Wild and cultivated olive trees: Nutraceutical insights of extra virgin olive oils in cardiovascular and ocular diseases

Reyes-Goya, C.; Santana-Garrido, Á.; Espinosa-Martín, P.; Vázquez, C.M.; Mate, A.

doi:10.1016/j.bbadis.2023.166904

Cited by 4 publications

(2 citation statements)

References 183 publications

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“…The rising awareness about the valuable effects of prime nutrition, including functional foods, the pursuit for olives, and their subproducts, has notably increased in high-income countries with rapid expansion of olive-based products [ 5 , 6 ]. Olive oil is the main dietary fat in the Mediterranean diet, associated with a reduced incidence of cardiovascular diseases and some types of cancers [ 7 , 8 , 9 , 10 ]. The beneficial effects of olive oil are mainly attributed to its high content of monounsaturated fatty acids (MUFAs) and multifunctional bioactives including tocopherols, carotenoids, and phenolics [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Potential Therapeutic Properties of Olea europaea Leaves from Selected Cultivars Based on Their Mineral and Organic Profiles

de Oliveira,

Machado,

Chéu

et al. 2024

Pharmaceuticals

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Olive leaves are consumed as an extract or as a whole herbal powder with several potential therapeutic benefits attributed to polyphenols, tocopherol’s isomers, and flavonoids, among others. This study assessed the potential variance in the functional features presented by olive leaves from three different Portuguese cultivars—Cobrançosa, Madural, and Verdeal—randomly mix-cultivated in the geographical area of Vale de Salgueiros. Inorganic analysis determined their mineral profiles while an organic analysis measured their total phenolic and flavonoid content, and scanned their phenolic and tocopherol and fatty acid composition. The extracts’ biological activity was tested by determining their antimicrobial and antioxidant power as well as their ability to inhibit acetylcholinesterase, butyrylcholinesterase, MAO-A/B, and angiotensin-I-converting enzyme. The inorganic profiles showed them to be an inexpensive source able to address different mineral deficiencies. All cultivars appear to have potential for use as possible antioxidants and future alternative antibiotics against some multidrug-resistant microorganisms, with caution regarding the arsenic content in the Verdeal cultivar. Madural’s extract displayed properties to be considered a natural multitarget treatment for Alzheimer’s and Parkinson’s diseases, depression, and cardiometabolic and dual activity for blood pressure modulation. This work indicates that randomly cultivating different cultivars significantly modifies the leaves’ composition while keeping their multifaceted therapeutic value.

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Section: Introductionmentioning

confidence: 99%

Potential Therapeutic Properties of Olea europaea Leaves from Selected Cultivars Based on Their Mineral and Organic Profiles

de Oliveira,

Machado,

Chéu

et al. 2024

Pharmaceuticals

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“…sylvestris), also called Acebuche (ACE), deserves attention. ACE olive tree is one of the oldest trees worldwide [24] and the oil derived from it contains tocopherols (e.g., vitamin E), sterols, triterpene acids and secoiridoid compounds in higher quantity compared to the classic extra virgin olive oil [25]. Moreover, it was recently demonstrated that ACE oil-enriched diet exerts anti-inflammatory, antioxidant and retinoprotective effects in a mouse model of arterial hypertension [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

The Anti-Inflammatory and Antioxidant Properties of Acebuche Oil Exert a Retinoprotective Effect in a Murine Model of High-Tension Glaucoma

Lucchesi,

Marracci,

Amato

et al. 2024

Nutrients

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Glaucoma is characterized by cupping of the optic disc, apoptotic degeneration of retinal ganglion cells (RGCs) and their axons, and thinning of the retinal nerve fiber layer, with patchy loss of vision. Elevated intraocular pressure (IOP) is a major risk factor for hypertensive glaucoma and the only modifiable one. There is a need to find novel compounds that counteract other risk factors contributing to RGC degeneration. The oil derived from the wild olive tree (Olea europaea var. sylvestris), also called Acebuche (ACE), shows powerful anti-inflammatory, antioxidant and retinoprotective effects. We evaluated whether ACE oil could counteract glaucoma-related detrimental effects. To this aim, we fed mice either a regular or an ACE oil-enriched diet and then induced IOP elevation through intraocular injection of methylcellulose. An ACE oil-enriched diet suppressed glaucoma-dependent retinal glia reactivity and inflammation. The redox status of the glaucomatous retinas was restored to a control-like situation, and ischemia was alleviated by an ACE oil-enriched diet. Notably, retinal apoptosis was suppressed in the glaucomatous animals fed ACE oil. Furthermore, as shown by electroretinogram analyses, RGC electrophysiological functions were almost completely preserved by the ACE oil-enriched diet. These ameliorative effects were IOP-independent and might depend on ACE oil’s peculiar composition. Although additional studies are needed, nutritional supplementation with ACE oil might represent an adjuvant in the management of glaucoma.

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Turn to the wild: A comprehensive review on the chemical composition of wild olive oil

Pavlidis,

Kafentzi,

Rekoumi

et al. 2024

Food Research International

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Wild and cultivated olive trees: Nutraceutical insights of extra virgin olive oils in cardiovascular and ocular diseases

Cited by 4 publications

References 183 publications

Potential Therapeutic Properties of Olea europaea Leaves from Selected Cultivars Based on Their Mineral and Organic Profiles

Potential Therapeutic Properties of Olea europaea Leaves from Selected Cultivars Based on Their Mineral and Organic Profiles

The Anti-Inflammatory and Antioxidant Properties of Acebuche Oil Exert a Retinoprotective Effect in a Murine Model of High-Tension Glaucoma

Turn to the wild: A comprehensive review on the chemical composition of wild olive oil

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