A B S T R A C TRecordings have been made from the soma of a cockroach common inhibitory motoneurone. Locally applied dopamine, octopamine or noradrenaline all depolarised the neurone and produced a modest increase in membrane conductance. Under voltage-clamp, currents evoked by these amines showed considerable voltage dependence. The current-voltage relationships for dopamine and octopamine responses were similar, but differed from that for noradrenaline. The unusual voltage-dependent characteristics of these responses suggest that these compounds may serve a modulatory junction in the insect C N S .The eJects of a range of pharmacological antagonists indicate that dopamine acts upon a class of receptors distinct from those mediating responses to octopamine, noradrenaline and acetylcholine (ACh). Dopamine currents were abolished by SCH 23390 or cis-(Z)-flupenthixol, which did not depress responses to the other agonists. Octopamine and noradrenaline currents were selectively blocked by metoclopramide and ergometrine respectively, while a-bungarotoxin and gallamine preferentially suppressed ACh responses.At the present time the ionic basis of dopamine responses is unclear.Dopamine-evoked currents were totally abolished by application of Cd2 ' or verapamil or when the preparation was bathed in Ca2+-jiree external solutions. Changes in the external concentrations of Na', K' or C1-, however, also had some effect upon dopamine currents.