Will Genetic Testing for Complex Diseases Increase Motivation to Quit Smoking? Anticipated Reactions in a Survey of Smokers

Sanderson, Saskia C.; Wardle, Jane

doi:10.1177/1090198105278756

Cited by 35 publications

(34 citation statements)

References 32 publications

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“…Vignette studies, where participants 'imagine' receiving genetic test feedback, were a first step. They typically find that people imagine that a higher risk results would make them more motivated to change their behavior, and there is little evidence of negative emotional or motivational outcomes (Sanderson and Wardle 2005;Frosch et al 2005;Meisel et al 2012;Meisel and Wardle 2013). However, although these results are encouraging, they cannot be assumed to generalize to real feedback conditions.…”

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confidence: 83%

Responses to FTO genetic test feedback for obesity in a sample of overweight adults: a qualitative analysis

Meisel

Wardle

2013

Genes Nutr

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confidence: 83%

Responses to FTO genetic test feedback for obesity in a sample of overweight adults: a qualitative analysis

Meisel

Wardle

2013

Genes Nutr

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“…While a positive test may aid behavioural change a negative test may give false reassurance and reduce the motivation for behavioural change. 20 As accessibility to genetic information becomes more widespread, it will be crucial to understand the psychological impact of this information and to determine whether it can lead to behavioural change that would justify the costs of largescale genetic testing. Indeed, genetic testing for AMD is already commercially available.…”

Section: Introductionmentioning

confidence: 99%

Can genetic risk information for age-related macular degeneration influence motivation to stop smoking? A pilot study

Rennie

Stinge

King

et al. 2011

Eye

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Aims Smoking can increase the risk of macular degeneration and this is more than additive if a person also has a genetic risk. The purpose of this study was to examine whether knowledge of genetic risk for age-related macular degeneration (AMD) could influence motivation to quit smoking. Methods A questionnaire-based study of hypothetical case scenarios given to 49 smokers without AMD. Participants were randomly allocated to a generic risk, high genetic risk, or low genetic risk of developing AMD scenario. Results Forty-seven percent knew of the link between smoking and eye disease. In all, 76%, 67%, and 46% for the high risk, generic, and low risk groups, respectively, would rethink quitting (P for trend ¼ 0.082). In all, 67%, 40%, and 38.5%, respectively, would be likely, very likely, or would definitely quit in the following month (P for trend ¼ 0.023). Few participants (o16% of any group) were very likely to or would definitely attend a quit smoking session with no difference across groups. In all, 75.5% of participants would consider taking a genetic test for AMD. Conclusion In this pilot study, a trend was seen for the group given high genetic risk information to be more likely to quit than the generic or low genetic risk groups. Participants were willing to take a genetic test but further work is needed to address the cost benefits of routine genetic testing for risk of AMD. More generic risk information should be given to the public, and health warnings on cigarette packets that 'smoking causes blindness' is a good way to achieve this.

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“…27,28 Indeed, uptake rates may reflect quit motivation. 29 Finally, although Internet use among Americans has reached 75%, 30 issues of frequency of access and comfort with the Internet may also modify engagement. 31 Second, it is vital to assess whether individuals can make informed decisions using a web-based approach.…”

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confidence: 99%

The feasibility of online genetic testing for lung cancer susceptibility: uptake of a web-based protocol and decision outcomes

O’Neill

White

Sanderson

et al. 2008

Genetics in Medicine

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Purpose: To examine the feasibility of offering genetic susceptibility testing for lung cancer (GSTM1) via the Internet to smokers who were blood relatives of patients with lung cancer. Outcomes include proportion who logged on to the study website to consider testing, made informed decisions to log on and to be tested. Methods: Baseline measures were assessed via telephone survey. Participants could choose to log on to the study website; those who did were offered testing. Informed decisions to log on and to be tested were indicated by concordance between the decision outcome and test-related attitudes and knowledge. Results: Three hundred four relatives completed baseline interviews. One hundred sixteen eligible relatives expressed further interest in receiving information via the web. Fifty-eight logged on and 44 tested. Those logging on expressed greater quit motivation, awareness of cancer genetic testing, and were more likely to be daily Internet users than those who did not log on. Approximately half of the sample made informed decisions to log on and to be tested. Conclusion: Interest in a web-based protocol for genetic susceptibility testing was high. Internet-delivered decision support was as likely as other modalities to yield informed decisions. Some subgroups may need additional support to improve their decision outcomes. Genet Med 2008:10(2):121-130. Key Words: Internet, genetic testing, test uptake, decision making, GSTM1, lung cancerAvailability of genetic susceptibility testing for common diseases is likely to increase as the evidence supporting gene-disease associations continues to grow. 1 There is a good deal of optimism that such testing might be beneficial for motivating individuals to adopt healthy lifestyles. 2 Genetic susceptibility testing for lung cancer has been suggested as a means to motivate smoking cessation. 3 However, a challenge for integrating such testing into smoking cessation or other behavior change interventions is that most of these interventions are self-directed, low intensity, and obliged to be low in cost to maximize dissemination. 4 Before any such integration, the feasibility of offering genetic susceptibility testing and conveying risk feedback, via alternate, user-friendly, self-directed delivery models, such as the Internet, must be assessed. 5 To our knowledge, no studies to date have offered genetic susceptibility testing using solely a web-based format. This is despite the fact that 75% of Americans use the Internet on a regular basis, and the impact of Internet applications on physician-patient communication and health care delivery continues to expand. 6 -8 Though no studies have examined delivery of genetic test results via the Internet, research to date supports the examination of alternate delivery models in some settings. For example, one trial delivered genetic susceptibility testing for alpha-1 antitrypsin deficiency, a smoking-linked form of emphysema, via the mail to unaffected individuals with some success. 9,10 Results of another trial, in which ...

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Will Genetic Testing for Complex Diseases Increase Motivation to Quit Smoking? Anticipated Reactions in a Survey of Smokers

Cited by 35 publications

References 32 publications

Responses to FTO genetic test feedback for obesity in a sample of overweight adults: a qualitative analysis

Responses to FTO genetic test feedback for obesity in a sample of overweight adults: a qualitative analysis

Can genetic risk information for age-related macular degeneration influence motivation to stop smoking? A pilot study

The feasibility of online genetic testing for lung cancer susceptibility: uptake of a web-based protocol and decision outcomes

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