Willed-movement training reduces motor deficits and induces a PICK1-dependent LTD in rats subjected to focal cerebral ischemia

Tang, Qinglin; Tan, Lihong; Yang, Xinming; Shen, Qin; Huang, Xiaosong; Wang, Gaiqing; Chen, Hengheng; Nie, Jingjing; Li, Simin; Wu, Lixiang

doi:10.1016/j.bbr.2013.08.039

Cited by 13 publications

(20 citation statements)

References 32 publications

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“…PICK1is an AMPAR-binding protein, serving an essential role in regulating LTD in cerebral and hippocampal synapses. A previous study identified that WM training induces a PICK1-dependent LTD in rats subjected to focal cerebral ischemia (30). In the present study, it was observed that GRASP-1 and PICK1 expression were induced by WM training, suggesting that WM training is involved in LTP and LTD in regulating synaptic plasticity.…”

Section: Discussionsupporting

confidence: 69%

“…In a previous study, it was identified that the signal transducer and activator of transcription 3 (STAT3) pathway was involved in the regulation of BDNF, PICK1 and SYP and mediates the improvements in neuroplasticity that result from WM training (30). The present study additionally identified that the ERK/CREB pathway was notably activated following WM training.…”

Section: Discussionsupporting

confidence: 59%

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Effect of willed movement training on neurorehabilitation after focal cerebral ischemia and on the neural plasticity-associated signaling pathway

et al. 2017

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Neurorehabilitation training is a therapeutic intervention for the loss of neural function induced by focal cerebral ischemia, however, the effect varies depending on the neurorehabilitation exercises. Willed movement (WM) training is defined as task‑oriented training, which increases enthusiasm of patients to accomplish a specific task. The current study was performed to the evaluate effect of WM training on neurorehabilitation following focal cerebral ischemia, and further investigate the influence on neural plasticity‑associated signaling pathway. Sprague‑Dawley rats following temporary middle cerebral artery occlusion (tMCAO) were randomly divided into four groups: tMCAO (no rehabilitation training), CR (control rehabilitation), EM (environmental modification) and WM groups. Rats in the CR group were forced to exercise (running) in a rotating wheel. In the WM group, food was used to entice rats to climb on a herringbone ladder. Herringbone ladders were also put into the cages of the rats in the CR and EM groups, however without the food attraction. WM group exhibited an improvement in neurobehavioral performance compared with other groups. TTC staining indicated an evident reduction in brain damage in the WM group. There were increased synaptic junctions following WM training, based on the observations of transmission election microscopy. Investigation of the molecular mechanism suggested that WM training conferred the greatest effect on stimulating the extracellular signal‑related kinase (ERK)/cyclic adenosine monophosphate response element‑binding protein 1 (CREB) pathway and glutamate receptor 2 (GluR2)/glutamate receptor interacting protein 1‑associated protein 1 (GRASP‑1)/protein interacting with C‑kinase 1 (PICK1) cascades among groups. Collectively, the improvement of neurobehavioral performance by WM training following tMCAO is suggested to involve the ERK/CREB pathway and GluR2/GRASP‑1/PICK1 cascades. The present study provided a preliminary foundation for future research on the therapeutic effect of WM training against stroke‑induced neuron damage.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionsupporting

confidence: 59%

Effect of willed movement training on neurorehabilitation after focal cerebral ischemia and on the neural plasticity-associated signaling pathway

et al. 2017

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“…[48] As an example of an AMPA receptor dependent protein, there is the PICK1 (Protein Interacting with C kinase 1), which has been proven to be one of the key proteins in the regulation of synaptic plasticity. [49][50][51]60] A highlighted approach is the contralesional brain compensation after an ischemic damage. Some of the contralesional changes are associated with enhanced ipsilesional function.…”

Section: Endogenous Conformationsmentioning

confidence: 99%

“…It can be inferred that a 'therapeutic' effect that might be due, at least partially, to stimulation of LTD-related synaptic neuroplasticity. [60] It is noted, also, that melanocortins afford a strong neuroprotection against damage consequent to global or focal cerebral ischemia in gerbils and rats. They act by blocking several ischemia-related mechanisms of damage, through the activation of central nervous system (CNS) melanocortin MC 4 receptors, and in a broad therapeutic treatment window.…”

Section: Endogenous Conformationsmentioning

confidence: 99%

“…[120] In relation with it, it was performed a new way to improve the motor ability following a cerebral ischemia, such as the Willed-movement (WM) training, which is defined as a voluntary motor training through which an individual pays attention to a goal and makes an effort to accomplish it. [110,60] WM therapy [111,60] involves more coordinated activities of the whole body and limbs. [60] Nevertheless, some studies show that in a traumatic brain injury model, animals receiving voluntary exercise early post-injury (days 0-6) were found to have reduced expression of plasticity-related proteins in the hippocampus and worsened water maze performance compared to animals exercised between 14 and 20 days after injury.…”

Section: Behavioral Determinantsmentioning

confidence: 99%

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The importance of neuronal plasticity in the prognosis of cases of cerebral ischemia: a systematic review

Pimental¹,

Santos²,

Gonçalves³

et al. 2015

Int Arch Med

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Background: Neuronal plasticity is the capacity that the neurons have to make new connections and enable new ways of transmitting information. Under this context, new methodologies are being addressed in order to measure how important this neuronal capacity is in the process of full recovery of learning in subjects who suffered damage from cerebral ischemia. Methods: A systematic review was performed on the online databases: Medical Literature Analysis and Retrieval System Online (ME-DLINE) and Scopus, between 1998 and 2014. The MeSH (Medical Subject Headings) descriptors used in this review were: "neuronal plasticity", "brain ischemia" and "learning". We found 164 articles that, when screened, resulted in 46 articles that met the criteria of evidence and were included in this review. Results: There are several ways available in the literature to increase neuronal plasticity to keep the learning process after bad conformations resulting from cerebral ischemia. We highlighted the most elucidated: those promoted by SMe1EC2 antioxidant, which brings therapeutic benefits when neuronal plasticity is impaired; and Atorvastatin, a statin which facilitates recovery of spatial learning. It is further observed that the body has a number of intrinsic devices,

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Modulation of Synaptic Plasticity by Exercise Training as a Basis for Ischemic Stroke Rehabilitation

Nie

Yang

2016

Cell Mol Neurobiol

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In recent years, rehabilitation of ischemic stroke draws more and more attention in the world, and has been linked to changes of synaptic plasticity. Exercise training improves motor function of ischemia as well as cognition which is associated with formation of learning and memory. The molecular basis of learning and memory might be synaptic plasticity. Research has therefore been conducted in an attempt to relate effects of exercise training to neuroprotection and neurogenesis adjacent to the ischemic injury brain. The present paper reviews the current literature addressing this question and discusses the possible mechanisms involved in modulation of synaptic plasticity by exercise training. This review shows the pathological process of synaptic dysfunction in ischemic roughly and then discusses the effects of exercise training on scaffold proteins and regulatory protein expression. The expression of scaffold proteins generally increased after training, but the effects on regulatory proteins were mixed. Moreover, the compositions of postsynaptic receptors were changed and the strength of synaptic transmission was enhanced after training. Finally, the recovery of cognition is critically associated with synaptic remodeling in an injured brain, and the remodeling occurs through a number of local regulations including mRNA translation, remodeling of cytoskeleton, and receptor trafficking into and out of the synapse. We do provide a comprehensive knowledge of synaptic plasticity enhancement obtained by exercise training in this review.

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Willed-movement training reduces motor deficits and induces a PICK1-dependent LTD in rats subjected to focal cerebral ischemia

Cited by 13 publications

References 32 publications

Effect of willed movement training on neurorehabilitation after focal cerebral ischemia and on the neural plasticity-associated signaling pathway

Effect of willed movement training on neurorehabilitation after focal cerebral ischemia and on the neural plasticity-associated signaling pathway

The importance of neuronal plasticity in the prognosis of cases of cerebral ischemia: a systematic review

Modulation of Synaptic Plasticity by Exercise Training as a Basis for Ischemic Stroke Rehabilitation

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