Willie Sutton Was Right: It’s Time to Turn to the Synovium to Drive Rheumatoid Arthritis Therapy

Ruderman, Eric; Mandelin, Arthur M.; Perlman, Harris

doi:10.3899/jrheum.161285

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2018

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“…In the past few years, oncologists have moved from general chemotherapy to personalized treatment based on genetic measurements. Treatment of rheumatic disease can follow a similar path as ongoing and future studies pave the way forward [46]. For example, measuring OSM gene expression in IBD patients may promise to predict successful response to anti-TNF therapy [21].…”

Section: Resultsmentioning

confidence: 99%

Functional genomics of stromal cells in chronic inflammatory diseases

Slowikowski

Wei

Brenner

et al. 2018

Current Opinion in Rheumatology

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Stromal cells form the microenvironment of inflamed and diseased tissues. Functional genomics is producing an increasingly detailed view of subsets of stromal cells with pathogenic functions in rheumatic diseases and cancer. Future genomics studies will discover disease mechanisms by perturbing molecular pathways with chemokines and therapies known to affect patient outcomes. Functional genomics studies with large sample sizes of patient tissues will identify patient subsets with different disease phenotypes or treatment responses.

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Section: Resultsmentioning

confidence: 99%