Widespread neocortical abnormalities in temporal lobe epilepsy with and without mesial sclerosis

Mueller, Susanne; Laxer, Kenneth D.; Barakos, Jerome; Cheong, Ian; Garcia, Paul A.; Weiner, Michael W.

doi:10.1016/j.neuroimage.2009.02.020

Cited by 122 publications

(154 citation statements)

References 53 publications

Supporting

Mentioning

128

Contrasting

Unclassified

Order By: Relevance

“…Similar findings have also been seen with cortical thickness (Mueller et al, 2009), with more widespread neocortical thinning seen in non-MTS patients. The hippocampal pathology reported in this patient group supports the finding that non-MTS patients have fewer abnormalities in mesial structures with these patients only having minor degrees of gliosis reported.…”

Section: Discussionsupporting

confidence: 81%

Quantitative relaxometry and diffusion MRI for lateralization in MTS and non-MTS temporal lobe epilepsy

et al. 2014

View full text Add to dashboard Cite

We developed novel methodology for investigating the use of quantitative relaxometry (T1, T2) and diffusion tensor imaging (DTI) for lateralization in temporal lobe epilepsy. Patients with mesial temporal sclerosis confirmed by pathology (N=8) and non-MTS unilateral temporal lobe epilepsy (N=6) were compared against healthy controls (N=19) using voxel-based analysis restricted to the anterior temporal lobes, and laterality indices for each MRI metric (T1, T2, fractional anisotropy (FA), mean diffusivity, axial and radial diffusivity) were computed based on the proportion of significant voxels on each side. The diffusivity metrics were the most lateralizing MRI metrics in MTS and non-MTS subsets, with significant differences also seen with FA, T1 and T2. Patient-specific multi-modal laterality indices were also computed and were shown to clearly separate the left-onset and right-onset patients. Marked differences between leftonset and right-onset patients were also observed, with left-onset patients exhibiting stronger laterality indices. Finally, neocortical abnormalities were found to be more common in the non-MTS patients. These preliminary results on a small sample size support the further investigation of quantitative MRI and multi-modal image analysis in clinical determination of seizure onset.The presence of more neocortical abnormalities in the non-MTS group suggests a role in seizure onset or propagation and motivates the investigation of more sensitive histopathological analysis to detect and delineate potentially subtle neocortical pathology.

show abstract

Section: Discussionsupporting

confidence: 81%

Quantitative relaxometry and diffusion MRI for lateralization in MTS and non-MTS temporal lobe epilepsy

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Reduced cortical thickness in epilepsy is not specific for RE and has been demonstrated before in both adult and paediatric patients (Mueller et al, 2009;Widjaja et al, 2011). In this study, we found reduced cortical thickness not only in the rolandic cortex, but also in the supramarginal and superior temporal gyrus of the left hemisphere.…”

Section: Reduced Cortical Thicknesssupporting

confidence: 71%

“…In recent years, quantitative techniques to study cortical thickness have been developed (Fischl and Dale, 2000;Kim et al, 2005). These techniques allow local analysis of the entire cortex and are less influenced by inter-individual gyral variations than traditional voxel-based whole-brain methods, such as voxelbased-morphology (VBM) (Mueller et al, 2009). In a group of children with frontal lobe epilepsy, cortical thickness analysis has been successfully applied; in a study of Widjaja et al (Widjaja et al, 2011), regions of thinner cortex were found both within and beyond the frontal lobe.…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

“…In a group of children with frontal lobe epilepsy, cortical thickness analysis has been successfully applied; in a study of Widjaja et al (Widjaja et al, 2011), regions of thinner cortex were found both within and beyond the frontal lobe. Also in other types of epilepsy, such as temporal lobe epilepsy in adults, reduced cortical thickness has been reported beyond the lobe of the primary seizure focus (Mueller et al, 2009).…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

See 1 more Smart Citation

Early onset of cortical thinning in children with Rolandic epilepsy

Overvliet

Besseling

Jansen

et al. 2013

Journal of the Neurological Sciences

View full text Add to dashboard Cite

Document VersionPublisher's PDF, also known as Version of Record (includes final page, issue and volume numbers) Please check the document version of this publication:• A submitted manuscript is the author's version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website.• The final author version and the galley proof are versions of the publication after peer review.• The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Introduction: Rolandic epilepsy, a childhood epilepsy associated with language impairments, was investigated for language-related cortical abnormalities. Methods: Twenty-four children with rolandic epilepsy and 24 controls (age 8-14 years) were recruited and underwent the Clinical Evaluation of Language Fundamentals test. Structural MRI was performed at 3 T (voxel size 1 × 1 × 1 mm 3 ) for fully automated quantitative assessment of cortical thickness. Regression analysis was used to test for differences between patients and controls and to assess the effect of age and language indices on cortical thickness. Results: For patients the core language score (mean ± SD: 92 ± 18) was lower than for controls (106 ± 11, p = 0.0026) and below the norm of 100 ± 15 (p = 0.047). Patients showed specific impairments in receptive language index (87 ± 19, p = 0.002) and language content index (87 ± 18, p = 0.0016). Cortical thickness was reduced in patients (p b 0.05, multiple-comparisons corrected) in left perisylvian regions. Furthermore, extensive cortical thinning with age was found in predominantly left-lateralized frontal, centro-parietal and temporal regions. No associations were found between cortical thickness and language indices in the regions of aberrant cortex. Conclusion: The cortical abnormalities described represent subtle but significant pathomorphology in this critical phase of brain development (8-14 years) and suggest that rolandic epilepsy should not be considered merely a...

show abstract

“…[1][2][3][4][5][6][7] Volumetric abnormalities have been reported in neuronal regions involved in the generation and propagation of seizures, including the hippocampus, [8][9][10][11] amygdala, 12 entorhinal cortex, 13 thalamus, 14 and also extratemporal regions 15,16 in patients with chronic temporal lobe epilepsy. Children with idiopathic generalized epilepsies have also shown distributed patterns of abnormality affecting the thalamus and frontal lobe.…”

mentioning

confidence: 99%