Background: To understand the willingness of nurses from Tangshan City to undergo Coronavirus disease 2019 (COVID-19) vaccination and identify its influencing factors.Methods: In January 2021, 255 nurses from five medical institutions across Tangshan City were investigated through convenience sampling on a network platform of Sojump. Furthermore, SPSS Statistics v24.0 software was used for general descriptive analysis, rank-sum test and binary logistic regression analysis to analyse willingness rates for COVID-19 vaccination and corresponding influencing factors.Results: A total of 255 valid questionnaires were collected (recovery rate, 85.71%). Among the 255 nurses surveyed, the willingness rate was 67.8%. The major reasons for willingness to undergo COVID-19 vaccination included a high-risk work environment necessitating COVID-19 vaccination (87.9%), expected benefits to themselves and others (72.8%) and worries regarding COVID-19 infection (66.5%). Meanwhile, reasons for unwillingness to undergo COVID-19 vaccination in 82 nurses included concerns regarding safety (89.0%), effectiveness (62.2%) and the possibility of fake vaccines (32.9%). Furthermore, among the 255 nurses, 43.9% were willing to recommend COVID-19 vaccination (n = 112), with the main reasons being prevention of COVID-19 infection (100.0%) and herd immunity via universal vaccination (90.2%). Moreover, the main reasons for unwillingness to recommend COVID-19 vaccination included poor popularity and wait-and-see attitude (85.3%) and hesitancy to recommend given the absence of COVID-19 vaccines (67.1%). With regard to attitude towards COVID-19 vaccine marketing, 149 (58.5%) nurses expressed favour, 101 (39.6%) nurses took a neutral position and 5 (1.9%) expressed displeasure. Univariate analysis revealed that male nurses, as well as those who actively inquired and sought information on COVID-19 vaccines, had significantly higher willingness for vaccination compared to female nurses and those not actively seeking information (P < 0.05). Meanwhile, binary logistic regression analysis indicated that gender, degree of education, working years and active inquiry or search for vaccine information were associated with willingness for COVID-19 vaccination (P < 0.05).Conclusion: This study highlights the need for further improving the willingness of nurses from Tangshan City to undergo and recommend COVID-19 vaccination. Relevant departments should therefore publicise information regarding COVID-19 vaccines for medical staff to ensure the safe and effective promotion thereof.