Wilms’ tumor and exposures to residential and occupational hazardous chemicals

Tsai, James H.; Kaye, Wendy; Bove, Frank

doi:10.1016/j.ijheh.2005.09.003

Cited by 32 publications

(24 citation statements)

References 18 publications

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“…Paternal smoking status and postnatal environmental or chemical hazard exposure experienced, which may also be associated with some childhood tumors, also could not be measured [16,49,57,17,68]. Exposure to household pesticides and increased risk of Wilms tumor have yet to be firmly established [61,69]; however, a review of studies has described that some association exists between pesticides and childhood cancer [63].…”

Section: Discussionmentioning

confidence: 99%

Maternal smoking during pregnancy and childhood cancer in New South Wales: a record linkage investigation

Stavrou

Baker

Bishop

2009

Cancer Causes Control

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Following linkage between the NSW Central Cancer Registry (CCR) and the NSW Midwives Data Collection, an investigation of the association between maternal smoking during pregnancy and the risk of childhood cancer in their offspring was undertaken. Children born in NSW between 1994 and 2005, inclusive of 1,045,966 babies, were matched to 948 cancer cases in the CCR. After adjustment for maternal age, gestational age, baby's gender, birth weight, remoteness index, socioeconomic disadvantage and maternal health factors, no association (OR = 0.96, 95% CI 0.81-1.15, p = 0.68) was found with childhood cancer between mothers who smoked (81/100,000) and those who did not smoke during pregnancy (99/100,000). Maternal smoking was, however, significantly associated with retinoblastoma (OR = 2.20, 95% CI 1.19-4.09, p = 0.01). Association between maternal smoking and preterm birth and low birth weight was significant. Maternal smoking during pregnancy is significantly associated with retinoblastoma and adverse birth outcomes. These results should be highlighted to expectant mothers through antitobacco-smoking campaigns.

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Section: Discussionmentioning

confidence: 99%

Maternal smoking during pregnancy and childhood cancer in New South Wales: a record linkage investigation

Stavrou

Baker

Bishop

2009

Cancer Causes Control

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“…Children spend a lot of time with pets, on the floor, and in the yard—all places where pesticide use can be high (Davis et al 1992; Fenske et al 1990; Garry 2004; Lewis et al 1994; Morgan et al 2005). Studies have investigated associations between parental pesticide exposure in agricultural, occupational, and residential settings and the risk of Wilms tumor, with mixed results (Fear et al 1998; Kristensen et al 1996; Olshan et al 1993; Sharpe et al 1995; Tsai et al 2006; Wilkins and Sinks 1984). One study reported an association between household extermination and Wilms tumor (Olshan et al 1993), whereas another study reported no association between residential pesticides and Wilms tumor (Wilkins and Sinks 1984).…”

mentioning

confidence: 99%

“…One study reported an association between household extermination and Wilms tumor (Olshan et al 1993), whereas another study reported no association between residential pesticides and Wilms tumor (Wilkins and Sinks 1984). The most recent study (Tsai et al 2006) examined pesticide exposure through maternal questionnaire, reporting an odds ratio of 1.3 [90% confidence interval (CI) 0.8–2.0] for maternal pesticide use during pregnancy. To explore further the association between residential pesticide use and the development of Wilms tumor, we conducted a large case–control study that included detailed information on residential pesticide exposure.…”

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confidence: 99%

Household Pesticides and the Risk of Wilms Tumor

Cooney

Daniels

Ross

et al. 2007

Environ Health Perspect

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BackgroundPrevious epidemiologic studies have suggested that exposure to pesticides in utero and during early childhood may increase the risk for development of childhood cancer, including Wilms tumor, a childhood kidney tumor.ObjectivesIn this analysis we evaluated the role of residential pesticide exposure in relation to the risk of Wilms tumor in children using data from a North American case–control study.MethodsThe National Wilms Tumor Study Group (NWTSG) collected information on exposure to residential pesticides from the month before pregnancy through the diagnosis reference date using detailed phone interviews from 523 case mothers and 517 controls frequency matched on child’s age and geographic region and identified by list-assisted random digit dialing. Pesticides were grouped according to type of pesticide and where they were used.ResultsA slightly increased risk of Wilms tumor was found among children of mothers who reported insecticide use [odds ratio (OR) = 1.4, 95% confidence interval (CI), 1.0–1.8; adjusted for education, income, and the matching variables]. Results from all other categories of pesticides were generally close to the null.ConclusionsThis study is the largest case–control study of Wilms tumor to date. We were unable to confirm earlier reports of an increased risk for Wilms tumor among those exposed to residential pesticides during pregnancy through early childhood.

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Section: Discussionmentioning

confidence: 99%

“…45 Wilms tumor was also reported in children with spina bifida. 46,47 These findings are intriguing given the important role that folic acid may play in early placental development, as it reportedly increases low Apgar score is also positively associated with small placenta and low placenta-to-birthweight ratio. 50,51 Similarly, meconium staining, pregnancy hypertension, and fetal hydrops have been independently reported with both Wilms tumor and lower placenta weight.…”

Section: Discussionmentioning

confidence: 99%

Fetal programming and Wilms tumor

Heck

Janzen

et al. 2018

Pediatric Blood & Cancer

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Background: The ‘fetal programming’ hypothesis has been evaluated in many adult diseases including cancer, but not for Wilms tumor. Wilms tumor has been related to high birthweight but little is known about other growth metrics such as a baby’s birth length, ponderal index, or placenta size, which can shed additional light on growth patterns. Methods: Cases of Wilms tumor (N=217) were taken from the Danish Cancer Registry, and controls (N=4,340) were randomly selected from the Population Register and matched to cases by sex and age. Linkage to the Medical Births Registry provided information on gestational factors and fetal growth measurements, while linkage to the Patient Register provided information on maternal and child health conditions. Results: Despite having typically normal to higher birthweights, Wilms tumor cases had smaller placentas (≤540g; Odds Ratio (OR) = 4.24; 95% Confidence Interval (CI) 1.84, 9.78) and a lower placenta to birthweight ratio (OR =1.81; 95% CI 1.17, 2.82, per 1 SD decrease). Small placentas were more common among Wilms cases without congenital anomalies (OR = 6.43; 95% CI 1.95, 21.21). Wilms tumor cases had a higher prevalence of high birth weight (>4000 g; OR = 1.57; 95% CI 1.11, 2.22), birth length 55cm or longer (OR = 1.74; 95% CI 1.09, 2.78), and being large for gestational age (OR = 1.79; 95% CI 1.08, 2.96). Conclusions: Our study corroborates earlier studies showing associations with high birthweight, and suggests associations between Wilms tumor and decreased placental size and low placenta-to-birthweight ratio.

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Wilms’ tumor and exposures to residential and occupational hazardous chemicals

Cited by 32 publications

References 18 publications

Maternal smoking during pregnancy and childhood cancer in New South Wales: a record linkage investigation

Maternal smoking during pregnancy and childhood cancer in New South Wales: a record linkage investigation

Household Pesticides and the Risk of Wilms Tumor

Fetal programming and Wilms tumor

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