Will primary central nervous system lymphoma be the most frequent brain tumor diagnosed in the year 2000?

Corn, Benjamin W.; Marcus, Sue M.; Topham, Allan

doi:10.1002/(sici)1097-0142(19970615)79:12<2409::aid-cncr17>3.3.co;2-2

Cited by 39 publications

(51 citation statements)

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“…In the early 1970s, PCNSL was a rare tumour (Henry et al, 1974). The incidence of PCNSL increased from 2.5 cases per 10 million population in 1973 to 30 in 1991-1992; (Corn et al, 1997) it was increasingly diagnosed in the immunodeficient and immunosuppressed patients as well as in the immunocompetent (Schabet ,1999). The increase in incidence of PCNSL had surpassed the milder increase in systemic lymphomas and could not be attributed solely to technological advances in radiology and stereotactic neurosurgery (Olson et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Primary Central Nervous System Lymphoma: A Clinicopathological and Cytomorpholgical Study from A Tertiary Care Centre in Chennai, India

Ambroise

Ghosh²,

Mallikarjuna³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: The aim of this study was to analyze the clinicopathological and immunohistochemical features of primary central nervous system lymphoma (PCNSL) cases occurring in Indian patients and also study the utility of the crush smear preparation in intraoperative diagnosis. Materials and Methods: The immune status, clinical, radiological details, immunohistochemical profile, histopathological findings and cytological features in smear preparation of 32 cases of PCNSL were analyzed. Patients with systemic NHL and skull-base lymphomas were excluded. Results: The mean age of our patients was 52 years with a male: female ratio 1:1. A periventricular location was found in 62.5% of patients. None of our PCNSL cases were associated with AIDS. All cases except one were diffuse large B-cell lymphomas. Intraoperative diagnosis using crush smears allowed correct prediction in 93% of cases. Conclusions: Our study shows that PCNSL is seen predominantly in immunocompetent patients in India .The age of presentation is relatively young as compared to the West. Our study also stresses the utility of crush smear preparation in establishing an intraoperative diagnosis.

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Section: Introductionmentioning

confidence: 99%

Primary Central Nervous System Lymphoma: A Clinicopathological and Cytomorpholgical Study from A Tertiary Care Centre in Chennai, India

Ambroise

Ghosh²,

Mallikarjuna³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…The incidence of PCNSL has increased over the past few decades to 6.6% 3 of primary intracranial tumours in some neuropathological series [3][4][5] in both immunocompromised and immunocompetent patients. This is only in part because of the HIV-1 epidemic, as there also appears to be an increasing incidence of sporadic, non-HIV-related disease.…”

Section: Introductionmentioning

confidence: 99%

Intraocular lymphoma: a series of 14 patients with clinicopathological features and treatment outcomes

Hoffman

McKelvie

Hall

et al. 2003

Eye

137

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Aims To assess the clinical features, pathology, mortality (systemic outcome) and ocular complications (visual outcome) of a cohort of patients treated for intraocular lymphoma. Methods Retrospective case analysis of medical records and review of pathology of a consecutive series of patients presenting with intraocular lymphoma in Melbourne over 11 years between 1990 and 2000. Categorical factors influencing survival were examined by the Kaplan-Meier estimator and groups compared with the log rank test.

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“…The cause for the increased incidence in immunocompetent patients is unknown. 14 Based on the statistics of PCNSL, 15,16 we estimate conservatively that in the past 3 years there were at least 100 new cases of PIOL in the United States.…”

Section: Epidemiologymentioning

confidence: 99%

Molecular pathology of primary intraocular lymphoma

Chan¹

2004

American Journal of Ophthalmology

129

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Will primary central nervous system lymphoma be the most frequent brain tumor diagnosed in the year 2000?

Cited by 39 publications

References 1 publication

Primary Central Nervous System Lymphoma: A Clinicopathological and Cytomorpholgical Study from A Tertiary Care Centre in Chennai, India

Primary Central Nervous System Lymphoma: A Clinicopathological and Cytomorpholgical Study from A Tertiary Care Centre in Chennai, India

Intraocular lymphoma: a series of 14 patients with clinicopathological features and treatment outcomes

Molecular pathology of primary intraocular lymphoma

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