Wilms tumor with inferior vena cava duplication: a rare case report

Guo, Feng; Li, Tianyou; Liu, Wei; Wang, Gang; Ma, Rui; Wu, Renyi

doi:10.1186/s12894-018-0401-0

Cited by 5 publications

(4 citation statements)

References 24 publications

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“…Since there are no distinguishing histological features between adult and pediatric Wilms' tumors, three diagnostic criteria have been established to identify ERWTs. First, it is essential to rule out a primary intrarenal tumor with secondary extrarenal metastases or a supernumerary kidney (9)(10)(11). Second, the pathologic assessment should reveal Wilms' tumor's characteristic triphasic histologic pattern.…”

Section: Discussionmentioning

confidence: 99%

First Incidence of Extrarenal Wilms Tumor within the Spinal Canal in the Adult Population: A Novel Case Report and Literature Review

Alijani,

Abbaspour,

Karimzadhagh

et al. 2024

Preprint

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Background: Wilms tumor (WT), also known as nephroblastoma, is a rare occurrence in adults, accounting for merely 3% of all nephroblastomas or 0.2 cases per million individuals. Extrarenal Wilms tumor (ERWT) emerges outside the renal confines and comprises 0.5 to 1% of all WT cases. Although ERWT is more prevalent in children, its incidence in adults signifies an even rarer incidence. Oncogenic mutations associated with ectopic nephrogenic rests (NR) may contribute to ERWT development. Diagnosis involves surgical resection and pathology examination. Due to scarce cases, adults often rely on pediatric guidelines. We conducted a thorough search on PubMed, Scopus, and Web of Science databases to establish our case's uniqueness. To the best of our knowledge, this is the first documented incidence of extrarenal Wilms tumor within the spinal canal in the adult population. Case presentation: A 22-year-old woman with a history of congenital lipo-myelomeningocele surgery as an infant presented with a 6-month history of back pain. This pain gradually resulted in limb weakness, paraparesis, and loss of bladder and bowel control. An MRI showed a 6x5x3 cm spinal canal mass at the L4-S1 level. Consequently, a laminectomy was performed at the L4-L5 level to remove the intramedullary tumor. Post-surgery histopathology and immunohistochemistry confirmed the tumor as ERWT with favorable histology without any teratomatous component. Conclusion: This report underscores a rare case of ERWT in an adult, challenging conventional diagnostics. Timely surgical intervention is recommended for similar masses, emphasizing the need for further research and clinical awareness.

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Section: Discussionmentioning

confidence: 99%

First Incidence of Extrarenal Wilms Tumor within the Spinal Canal in the Adult Population: A Novel Case Report and Literature Review

Alijani,

Abbaspour,

Karimzadhagh

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Since there are no distinguishing histological features between adult and pediatric Wilms’ tumors, three diagnostic criteria have been established to identify ERWTs. First, it is essential to rule out a primary intrarenal tumor with secondary extrarenal metastases or a supernumerary kidney [ 9 – 11 ]. Second, the pathologic assessment should reveal Wilms’ tumor’s characteristic triphasic histologic pattern.…”

Section: Discussionmentioning

confidence: 99%

First incidence of extrarenal wilms tumor within the spinal canal in the adult population: a novel case report and literature review

Alijani,

Abbaspour,

Karimzadhagh

et al. 2024

BMC Urol

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Background Wilms tumor (WT), also known as nephroblastoma, is rare in adults, accounting for merely 3% of all nephroblastomas or 0.2 cases per million individuals. Extrarenal Wilms tumor (ERWT) emerges outside the renal boundaries and comprises 0.5 to 1% of all WT cases, with even rarer incidences in adults. Oncogenic mutations associated with ectopic nephrogenic rests (NR) may contribute to ERWT development. Diagnosis involves surgical resection and pathology examination. Due to scarce cases, adults often rely on pediatric guidelines. We thoroughly searched PubMed, Scopus, and Web of Science databases to establish our case’s uniqueness. To the best of our knowledge, this is the first documented incidence of extrarenal Wilms tumor within the spinal canal in the adult population. Case presentation A 22-year-old woman with a history of congenital lipo-myelomeningocele surgery as an infant presented with a 6-month history of back pain. This pain gradually resulted in limb weakness, paraparesis, and loss of bladder and bowel control. An MRI showed a 6 × 5 × 3 cm spinal canal mass at the L4-S1 level. Consequently, a laminectomy was performed at the L4-L5 level to remove the intramedullary tumor. Post-surgery histopathology and immunohistochemistry confirmed the tumor as ERWT with favorable histology without any teratomatous component. Conclusion This report underscores the rarity of extrarenal Wilms tumor (ERWT) in adults, challenging conventional assumptions about its typical age of occurrence. It emphasizes the importance of clinical awareness regarding such uncommon cases. Moreover, the co-occurrence of spinal ERWTs and a history of spinal anomalies warrants further investigation.

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“…The lymphatic system generally follows the vasculature pattern and therefore, lymph node sampling and/or dissection in malignancy may need to be adjusted to account for the unusual patterns of lymph node metastases. Moreover, duplicated IVC and its associated vascular anomalies can often be mistaken as lymphadenopathy, ureteric dilatation, and other intra-abdominal pathology that may potentially lead to unnecessary investigation, over-staging and incorrect decision making [ 11 - 12 ].…”

Section: Discussionmentioning

confidence: 99%

Duplicated Inferior Vena Cava in a Patient With Ampullary Adenocarcinoma: A Case Report and Literature Review of Anatomical Variations

Cheung¹,

Wong²

2020

Cureus

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Duplicated inferior vena cava (IVC) is a rare anatomical anomaly as a result of failed regression of the left supracardinal vein during the embryonic stage. This anatomical variation has certain surgical implications and could lead to potential catastrophe perioperatively. We hereby report a case of a 54 years old male in whom a whipple procedure was performed with type 1 duplicated IVC for ampullary adenocarcinoma. Review of current literature of such anatomical anomaly will also be discussed. This venous anomaly must be kept in mind in all surgical procedures involving the retroperitoneum to minimise the risk of incomplete lymph node dissection and life-threatening bleeding, and to guide management for deep vein thrombosis in the post-operative setting.

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Wilms tumor with inferior vena cava duplication: a rare case report

Cited by 5 publications

References 24 publications

First Incidence of Extrarenal Wilms Tumor within the Spinal Canal in the Adult Population: A Novel Case Report and Literature Review

First Incidence of Extrarenal Wilms Tumor within the Spinal Canal in the Adult Population: A Novel Case Report and Literature Review

First incidence of extrarenal wilms tumor within the spinal canal in the adult population: a novel case report and literature review

Duplicated Inferior Vena Cava in a Patient With Ampullary Adenocarcinoma: A Case Report and Literature Review of Anatomical Variations

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