Will cancer cells be defeated by sodium bicarbonate?

Zhang, Hongtao

doi:10.1007/s11427-016-0373-3

Cited by 7 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, targeting the mechanisms by which cancer cells generate and survive in acidic microenvironments represents a possible strategy for limiting cancer metastasis. Some studies have even discussed injection of bicarbonate solution into the cancerous mass, or ingestion of sodium bicarbonate, to alkalinize the tumor environment, thereby reducing local acidosis and inhibiting metastasis ( 127 , 128 ).…”

Section: Cancermentioning

confidence: 99%

The H⁺-ATPase (V-ATPase): from proton pump to signaling complex in health and disease

Eaton

Merkulova

Brown

2021

American Journal of Physiology-Cell Physiology

View full text Add to dashboard Cite

A primary function of the H+-ATPase (or V-ATPase) is to create an electrochemical proton gradient across eukaryotic cell membranes, which energizes fundamental cellular processes. Its activity notably allows for the acidification of intracellular vesicles and organelles, which is necessary for many essential cell biological events to occur. In addition, many specialized cell types in various organ systems such as the kidney, bone, male reproductive tract, inner ear, olfactory mucosa, and more, use plasma membrane V-ATPases to perform specific activities that depend on extracellular acidification. However, it is increasingly apparent that V-ATPases are central players in many normal and pathophysiological processes that directly influence human health in many different, and sometimes unexpected ways. These include cancer, neurodegenerative diseases, diabetes, and sensory perception, as well as energy and nutrient sensing functions within cells. This review first covers the well-established role of the V-ATPase as a transmembrane proton pump in the plasma membrane and intracellular vesicles, and outlines factors contributing to its physiological regulation in different cell types. This is followed by a discussion of the more recently emerging unconventional roles for the V-ATPase, such as its role as a protein interaction hub involved in cell signaling, and the (patho)physiological implications of these interactions. Finally, the central importance of endosomal acidification and V-ATPase activity on viral infection will be discussed in the context of the current COVID-19 pandemic.

show abstract

Section: Cancermentioning

confidence: 99%

The H⁺-ATPase (V-ATPase): from proton pump to signaling complex in health and disease

Eaton

Merkulova

Brown

2021

American Journal of Physiology-Cell Physiology

View full text Add to dashboard Cite

show abstract

“…Drugs that decrease the cytoplasmatic utilization of glucose include 2-deoxyglucose, lonidamine, 3-bromopyruvate, imatinib, oxythiamine and hydroxycitrate, as well as other drugs that restore mitochondrial function, like alpha-lipoic acid [ 338 , 339 ]. Moreover, glycolysis has been reported to be paradoxically inhibited by the administration of buffering agents like sodium bicarbonate or potassium citrate [ 340 , 341 ].…”

Section: Towards a H + -Related Concerted Utilimentioning

confidence: 99%

Towards an Integral Therapeutic Protocol for Breast Cancer Based upon the New H+-Centered Anticancer Paradigm of the Late Post-Warburg Era

Harguindey¹,

Alfarouk

Orozco³

et al. 2020

IJMS

View full text Add to dashboard Cite

A brand new approach to the understanding of breast cancer (BC) is urgently needed. In this contribution, the etiology, pathogenesis, and treatment of this disease is approached from the new pH-centric anticancer paradigm. Only this unitarian perspective, based upon the hydrogen ion (H+) dynamics of cancer, allows for the understanding and integration of the many dualisms, confusions, and paradoxes of the disease. The new H+-related, wide-ranging model can embrace, from a unique perspective, the many aspects of the disease and, at the same time, therapeutically interfere with most, if not all, of the hallmarks of cancer known to date. The pH-related armamentarium available for the treatment of BC reviewed here may be beneficial for all types and stages of the disease. In this vein, we have attempted a megasynthesis of traditional and new knowledge in the different areas of breast cancer research and treatment based upon the wide-ranging approach afforded by the hydrogen ion dynamics of cancer. The concerted utilization of the pH-related drugs that are available nowadays for the treatment of breast cancer is advanced.

show abstract

“…Drugs that decrease the cytoplasmatic utilization of glucose include 2 -Deoxyglucose, Lonidamine, 3-Bromopyruvate, Imatinib, Oxythiamine and Hydroxycitrate, as well as other drugs that restore mitochondrial function, like alpha-lipoic acid [329,330]. Also, glycolysis has been reported to be paradoxically inhibited by the administration of buffering agents like Sodium Bicarbonate or Potassium Citrate [331,332].…”

Section: Antiestrogensmentioning

confidence: 99%

Towards An Integral Therapeutic Protocol for Breast Cancer based upon the New H+-Centered Anticancer Paradigm of the Late Post-Warburg Era

Harguindey¹,

Alfarouk

Orozco³

et al. 2020

Preprint

View full text Add to dashboard Cite

A brand-new approach to the understanding of breast cancer (BC) is urgently needed. In this contribution, the etiology, pathogenesis, and treatment of this disease is approached from the new pH-centric anticancer paradigm. Only this Unitarian perspective based upon that the hydrogen ion (H+) dynamics of cancer, allows understanding and integrating the many dualisms, confusions, and paradoxes of the disease. The new H+-related wide range model can embrace under a unique frame of mind the many aspects of the disease and at the same time therapeutically interfere with most, if not with all, the hallmarks of cancer known to date. The pH-related armamentarium available for the treatment of BC here reviewed may be beneficial for all types and stages of the disease. In this vein, we have attempted a mega synthesis of traditional and new knowledge in the different areas of breast cancer research and treatment based upon the wide range approach afforded by the hydrogen ion dynamics of cancer. The concerted utilization of a pH-related drugs nowadays available for the treatment of breast cancer is advanced.

show abstract

Will cancer cells be defeated by sodium bicarbonate?

Cited by 7 publications

References 9 publications

The H⁺-ATPase (V-ATPase): from proton pump to signaling complex in health and disease

The H⁺-ATPase (V-ATPase): from proton pump to signaling complex in health and disease

Towards an Integral Therapeutic Protocol for Breast Cancer Based upon the New H+-Centered Anticancer Paradigm of the Late Post-Warburg Era

Towards An Integral Therapeutic Protocol for Breast Cancer based upon the New H+-Centered Anticancer Paradigm of the Late Post-Warburg Era

Contact Info

Product

Resources

About

Will cancer cells be defeated by sodium bicarbonate?

Cited by 7 publications

References 9 publications

The H+-ATPase (V-ATPase): from proton pump to signaling complex in health and disease

The H+-ATPase (V-ATPase): from proton pump to signaling complex in health and disease

Towards an Integral Therapeutic Protocol for Breast Cancer Based upon the New H+-Centered Anticancer Paradigm of the Late Post-Warburg Era

Towards An Integral Therapeutic Protocol for Breast Cancer based upon the New H+-Centered Anticancer Paradigm of the Late Post-Warburg Era

Contact Info

Product

Resources

About

The H⁺-ATPase (V-ATPase): from proton pump to signaling complex in health and disease

The H⁺-ATPase (V-ATPase): from proton pump to signaling complex in health and disease