Wilms’ tumour: A review of 15 years recent experience

Illade, Laura; Hernández-Marqués, Carmen; Cormenzana, M.; Lassaletta, Álvaro; Catalán, Maitane Andión; Ruano, David; Fioravantti, Victoria; López, L. Madero

doi:10.1016/j.anpede.2017.03.019

Cited by 6 publications

(4 citation statements)

References 21 publications

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“…The most common symptoms that presented were nonspecific symptoms, abdominal distension, and discomfort, according to a research by Naveed et al; [40] similar findings were reported by another study. Naveed also reported that about 1/3 of the patients had hypertension, Maas et al found up to 55% of their patients suffering from HTN too, this is thought to be due to the high level of renin.…”

Section: Tumors (Cancers) Of the Central Nervous System And Other Int...supporting

confidence: 83%

Epidemiological Trends in Childhood Cancer in Saudi Arabia

Hamid¹,

Albalawi²,

Aloufi³

et al. 2022

Clin Cancer Investig J

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The incidence of new childhood cancer cases is 15.3 per 100,000 per year, or nearly 1 in 6,500 children and adolescents under the age of 20, notwithstanding the rarity of the disease. The largest nation in the Gulf is the Kingdom of Saudi Arabia.The provision of the best healthcare is hampered by a young population with longer life expectancies, a recognised rising cancer burden both locally and globally.Similar to other developing nations, the incidence of cancer has increased over time in KSA, which may be attributable to advancements in medical technology, diagnostic methods, and an efficient system for referring patients for additional testing and treatment to well-known tertiary hospitals and oncology-specific treatment facilities in the major cities.The study seeks to provide an overview of recent developments on the incidence of paediatric cancer in Saudi Arabia. As the most common form of paediatric cancer in KSA, leukaemia requires an immediate diagnosis in order to develop a treatment plan that will have the greatest therapeutic benefit and the fewest adverse effects. There are further cancers with lesser prevalence rates, such as lymphoma, kidney, bone, and brain tumours.

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Section: Tumors (Cancers) Of the Central Nervous System And Other Int...supporting

confidence: 83%

Epidemiological Trends in Childhood Cancer in Saudi Arabia

Hamid¹,

Albalawi²,

Aloufi³

et al. 2022

Clin Cancer Investig J

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“…CT of the abdomen with administration of intravenous iodinated contrast is also used for diagnosis and evaluation of nephroblastomas [ 14 , 17 , 18 ]. We performed CT scans as the main imagistic method for preoperative staging in all patients.…”

Section: ⧉ Discussionmentioning

confidence: 99%

Prediction of histopathological local staging by radiological findings and differential diagnosis overview in children with nephroblastoma

Bălănescu

Bălănescu²,

Strîmbu³

et al. 2022

Rom J Morphol Embryol

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Background : Nephroblastoma is the most common renal malignancy in children kidney. They are highly heterogeneous tumors with challenging imagistic and histopathological (HP) differential diagnosis. Imaging is critical for understanding local anatomy, staging and for planning surgical approach. Purpose : To determine whether HP staging can be successfully predicted by the imagistic staging using computed tomography. Also, we find it important to make a brief review of the imagistic, HP and immunohistochemical differential diagnosis of nephroblastoma, considering that a correct diagnosis is essential for an appropriate therapeutic strategy in all stages. Patients, Materials and Methods : We present a retrospective study of the medical dossiers of 22 patients that underwent surgery at our Center between 2014 and 2020. We provided descriptive data and compared imagistic and HP staging using a Mann–Whitney U -test. An up-to-date literature review was also done. Results : We found that imagistic staging tends to under- or over-stage at similar rates and that the difference between the two staging systems is statistically significant. Immunohistochemistry is necessary for establishing the correct diagnosis, especially in cases with one predominant HP pattern. Conclusions : HP and imagistic staging are not yet sufficiently similar for successfully predict the former via imagistic means.

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“…The overall survival for children with WT has reached 90% and 75% for localized and metastatic disease, respectively. However, WT patients with high-risk histology and/or tumor relapses have a survival rate of 50% [ 67 , 68 ].…”

Section: From Neuroblastoma To Wilms’ Tumor: the Impact On Nk Cellsmentioning

confidence: 99%

Pediatric Tumors-Mediated Inhibitory Effect on NK Cells: The Case of Neuroblastoma and Wilms’ Tumors

Pelosi

Fiore

Matteo

et al. 2021

Cancers

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Natural killer (NK) cells play a key role in the control of cancer development, progression and metastatic dissemination. However, tumor cells develop an array of strategies capable of impairing the activation and function of the immune system, including NK cells. In this context, a major event is represented by the establishment of an immunosuppressive tumor microenvironment (TME) composed of stromal cells, myeloid-derived suppressor cells, tumor-associated macrophages, regulatory T cells and cancer cells themselves. The different immunoregulatory cells infiltrating the TME, through the release of several immunosuppressive molecules or by cell-to-cell interactions, cause an impairment of the recruitment of NK cells and other lymphocytes with effector functions. The different mechanisms by which stromal and tumor cells impair NK cell function have been particularly explored in adult solid tumors and, in less depth, investigated and discussed in a pediatric setting. In this review, we will compare pediatric and adult solid malignancies concerning the respective mechanisms of NK cell inhibition, highlighting novel key data in neuroblastoma and Wilms’ tumor, two of the most frequent pediatric extracranial solid tumors. Indeed, both tumors are characterized by the presence of stromal cells acting through the release of immunosuppressive molecules. In addition, specific tumor cell subsets inhibit NK cell cytotoxic function by cell-to-cell contact mechanisms likely controlled by the transcriptional coactivator TAZ. These findings could lead to a more performant diagnostic approach and to the development of novel immunotherapeutic strategies targeting the identified cellular and molecular targets.

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Wilms’ tumour: A review of 15 years recent experience

Cited by 6 publications

References 21 publications

Epidemiological Trends in Childhood Cancer in Saudi Arabia

Epidemiological Trends in Childhood Cancer in Saudi Arabia

Prediction of histopathological local staging by radiological findings and differential diagnosis overview in children with nephroblastoma

Pediatric Tumors-Mediated Inhibitory Effect on NK Cells: The Case of Neuroblastoma and Wilms’ Tumors

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