Wild Passiflora (Passiflora spp.) seed oils and their nanoemulsions induce proliferation in HaCaT keratinocytes cells

Souza, Myla Lôbo de; Dourado, Douglas; Lôbo, Ivon Pinheiro; Pires, Vinícius C.; Rebouças, Juliana de Souza; Costa, Ana Maria; Fernandes, Caio P.; Tavares, Natália Machado; Pereira, Neila de Paula; Formiga, Fabio Rocha

doi:10.1016/j.jddst.2021.102803

Cited by 5 publications

(5 citation statements)

References 55 publications

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“…Where SLN is formed by solid lipids at room and body temperature, and NLC, the second generation of lipid nanoparticles, is composed of a liquid lipid in addition to the solid lipid, reducing the crystallinity of the particle matrix and increasing the stability time of the system with the incorporation of the active [ 73 ]. Another type of lipid nanosystem is the nanoemulsion, characterized as the colloidal dispersion of two immiscible liquids, where one of them composes the dispersed internal phase and the other the external phase, forming droplets of average diameter on the nanometric scale [ 74 , 75 ]. These systems are widely used for drug delivery since the existence of polar and non-polar phases at the interface of the system promotes a high ability to incorporate molecules with different characteristics in terms of solubility [ 76 ].…”

Section: Nanocarriers: General Aspectsmentioning

confidence: 99%

From Benznidazole to New Drugs: Nanotechnology Contribution in Chagas Disease

Gomes,

Medeiros,

Alves Pereira

et al. 2023

IJMS

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Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma cruzi. Benznidazole and nifurtimox are the two approved drugs for their treatment, but both drugs present side effects and efficacy problems, especially in the chronic phase of this disease. Therefore, new molecules have been tested with promising results aiming for strategic targeting action against T. cruzi. Several studies involve in vitro screening, but a considerable number of in vivo studies describe drug bioavailability increment, drug stability, toxicity assessment, and mainly the efficacy of new drugs and formulations. In this context, new drug delivery systems, such as nanotechnology systems, have been developed for these purposes. Some nanocarriers are able to interact with the immune system of the vertebrate host, modulating the immune response to the elimination of pathogenic microorganisms. In this overview of nanotechnology-based delivery strategies for established and new antichagasic agents, different strategies, and limitations of a wide class of nanocarriers are explored, as new perspectives in the treatment and monitoring of Chagas disease.

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Section: Nanocarriers: General Aspectsmentioning

confidence: 99%

From Benznidazole to New Drugs: Nanotechnology Contribution in Chagas Disease

Gomes,

Medeiros,

Alves Pereira

et al. 2023

IJMS

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show abstract

“…On the other hand, dynamic light scattering (DLS) provides the hydrodynamic diameter, using mathematical models to generate the data displayed as particle size and to infer size distribution [22]. Based on this understanding, the two techniques have been used in combination to obtain a more robust measure [59].…”

Section: Organogel Nanoparticle Morphology Analysis By Transmission E...mentioning

confidence: 99%

“…The particle size and polydispersity index of SON and RSON were evaluated by dynamic light scattering (DLS) using a Zetasizer ® Nano (ZS90, Malvern-Panalytical, Malvern, UK) at 25 • C and a fixed angle of 90 • for 90 days [22,59]. Additionally, the zeta potential was measured during the same period using the electrophoretic mobility technique with the same equipment.…”

Section: Organogel Nanoparticles Size Distribution and Zeta Potentialmentioning

confidence: 99%

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Resveratrol-Loaded Attalea funifera Oil Organogel Nanoparticles: A Potential Nanocarrier against A375 Human Melanoma Cells

Dourado

Batista

Philadelpho

et al. 2023

IJMS

Self Cite

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This study aimed to evaluate Attalea funifera seed oil with or without resveratrol entrapped in organogel nanoparticles in vitro against A375 human melanoma tumor cells. Organogel nanoparticles with seed oil (SON) or with resveratrol entrapped in the seed oil (RSON) formed functional organogel nanoparticles that showed a particle size <100 nm, polydispersity index <0.3, negative zeta potential, and maintenance of electrical conductivity. The resveratrol entrapment efficiency in RSON was 99 ± 1%. The seed oil and SON showed no cytotoxicity against human non-tumor cells or tumor cells. Resveratrol at 50 μg/mL was cytotoxic for non-tumor cells, and was cytotoxic for tumor cells at 25 μg/mL. Resveratrol entrapped in RSON showed a decrease in cytotoxicity against non-tumor cells and cytotoxic against tumor cells at 50 μg/mL. Thus, SON is a potential new platform for the delivery of resveratrol with selective cytotoxic activity in the treatment of melanoma.

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“…For instance, a sun-protective makeup product containing P. edulis seed extract was successfully developed, demonstrating UVA and UVB protection [6]. Moreover, nanoemulsions formulated with different seed oils from wild Passiflora species (such as P. setacea, P. cincinnata, P. tenuifila, and P. alata) induced the proliferation of keratinocytes, indicating a healing effect and potential as natural materials in cosmeceutical applications [7]. The most important components in P. quadrangularis fruit extract are vitamin C and phenolic and flavonoid compounds possessing anti-oxidant properties.…”

Section: Introductionmentioning

confidence: 99%

Nanoemulsions Containing Passiflora quadrangularis L. Fruit Extracts for Cosmetic Application and Skin Efficacy Study

Yanasan,

Wangkananon,

Natakankitkul

et al. 2024

Cosmetics

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This study aimed to determine the anti-collagenase, anti-elastase, and anti-hyaluronidase activities of Passiflora quadrangularis fruit extracts (epicarp, mesocarp, endocarp, and seed), develop stable nanoemulsions, and evaluate the efficacy of the nanoemulsions containing extracts in human volunteers. The results indicated that the epicarp and seed extracts exhibited collagenase, elastase, and hyaluronidase inhibition effects. Gallic acid was identified in the extracts, with the highest concentration found in the endocarp extract (1449.35 mg gallic acid/g extract) followed by the seed extract (839.63 mg gallic acid/g extract). The endocarp and seed extracts demonstrated good stability at different temperatures. Consequently, these extracts were selected for incorporation into nanoemulsions due to their high yield, excellent anti-tyrosinase and anti-aging activity, and good stability, making them suitable for cosmetic products. The nanoemulsions were prepared using the ultrasonication method, resulting in a particle size of 133.1 ± 0.8 nm, a polydispersity index of 0.33 ± 0.03, and a zeta potential of −61.8 ± 0.6 mV, indicating good stability. The nano-serum containing extracts was non-irritating and safe for the skin. Skin evaluation among human volunteers after 60 days of application revealed improvements in skin hydration and reduction in wrinkles. In conclusion, nanoemulsions containing P. quadrangularis fruit extracts have the potential to be effective cosmetic products.

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Wild Passiflora (Passiflora spp.) seed oils and their nanoemulsions induce proliferation in HaCaT keratinocytes cells

Cited by 5 publications

References 55 publications

From Benznidazole to New Drugs: Nanotechnology Contribution in Chagas Disease

From Benznidazole to New Drugs: Nanotechnology Contribution in Chagas Disease

Resveratrol-Loaded Attalea funifera Oil Organogel Nanoparticles: A Potential Nanocarrier against A375 Human Melanoma Cells

Nanoemulsions Containing Passiflora quadrangularis L. Fruit Extracts for Cosmetic Application and Skin Efficacy Study

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