“Willed action”: A functional MRI study of the human prefrontal cortex during a sensorimotor task

Hyder, Fahmeed; Phelps, Elizabeth A.; Wiggins, Christopher J.; LaBar, Kevin S.; Blamire, Andrew M.; Shulman, Robert G.

doi:10.1073/pnas.94.13.6989

Cited by 70 publications

(53 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Such cerebellar activation was not documented when observation was not aimed toward imitation (Chaminade et al, 2002;Decety & Grèzes, 1999). The interplay between cerebellar and prefrontal areas, supported also by their important anatomofunctional connections (Middleton & Strick, 2001), allows for speculation that the cerebellum and prefrontal cortex interact in planning actions-that is, the former permits acquisition of efficient procedural competencies and the latter provides flexibility among already acquired and stored solutions (Pochon et al, 2001;Spence, Hirsch, Brooks, & Grasby, 1998;Hyder et al, 1997;Frith, Friston, Liddle, & Frackowiak, 1991).…”

Section: Discussionmentioning

confidence: 99%

The What and How of Observational Learning

Torriero

Oliveri

Koch

et al. 2007

Journal of Cognitive Neuroscience

View full text Add to dashboard Cite

Abstract& Neuroimaging evidence increasingly supports the hypothesis that the same neural structures subserve the execution, imagination, and observation of actions. We used repetitive transcranial magnetic stimulation (rTMS) to investigate the specific roles of cerebellum and dorsolateral prefrontal cortex (DLPFC) in observational learning of a visuomotor task. Subjects observed an actor detecting a hidden sequence in a matrix and then performed the task detecting either the previously observed sequence or a new one. rTMS applied over the cerebellum before the observational training interfered with performance of the new sequence, whereas rTMS applied over the DLPFC interfered with performance of the previously observed one. When rTMS applied over cerebellar or prefrontal site was delivered after the observational training, no influence was observed on the execution of the task. These results furnish new insights on the neural circuitry involved in the single component of observational learning and allow us to hypothesize that cerebellum and DLPFC interact in planning actions, the former by permitting the acquisition of procedural competencies and the latter by providing flexibility among already acquired solutions. &

show abstract

Section: Discussionmentioning

confidence: 99%

The What and How of Observational Learning

Torriero

Oliveri

Koch

et al. 2007

Journal of Cognitive Neuroscience

View full text Add to dashboard Cite

show abstract

“…Consequently, it is possible that the observed effect was caused by the modulation of PFC on the primary motor cortex without the involvement of the PMC mirror system. PFC plays a key role in the guidance of complex behaviors such as working memory (Elliott et al, 2000;Fuster, 1989;Miller, 2000;Petrides & Pandya, 1999) or decision-making tasks (Frith, 1991;Hyder et al, 1997;Jahanshahi & Frith, 1998). PFC is recruited either when different alternative responses have to be chosen or when an action has to be selected and performed (Miller, 2000).…”

Section: Interaction Between Prefrontal and Premotor Corticesmentioning

confidence: 99%

Release of premotor activity after repetitive transcranial magnetic stimulation of prefrontal cortex

Gangitano

Mottaghy

Pascual‐Leone

2008

Social Neuroscience

View full text Add to dashboard Cite

In the present study we aimed to explore by means of repetitive transcranial magnetic stimulation (rTMS) the reciprocal influences between prefrontal cortex (PFC) and premotor cortex (PMC). Subjects were asked to observe on a computer monitor different pictures representing manipulations of different kind of tools. They had to produce a movement (go condition) or to keep the resting position (no-go condition) at the appearance of different cue signals represented by different colors shown alternatively on the hands manipulating the tools or on the picture background. Motor evoked potentials (MEPs) were collected at the offset of the visual stimuli before and after a 10 minute, 1 Hz rTMS train applied to the dorsolateral PFC (Experiment 1), to the PMC (Experiment 2) or to the primary motor cortex (Experiment 3). Following rTMS to the PFC, MEPs increased in the go condition when the cue for the go command was presented on the hand. In contrast, following rTMS to the PMC, in the same condition, MEPs were decreased. rTMS to the primary motor cortex did not produce any modulation. Results are discussed according to the presence of a visual-motor matching system in the PMC and to the role of the PFC in the attention-related processes. We hypothesize that the perceptual analysis for action selection within the PFC was modulated by rTMS and its temporary functional inactivation in turn influenced the premotor areas for motor programming

show abstract

“…Each linearly interpolated t map was overlaid onto the corresponding anatomical image to form the SAPs in the whole OB, which revealed the location of activity in the bulbar layers: the olfactory nerve layer (ONL), glomerular layer (GL), and external plexiform layer (EPL). Layer segmentation in the rat OB is based on the contrast-to-noise ratio across layers, which are similar in magnitude of contrast-to-noise in anatomical images of the human brain that distinguish gray from white matter (10). The MRI layer segmentation is based on a priori information from histological staining (12).…”

Section: Anatomical and Fmrimentioning

confidence: 99%

“…Details of data processing have been described (6,10). Briefly, after conversion of sequentially sampled data and two-dimensional Fourier transformation (11), head movement artifacts were assessed by a center-of-mass analysis.…”

Section: Anatomical and Fmrimentioning

confidence: 99%

Assessment and discrimination of odor stimuli in rat olfactory bulb by dynamic functional MRI

Kida²,

Hyder³

et al. 2000

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

115

118

View full text Add to dashboard Cite

Dynamic blood oxygenation level-dependent functional MRI was applied at 7 T in the rat olfactory bulb (OB) with pulsed delivery of iso-amyl acetate (IAA) and limonene. Acquisition times for singleslice and whole OB data were 8 and 32 s, respectively, with spatial resolution of 220 ؋ 220 ؋ 250 m. On an intrasubject basis, short IAA exposures of 0.6 min separated by 3.5-min intervals induced reproducible spatial activity patterns (SAPs) in the olfactory nerve layer, glomerular layer, and external plexiform layer. During long exposures (Ϸ10 min), the initially dominant dorsal SAPs declined in intensity and area, whereas in some OB regions, the initially weak ventral͞lateral SAPs increased first and then decreased. The SAPs of different concentrations were topologically similar, which implies that whereas an odor at various concentrations activates the same subsets of receptor cells, different concentrations are assessed and discriminated by variable magnitudes of laminarspecific activations. IAA and limonene reproducibly activated different subsets of receptor cells with some overlaps. Whereas qualitative topographical agreement was observed with results from other methods, the current dynamic blood oxygenation level-dependent functional MRI results can provide quantitative SAPs of the entire OB.blood oxygenation level-dependent ͉ functional mapping ͉ olfactory bulb I n mammals, olfactory behaviors such as determination of food palatability and searching require accurate assessment and discrimination of different odor types, concentrations, and exposure duration (1). Distinctions between these behavioral tasks are believed to rely on a spatial-encoding mechanism in which different odor and concentrations evoke spatial activity patterns (SAPs) in the olfactory bulb (OB). The SAPs are derived from functionally induced activity in olfactory receptor neurons that synapse at specific glomeruli (2).Insights into the coding of olfactory information have been partially inferred from SAPs in the OB, where the data can be obtained by various methods: 2-deoxyglucose autoradiography (3), electrophysiology (4), c-fos expression (5), functional MRI (fMRI) (6), and optical imaging of voltage-sensitive dyes (7) or intrinsic signals (8). Experimental limitations of each method affect data interpretations because each method maps a specific signal. Certain experimental criteria have to be met for olfactory perception to be systematically and ideally derived from the functional architecture revealed by the SAPs: (i) the neuroanatomy of the whole OB has to be mapped; (ii) the dynamic nature of SAPs in the whole OB has to be mapped with both high spatial and temporal resolutions; (iii) laminar-specific activations in the different layers have to be quantitated; and (iv) reproducibility of SAPs has to be established in a quantitative manner such that the effects of stimulus parameters (e.g., odor type, concentration, and exposure duration) can be easily identified and separated. If each criterion is met on an intrasubject basis by a par...

show abstract

“Willed action”: A functional MRI study of the human prefrontal cortex during a sensorimotor task

Abstract: Functional MRI (fMRI) was used to examine human brain activity within the dorsolateral prefrontal cortex during a sensorimotor task that had been proposed to require selection between several responses, a cognitive concept termed ''willed action'' in a positron emission tomography

Cited by 70 publications

References 28 publications

The What and How of Observational Learning

The What and How of Observational Learning

Release of premotor activity after repetitive transcranial magnetic stimulation of prefrontal cortex

Assessment and discrimination of odor stimuli in rat olfactory bulb by dynamic functional MRI

Contact Info

Product

Resources

About