Will a Healthy Lifestyle Help Prevent Alzheimer's Disease?

Pope, Sandra K.; Shue, Valorie M.; Beck, Cornelia

doi:10.1146/annurev.publhealth.24.100901.141015

Cited by 111 publications

(68 citation statements)

References 94 publications

(85 reference statements)

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“…Finally, aging research on the protective role of exercise on cognitive decline and impairment is rapidly gaining momentum (6,31,44,75,97). The transfer of evidence to the context of driving would be speculative at present, but several plausible mechanisms may explain how inactivity results in cognitive impairment: Exercise may improve cerebral blood flow and neuronal growth and positively affect other risk factors for cognitive decline such as stress hormones, lipids, insulin levels, and immune function.…”

Section: Taylor Dornmentioning

confidence: 99%

STRESS, FATIGUE, HEALTH, AND RISK OF ROAD TRAFFIC ACCIDENTS AMONG PROFESSIONAL DRIVERS: The Contribution of Physical Inactivity

Taylor

Dorn²

2006

Annu. Rev. Public Health

230

139

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Key Words driver, occupational health, exercise, health promotion, stress management ■ Abstract Strategies to achieve ambitious targets for reducing road accidents (34) have largely focused on engineering and technological advancements, the modification of occupational demands, and, to a lesser extent, human factors. These factors include stress and psychological states; sleep, fatigue, and alertness; and health status. Physical activity appears to influence all these human factors but has not previously been systematically considered as a direct or indirect risk factor for driver accidents. This chapter provides an overview, within an evidence-based framework, of the impact each of these human factors has on driver performance and risk of at-work road traffic accidents and then examines how physical (in)activity may moderate and mediate these relationships. Finally, we consider practical implications for work site interventions. The review aims to offer an evidence base for the deployment of resources to promote physical activity, manage stress, facilitate sleep, reduce fatigue, and enhance alertness to improve physical and psychological health among professional drivers.

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Section: Taylor Dornmentioning

confidence: 99%

STRESS, FATIGUE, HEALTH, AND RISK OF ROAD TRAFFIC ACCIDENTS AMONG PROFESSIONAL DRIVERS: The Contribution of Physical Inactivity

Taylor

Dorn²

2006

Annu. Rev. Public Health

230

139

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“…Current therapeutics temporarily ameliorate the symptoms of AD, but few affect the underlying disease mechanism (Selkoe and Schenk, 2003). A number of epidemiological studies, however, suggest that simple lifestyle changes may be sufficient to slow the onset and progression of AD (Pope et al, 2003). A recent retrospective case control study (Friedland et al, 2001), for example, demonstrated that patients with AD were less active (both intellectually and physically) in midlife and that inactivity was associated with a 250% increased risk of developing AD.…”

Section: Introductionmentioning

confidence: 99%

Voluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer's Disease

Adlard¹,

Perreau²,

Pop³

et al. 2005

J. Neurosci.

695

454

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Alzheimer's disease (AD) is a progressive neurodegenerative disorder for which there are few therapeutics that affect the underlying disease mechanism. Recent epidemiological studies, however, suggest that lifestyle changes may slow the onset/progression of AD. Here we have used TgCRND8 mice to examine directly the interaction between exercise and the AD cascade. Five months of voluntary exercise resulted in a decrease in extracellular amyloid-␤ (A␤) plaques in the frontal cortex (38%; p ϭ 0.018), the cortex at the level of the hippocampus (53%; p ϭ 0.0003), and the hippocampus (40%; p ϭ 0.06). This was associated with decreased cortical A␤1-40 (35%; p ϭ 0.005) and A␤1-42 (22%; p ϭ 0.04) (ELISA). The mechanism appears to be mediated by a change in the processing of the amyloid precursor protein (APP) after short-term exercise, because 1 month of activity decreased the proteolytic fragments of APP [for ␣-Cterminal fragment (␣-CTF), 54% and p ϭ 0.04; for ␤-CTF, 35% and p ϭ 0.03]. This effect was independent of mRNA/protein changes in neprilysin and insulin-degrading enzyme and, instead, may involve neuronal metabolism changes that are known to affect APP processing and to be regulated by exercise. Long-term exercise also enhanced the rate of learning of TgCRND8 animals in the Morris water maze, with significant ( p Ͻ 0.02) reductions in escape latencies over the first 3 (of 6) trial days. In support of existing epidemiological studies, this investigation demonstrates that exercise is a simple behavioral intervention sufficient to inhibit the normal progression of AD-like neuropathology in the TgCRND8 mouse model.

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“…The positive aspect of these activities such as physical exercises, cognitive training or the Mediterranean is also the fact that people can continue in them even in the older age. Moreover, it has been proved that following a healthy lifestyle might directly protect against the development of AD and other disease connected with AD, for instance, vascular disease and diabetes (Pope, Shue, & Beck, 2003).…”

Section: Resultsmentioning

confidence: 99%

Alternative Approaches in the Prevention of Alzheimer’s Disease

Klímová

2016

The European Proceedings of Social and Behavioural Sciences

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Alzheimer's disease (AD) is currently the most common incurable forms of dementia. The number of people affected by this disease is expected to grow rapidly in the next decades due to the present demographic changes. Since the pharmacological treatment of AD is quite costly, researchers try to look for alternative treatments for patients suffering from AD. The purpose of this article is to explore the non-pharmacological preventive intervention strategies which can help healthy elderly individuals to delay the development of AD and in this way enable them to stay independent on the assistance of other people. Firstly, a method of literature review analyzing the data contained in the world's prestigious scientific databases: PubMed, Web of Science, Springer, and Scopus, in the period of 1990 -2015 is used. Secondly, a method of comparison of different research studies examining preventive, non-invasive, intervention strategies in lowering the risk of cognitive decline is applied.

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Will a Healthy Lifestyle Help Prevent Alzheimer's Disease?

Cited by 111 publications

References 94 publications

STRESS, FATIGUE, HEALTH, AND RISK OF ROAD TRAFFIC ACCIDENTS AMONG PROFESSIONAL DRIVERS: The Contribution of Physical Inactivity

STRESS, FATIGUE, HEALTH, AND RISK OF ROAD TRAFFIC ACCIDENTS AMONG PROFESSIONAL DRIVERS: The Contribution of Physical Inactivity

Voluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer's Disease

Alternative Approaches in the Prevention of Alzheimer’s Disease

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