Wild Sambucus nigra L. from north-east edge of the species range: A valuable germplasm with inhibitory capacity against SARS-CoV2 S-protein RBD and hACE2 binding in vitro

Boroduske, Anete; Jēkabsons, Kaspars; Riekstiņa, Una; Muceniece, Ruta; Rostoks, Nils; Nakurte, Ilva

doi:10.1016/j.indcrop.2021.113438

Cited by 28 publications

(21 citation statements)

References 54 publications

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“…The wild elderberries extract showed a higher inhibitory capacity than the “Haschberg” culture elderberries extract which was taken as a reference. This study validates the requirement for bioprospecting the wild germplasm of S. nigra and opens directions for further research into new industrial anti-SARS-CoV2 applications of S. nigra [ 77 ].…”

Section: Introductionsupporting

confidence: 70%

“…In a study published in March 2021, Boroduske et al [ 77 ] presents the results obtained with some species from the northeastern part of Europe: a germplasm with inhibitory capacity against the S protein (spike) SARS-CoV2, the binding of RBD (receptor-binding domain) and hACE2 (angiotensin converting enzyme 2) in vitro. Thus, the best performing S. nigra extracts were selected for the evaluation of previously undeclared biological activity-inhibitory capacity against SARS-CoV2.…”

Section: Introductionmentioning

confidence: 99%

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Elderberries—A Source of Bioactive Compounds with Antiviral Action

Mocanu

Amariei

2022

Plants

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In the current context, when more and more unknown pathogens appear, healthy eating and supplementing it with natural products play an increasingly important role in maintaining the health of the body. The European black elder (Sambucus nigra), found in abundance in the spontaneous flora, can provide us, as a raw material, elderberries, which have been known for thousands of years as having nutritional and healing properties. The phytotherapeutic principles found in elderberry fruits give them antiviral, antibacterial and antidiabetic properties, antitumor potential, antioxidant, antidepressant and immune boosting properties, as well as a certain impacts on obesity and metabolic dysfunctions. Polyphenols and lectins give elderberry fruits the ability to inhibit coronaviruses, which is a topic of great interest in our times. This article summarizes the existing data regarding the chemical composition, active principles and biopharmaceutical properties of elderberries, as well as their use.

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Section: Introductionsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Elderberries—A Source of Bioactive Compounds with Antiviral Action

Mocanu

Amariei

2022

Plants

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“…Recently, the immunomodulatory properties of elderberry fruit phenolic compounds have been proposed for research on COVID-19 treatment [14,15]. Although such research on S. nigra is still in its infancy, recent studies to that end are already yielding promising results; for example, evidence has been found during viral entry in vitro on inhibition of binding of the S1 protein receptor of SARS-CoV2 to an enzyme related to the immune system (ACE2) by flower and fruit extracts of both wild-growing and cultivated genotypes of S. nigra, with wild germplasm presenting higher inhibitory capacity [16].…”

Section: Introductionmentioning

confidence: 99%

Molecular Authentication, Propagation Trials and Field Establishment of Greek Native Genotypes of Sambucus nigra L. (Caprifoliaceae): Setting the Basis for Domestication and Sustainable Utilization

et al. 2022

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In the context of sustainable utilisation of valuable but neglected plant resources, a multifaceted study is presented herein for Greek native genotypes of elderberry (Sambucus nigra L., Caprifoliaceae), a species with an appreciated pharmaceutical and nutritional value. At the first phase, fresh plant materials (leaves, softwood cuttings) were collected from nine geographically separated genotypes originating from wild-growing Greek native germplasm of S. nigra. The leaf samples were genetically authenticated using DNA barcoding (ITS2). The next phase included the development of an asexual propagation protocol via cuttings which included screening of the collected genotypes in terms of propagation success, and further experimentation over a two-year period on a prioritised genotype. The propagation results highlighted the importance of external application of indole-3-butyric acid (IBA) rooting hormone at levels of 2000–4000 ppm, which consistently presented high rooting rates (100%) of summer softwood, leafy cuttings of apical or sub-apical type. At the same time, rooting quality in terms of root number and length as well as early plant growth after rooting, were improved by external hormone application resulting in high rates of plant survival. This study reports first-time data on multifaceted assessment of Greek native S. nigra genotypes on molecular authentication and asexual propagation, thus ultimately setting the basis for domestication and sustainable utilization of this species.

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“…(Tito et al, 2021 ). Similarly, elderberry extracts might interfere with the spike receptor interaction (Boroduske et al, 2021 ) and green tea catechins have been shown to destroy the virion structure and its main catechin epigallocatechin gallate (EGCG) aggregates virus particles to prevent their interaction with target cells (Nishimura, Okamoto, Dapat, Katsumi, & Oshitani, 2021 ; Xu, Xu, & Zheng, 2017 ). Specifically for SARS‐CoV‐2, EGCG has been shown to inhibit the activity of the 3CL protease, prevent attachment to ACE2 and directly inactivate viral particles (Jang et al, 2020 ; Liu et al, 2021 ; Ohgitani et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Antiviral activity of plant juices and green tea against SARS‐CoV‐2 and influenza virus

Eggers

Jungke

Wolkinger

et al. 2022

Phytotherapy Research

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Respiratory viruses pose a significant threat to global health. They initially infect the naso‐ and oropharyngeal regions, where they amplify, cause symptoms, and may also be transmitted to new hosts. Preventing initial infection or reducing viral loads upon infection might soothe symptoms, prevent dissemination into the lower airways, or transmission to the next individual. Several natural products have well‐described direct antiviral activity or may ameliorate symptoms of respiratory infections. We thus analyzed the potential of plant‐derived products to inactivate respiratory viral pathogens and determined the antiviral activity of black chokeberry (Aronia melanocarpae [Michx.] Elliott), elderberry (Sambucus nigra L.), and pomegranate (Punica granatum L.) juice, as well as green tea (Camellia sinensis [L.] Kuntze) on the infectivity of the surrogate‐modified vaccinia virus Ankara, and the respiratory viruses severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), influenza A virus (IAV), and adenovirus Type 5. Black chokeberry and pomegranate juice, and green tea reduced SARS‐CoV‐2 and IAV titers by ≥80% or ≥99%. This suggests that oral rinsing with these products may reduce viral loads in the oral cavity which might prevent viral transmission.

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Wild Sambucus nigra L. from north-east edge of the species range: A valuable germplasm with inhibitory capacity against SARS-CoV2 S-protein RBD and hACE2 binding in vitro

Abstract: Graphical abstract

Cited by 28 publications

References 54 publications

Elderberries—A Source of Bioactive Compounds with Antiviral Action

Elderberries—A Source of Bioactive Compounds with Antiviral Action

Molecular Authentication, Propagation Trials and Field Establishment of Greek Native Genotypes of Sambucus nigra L. (Caprifoliaceae): Setting the Basis for Domestication and Sustainable Utilization

Antiviral activity of plant juices and green tea against SARS‐CoV‐2 and influenza virus

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