifest itself as early as in the first postnatal day or as late as in the 15 th postnatal week [1,3,9,12,14,15,[20][21][22][23][24][25]. In several studies children with WMS developed neonatal respiratory distress syndrome (RDS) in the first postnatal days, which would require oxygen therapy and be terminated in the 3 rd -4 th postnatal day [12,14].…”