Willingness to Pay in Dermatology: Assessment of the Burden of Skin Diseases

Seidler, Anne M.; Bayoumi, Ahmed M.; Goldstein, Mary K.; Cruz, Ponciano D.; Chen, Shuo

doi:10.1038/jid.2012.50

Cited by 31 publications

(47 citation statements)

References 14 publications

(19 reference statements)

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“…Health impact assessments are usually driven by mortality risks because, at least with approaches based on “willingness to pay”, deaths by far outweigh any other costs of disease [49]. Since the reasons for the reduced risk of melanoma deaths at higher altitudes are unknown, unambiguous conclusions could not be drawn.…”

Section: Discussionmentioning

confidence: 99%

Temporal and Spatial Melanoma Trends in Austria: An Ecological Study

Haluza

Simic

Moshammer

2014

IJERPH

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Annual solar ultraviolet radiation (UVR) is mostly determined by latitude and altitude. Over the last decades, increasing UVR ground levels have been observed. Exposure to UVR is associated with a life-time risk to develop melanoma, a malign skin cancer. Thus, we hypothesized that melanoma incidence in Austria is associated with altitude of place of living and time of diagnosis. We investigated this hypothesis in an ecological study by district and year for Austrian melanoma incidence (1990–2010) and mortality (1970–2011) data. As expected, incidence rates increased with altitude (about 2% per 10 m) and year (about 2%). Additionally, melanoma incidence rates were about 50% higher in urban than in rural districts. In contrast, mortality rates decreased with altitude (for males: 0.4% per 10 m, for women: 0.7% per 10 m, respectively). The observed discrepancy between incidence and mortality data could partly be explained by melanoma diagnosis at earlier tumor stage in districts with higher altitude. Possible reasons for this finding include higher awareness of patients, better diagnostic performance of medical professionals working at higher altitudes, or slower tumor growth due to protective effects of sun light-associated vitamin D synthesis.

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Section: Discussionmentioning

confidence: 99%

Temporal and Spatial Melanoma Trends in Austria: An Ecological Study

Haluza

Simic

Moshammer

2014

IJERPH

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“…Traditionally, methods such as the time trade-off (TTO), standard gamble or willingness to pay (WTP) are used to generate a utility weighting. 31 Utility weightings are assigned to different health states ranging from 1, representing perfect health, to 0, representing death. 12 The standard gamble usually involves giving patients a choice to assume a risk of immediate death for immediate cure, employing an algorithm based on the preferences reported to determine a utility weighting.…”

Section: Quality Of Life Utility Weightingsmentioning

confidence: 99%

Quality of life in non‐melanoma skin cancer

2014

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Basal cell carcinoma and squamous cell carcinoma are the most common malignancies and are classified under the umbrella of non-melanoma skin cancer (NMSC). NMSC exerts a small but appreciable decrement in quality of life (QOL). The impact posed may arise from the tumour itself or as a result of treatment, and through symptoms, functional limitations, cosmetic burden and auxiliary considerations such as cost and disturbance to the activities of daily living. Researchers have evaluated this burden using a variety of outcome measures including generic, dermatology-specific and disease-specific instruments. The skin cancer index represents a promising disease-specific patient-reported outcome measure in this setting. To overcome some of the constraints inherent to disease-specific instruments, and to allow comparisons with other diseases, utility weightings have been developed. Utility weightings represent a cardinal measure for a specific health status and are established through methods such as the standard gamble, willingness-to-pay and time trade-off, and have also been employed to generate utility weightings for NMSC. Utilities are becoming increasingly important as a means of comparing health states across medicine and are of particular importance from a health-care policy perspective as they are used for resource allocation. The small but definite impact on the individual's QOL posed by NMSC should be a clinical consideration for physicians and it should be recognised by researchers as a potential outcome measure.

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“…For participants with depression, treatment duration and individual cost were highly important . In addition, patients with longer disease duration set significant higher importance to the duration of benefit and those receiving injectables valued the probability of benefit, treatment location, delivery method, treatment frequency and duration more …”

Section: Resultsmentioning

confidence: 99%

A systematic review on methods used to evaluate patient preferences in psoriasis treatments

Gutknecht

Schaarschmidt

Herrlein

et al. 2016

Acad Dermatol Venereol

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In the treatment of psoriasis and psoriatic arthritis, recently approved medications undergo the 'early benefit assessment' in Germany. Psoriasis treatments differ in a multiplicity of characteristics like side-effects, beneficial effect, cost and process attributes, which serve to evaluate the patient-relevant benefit compared to standard treatments. Patient preferences might help to aggregate the various patient-relevant outcomes into a single measure. In this context, besides the calculation of the quality-adjusted life-years (QALYs), the Institute for Quality and Efficiency in Health Care (IQWiG) refers to methods of multi-criteria decision making or preference evaluation like analytic hierarchy process and conjoint analysis. The objective was to give an overview of methods that have been used in international published studies to evaluate patient preferences in psoriasis treatments. The review is based on a systematic literature research on December 2014 in selected electronic databases, using the keywords 'psoriasis' and 'preferences' as well as the name of specific methods, known from the literature to evaluate patient preferences. The search resulted 389 hits without duplicates. 21 articles met the inclusion criteria. Depending on the study objective, preferences were elicited for health states, health state domains, treatment attributes or treatment alternatives focusing on different outcomes of preferences. Thereby, different methods were used in included studies. For this reason, there is no single outcome available that might be useful in the benefit assessment of the IQWiG. Willingness-to-pay, often included as part of a conjoint analysis, was the predominant method to elicit preferences. So far, the analytic hierarchy process has not been used in psoriasis studies. The use of this method in future studies might provide new essential knowledge in the evaluation of patient preferences in psoriasis treatments. However, a clear assignment when to use which method is not given by the IQWiG and should be prioritized.

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Willingness to Pay in Dermatology: Assessment of the Burden of Skin Diseases

Cited by 31 publications

References 14 publications

Temporal and Spatial Melanoma Trends in Austria: An Ecological Study

Temporal and Spatial Melanoma Trends in Austria: An Ecological Study

Quality of life in non‐melanoma skin cancer

A systematic review on methods used to evaluate patient preferences in psoriasis treatments

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