Will Smiley. From Slaves to Prisoners of War: The Ottoman Empire, Russia, and International Law.

Frary, Lucien J.

doi:10.1093/ahr/rhz759

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“…The pharmacological and industrial importance of the synthesized polyfunctionalized 2‐oxo‐nicotinonitrile is a resuming field of the scientific attention; this is due to the existence of this class of pyridine nucleus in various biologically active and applicable compounds . In the last 10 years, the natural compounds containing 2‐pyridone moiety have emerged as an antimycotic , an effective antitumor , antiviral , anti‐HIV , and mental disorder drugs. Some 2‐oxo‐nicotinonitrile, like milrinone, is quite founded active vasodilatory and cardiotonic agents , and other 2‐pyridone derivatives act as phosphodiesterase 3 inhibitors .…”

Section: Introductionmentioning

confidence: 99%

A Direct Synthesis for a New Series of 2‐Oxo(thioxo)nicotinonitrile Nucleosides as Antimicrobial Agents

El‐Sayed

EL-Torky

Moustafa

2018

Journal of Heterocyclic Chem

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A facile synthesis of a new series of cyclic and acyclic nucleosides of polyfunctionalized 2‐oxo(thioxo)nicotinonitrile derivatives 1 and 2 was performed. Glycosylation of 2‐pyridone 1 and 2‐thiopyridone 2 with glycosyl/galactosyl bromides in the existence of KOH afforded the N‐nucleoside and S‐nucleoside analogues 3, 5, 7, and 9, respectively. Deacetylation of nucleosides 3, 5, 7, and 9 gave the deacetylated nucleosides 4, 6, 8, and 10, respectively. Alkylation of 2‐pyridone 1 with glycone analogues [namely, 4‐bromobutyl acetate, (2‐acetoxyethoxy)methyl bromide, 3‐chloropropane‐1,2‐diol, and allyl and / propargyl bromides] in the existence of K2CO3 afforded the corresponding O‐acyclic nucleoside analogues 11, 13, and 15–17, respectively. Finally, treating of compounds 11 and 13 with a small amount of Et3N tolerated the 6‐hydroxy deacetylated derivatives 12 and 14, respectively. The synthesized nucleosides and alkylated products were tested against Gram (+ve) (Staphylococcus aureus and Bacillus cereus) and (Pseudomonas aeruginosa and Escherichia coli) as Gram (−ve) and Fungi (Aspergillus flavus and Aspergillus niger) and showed moderate antibacterial and antifungal activity.

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