Widespread Morphometric Abnormalities in Major Depression

Fu, Cynthia H.Y.; Fan, Yong; Davatzikos, Christos

doi:10.1016/j.nic.2019.09.008

Cited by 6 publications

(1 citation statement)

References 99 publications

(122 reference statements)

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“…In turn, depression may increase risk for SCC via changes in brain structure and function, including in the prefrontal cortex, hippocampus, and amygdala. These regions are all involved in cognition, executive function (such as planning, decision-making, and reasoning), and emotion processing [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Food insecurity and subjective cognitive complaints among adults aged ≥ 65 years from low- and middle-income countries

Smith,

López Sánchez,

Shin

et al. 2023

Eur J Nutr

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Purpose To date, no study has investigated the association between food insecurity and subjective cognitive complaints (SCC). Thus, the aims of the present study were to examine this association among older adults in low- and middle-income countries (LMICs), and to identify the potential mediators in this association, given the importance of SCC in dementia risk among older people, and the projected particularly large increase in dementia in this setting. Methods Cross-sectional, community-based, nationally representative data from the World Health Organization (WHO) Study on global AGEing and Adult Health (SAGE) collected between 2007 and 2010 were analyzed. Two questions on subjective memory and learning complaints in the past 30 days were used to create a SCC scale ranging from 0 (No SCC) to 100 (worse SCC). Past 12 month food insecurity was assessed with two questions on frequency of eating less and hunger due to lack of food. Multivariable linear regression and mediation (Karlson–Holm–Breen method) analyses were conducted to assess associations. Results Data on 14,585 individuals aged ≥ 65 years [mean (SD) age 72.6 (11.5) years; 55.0% females] were analyzed. Severe food insecurity (vs. no food insecurity) was associated with 9.16 (95% CI = 6.95–11.37) points higher mean SCC score. Sleep/energy (mediated% 37.9%; P < 0.001), perceived stress (37.2%; P = 0.001), and depression (13.7%; P = 0.008) partially explained the association between severe food insecurity and SCC. Conclusion Food insecurity was associated with SCC among older adults in LMICs. Future studies should assess whether addressing food insecurity among older adults in LMICs can improve cognitive health.

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Section: Discussionmentioning

confidence: 99%