Will chronic e-cigarette use cause lung disease?

Rowell, Temperance R; Tarran, Robert

doi:10.1152/ajplung.00272.2015

Cited by 99 publications

(80 citation statements)

References 160 publications

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“…Electronic nicotine delivery systems (e-cigarettes) were designed to deliver nicotine without tobacco combustion and are used in smoke cessation; however, until recently they were unregulated by the US FDA [118,119]. While e-cigarettes are marketed as a safer alternative to tobacco smoking, they contain nicotine and flavorants and the long-term effects are unknown.…”

Section: Resultsmentioning

confidence: 99%

The association between environmental tobacco smoke exposure and childhood respiratory disease: a review

Vanker

Gie

Zar

2017

Expert Review of Respiratory Medicine

135

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Introduction: Childhood respiratory illness is a major cause of morbidity and mortality particularly in low and middle-income countries. Environmental tobacco smoke (ETS) exposure is a recognised risk factor for both acute and chronic respiratory illness.Areas covered: The aim of this paper was to review the epidemiology of ETS exposure and impact on respiratory health in children. We conducted a search of 3 electronic databases of publications on ETS and childhood respiratory illness from 1990–2015. Key findings were that up to 70% of children are exposed to ETS globally, but under-reporting may mask the true prevalence. Maternal smoking and ETS exposure influence infant lung development and are associated with childhood upper and lower respiratory tract infection, wheezing or asthma. Further, exposure to ETS is associated with more severe respiratory disease. ETS exposure reduces lung function early in life, establishing an increased lifelong risk of poor lung health.Expert commentary: Urgent and effective strategies are needed to decrease ETS exposure in young children to improve child and long-term lung health in adults especially in low and middle income countries where ETS exposure is increasing.

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Section: Resultsmentioning

confidence: 99%

The association between environmental tobacco smoke exposure and childhood respiratory disease: a review

Vanker

Gie

Zar

2017

Expert Review of Respiratory Medicine

135

View full text Add to dashboard Cite

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“…There has been little study of the chronic health effects of e-cigarettes (3,4). However, ecigarettes produce exposures with known toxicity to the lung.…”

mentioning

confidence: 99%

Electronic Cigarette Use and Respiratory Symptoms in Adolescents

McConnell

Barrington‐Trimis

Wang

et al. 2017

Am J Respir Crit Care Med

300

224

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Rationale: Rates of adolescent electronic (e-) cigarette use are increasing, but there has been little study of the chronic effects of use.Components of e-cigarette aerosol have known pulmonary toxicity.Objectives: To investigate the associations of e-cigarette use with chronic bronchitis symptoms and wheeze in an adolescent population.Methods: Associations of self-reported use of e-cigarettes with chronic bronchitic symptoms (chronic cough, phlegm, or bronchitis) and of wheeze in the previous 12 months were examined in 2,086 Southern California Children's Health Study participants completing questionnaires in 11th and 12th grade in 2014.Measurements and Main Results: Ever e-cigarette use was reported by 502 (24.0%), of whom 201 (9.6%) used e-cigarettes during the last 30 days (current users). Risk of bronchitic symptoms was increased by almost twofold among past users (odds ratio [OR], 1.85; 95% confidence interval [CI], 1.37-2.49), compared with never-users, and by 2.02-fold (95% CI, 1.42-2.88) among current users. Risk increased with frequency of current use (OR, 1.66; 95% CI, 1.02-2.68) for 1-2 days and 2.52 (95% CI, 1.56-4.08) for 3 or more days in past 30 days compared with never-users. Associations were attenuated by adjustment for lifetime number of cigarettes smoked and secondhand smoke exposure. However, risk of bronchitic symptoms among past e-cigarette users remained elevated after adjustment for relevant potential confounders and was also observed among never-cigarette users (OR, 1.70; 95% CI, 1.11-2.59). There were no statistically significant associations of e-cigarette use with wheeze after adjustment for cigarette use.Conclusions: Adolescent e-cigarette users had increased rates of chronic bronchitic symptoms. Further investigation is needed to determine the long-term effects of e-cigarettes on respiratory health.

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“…5). Taking into account the fact that the temperature of electronic cigarette heating unit does not exceed 250 o C [29], the data obtained at lower temperatures only are of some practical interest. In the IR spectra of ECIG liquid at t < 250 o C one could observe water, carbon dioxide, propylene glycol, glycerol and nothing more.…”

Section: Resultsmentioning

confidence: 99%

Thermal Decomposition of Electronic Cigarette Liquid. Ir Study

Гамов¹,

Смирнов²,

Aleksandriiskii³

et al. 2017

IVUZKKT

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Under the conditions which are characteristic for electron cigarette usage chemicals containing in cigarettes (nicotine (0-2% weight usually), propylene glycol, glycerol, distilled water and different flavors) are capable to thermal decomposing and the products of decomposition could react with each other. Thus, harmful compounds and carcinogens may evolve. Literature describes a number of experiments detecting the formation of tobacco-specific nitrosamines, diacetyl and acetyl propionyl, toluene, ethyl benzene, o-, m-, p-xylene, formaldehyde, acetaldehyde, acetone, propenal, glyoxal.The present contribution describes our efforts to study the composition of vapors over the liquids for electronic cigarettes containing no flavors by means of IR-spectroscopy. The temperature range was 20 to 400 °C, and flow of air and argon was used. The electronic cigarette liquid was found to emit aqueous vapor, carbon dioxide, propylene glycol and glycerol mostly. Propenal was also detected in vapors in argon atmosphere at temperature of ~350 °C. No other compounds were found in neither liquid phase by 1H, 13C NMR spectroscopy after heating to 150 oC or vapors at temperature lower than 250 °C.Forcitation:Gamov G.A., Smirnov N.N., Aleksandriiskii V.V., Sharnin V.A. Thermal decomposition of electronic cigarette liquid. Ir study. Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol. 2017. V. 60. N2. P. 7-12.

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Will chronic e-cigarette use cause lung disease?

Cited by 99 publications

References 160 publications

The association between environmental tobacco smoke exposure and childhood respiratory disease: a review

The association between environmental tobacco smoke exposure and childhood respiratory disease: a review

Electronic Cigarette Use and Respiratory Symptoms in Adolescents

Thermal Decomposition of Electronic Cigarette Liquid. Ir Study

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