William Stark (1740–1770): His Life, Manuscript and Death

Doyle, Leslie

doi:10.1177/096777200000800304

Cited by 2 publications

(1 citation statement)

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“…It was not until the precise assessment of the tuberculous lesions in the lung tissue that the disease was clearly defined, and its symptoms brought into a single category. It was William Stark, in his observations published by James C. Smith 18 years after his death [12], who proposed the evolution of the pulmonary nodules into ulcers and cavities, thus justifying the different manifestations of the disease in a single location of the lesion. These lesions were further studied in microscopic detail until, in 1882, Robert Koch identified the microbiological cause, the bacillus Mycobacterium tuberculosis [10].…”

Section: Patients Torn To Piecesmentioning

confidence: 99%

Systems Precision Medicine: Putting the Pieces Back Together

Farina

2023

Systems

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Systems precision medicine is an interdisciplinary approach that recognises the complexity of diseases and emphasises the integration of clinical knowledge, multi-omics data, analytical models, and the expertise of physicians and data analysts to personalise the care pathway in complex diseases, such as cancer or diabetes. The aim is to gain a comprehensive understanding of diseases by analysing individual components and identifying relevant aspects for therapy and diagnosis. Key components, their interactions and emerging patterns can be studied using statistical, mathematical and computational tools. The combination of data analysis and clinical evaluation is crucial to effective decision-making, emphasising the need for an integrative approach rather than relying on data alone. Therefore, the crucial point discussed in this paper is that the “computational” part and the “artistic” part (i.e., the physician’s intuition) cannot be separated, and therefore, systems precision medicine can be configured as a collective work of art, involving not only different medical professionals but also, and above all, professional data analysts. The work is “artistic” because data and mathematics alone, without medical knowledge of the context, are not enough. But the work is also “collective” in the sense that it must be the place of cultural integration between the professional intuition of the physician, which cannot be translated into mathematical formulas, and the ability to extract information from multi-omics data of the data analysts, who instead use formal and computational mathematical methods. However, to drive the medical revolution and reassemble a patient’s parts, data analysts need to be involved in the hospital context, and precision medicine physicians should embrace data analytical perspectives. This will require ongoing dialogue, new languages of communication, and education that promotes continuous learning and collaboration between professions, fostering a new level of interdisciplinary collaboration for personalised care.

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Section: Patients Torn To Piecesmentioning

confidence: 99%