Widespread keratosis pilaris–like eruption in an immunocompromised child

Frigerio, Alice; Toptan, Tuna; Chang, Yuan; Abbott, Jeff; Cipriano, Sarah D.; Bowen, Anneli R.

doi:10.1016/j.jdcr.2019.02.001

Cited by 6 publications

(10 citation statements)

References 10 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All patients presented with predominately centrofacial folliculocentric papules with keratinaceous spines. Twelve of the 19 cases demonstrated generalized involvement including the trunk and extremities 2,4,7,9‐15,18 . Lateral eyebrow alopecia and less commonly eyelash alopecia were reported as well 2,7,8,11,12,17,20 .…”

Section: Resultsmentioning

confidence: 98%

“…Patient ages ranged from 20 months to 15 years. Lymphoblastic leukemia was the most common underlying diagnosis, reported in seven patients 7‐13 . Renal transplant was the second most common, reported in five patients 4,14‐16 .…”

Section: Resultsmentioning

confidence: 99%

“…Lymphoblastic leukemia was the most common underlying diagnosis, reported in seven patients. [7][8][9][10][11][12][13] Renal transplant was the second most common, reported in five patients. 4,[14][15][16] Other underlying diagnoses included heart transplant, colon transplant, lung transplant, and multiorgan transplant.…”

Section: Re Sultsmentioning

confidence: 99%

See 2 more Smart Citations

Pediatric trichodysplasia spinulosa: A report of 2 cases and review of the literature

Rusk

Crute

Goebel

et al. 2020

Pediatric Dermatology

View full text Add to dashboard Cite

Trichodysplasia spinulosa is a rare disorder caused by the ubiquitous trichodysplasia spinulosa-associated polyomavirus (TSPyV) and characterized clinically by predominately centrofacial, but often generalized, folliculocentric papules with protuberant keratinaceous spines. Although seroprevalence reaches up to 70% in adult populations, TSPyV causes clinical manifestations in a small percentage of patients who are immunosuppressed. Diagnosis can be made using typical clinical and histologic features, SV40T antibody immunostaining, and PCR of various tissues including the keratinaceous spine, skin, serum, urine, and CSF. Various topical and systemic medications have demonstrated variable success. Decreasing or discontinuing immunosuppression has also been shown to improve or alleviate clinical manifestations.

show abstract

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Pediatric trichodysplasia spinulosa: A report of 2 cases and review of the literature

Rusk

Crute

Goebel

et al. 2020

Pediatric Dermatology

View full text Add to dashboard Cite

show abstract

“…However, other recent diagnosis methods—such as immunohistochemistry, scanning electron microscopy, and PCR—have been used to confirm the viral etiology. 11 Clinically, TS is characterized by an eruption of follicular flesh-colored or pink papules frequently featuring central keratotic spicules. It mainly affects the central face, ears, and, in a lesser proportion, the trunk and the extremities.…”

Section: Discussionmentioning

confidence: 99%

Trichodysplasia spinulosa in a renal transplant patient: A case report of successful treatment

Pennou

Javidi

Lecours

et al. 2020

SAGE Open Medical Case Reports

View full text Add to dashboard Cite

Trichodysplasia spinulosa is a rare cutaneous disease caused by the trichodysplasia spinulosa–associated polyomavirus. It occurs more frequently in immunocompromised patients, particularly in solid organ transplants. A few successful treatments have been described in the literature. In our report, we present a biopsy-proven trichodysplasia spinulosa case in a kidney transplant recipient who rapidly responded to a reduction of his immunosuppressive therapy.

show abstract

“…In addition, the patient presented with a rare keratosis pilaris-like eruption on her upper extremities that is uncommon in most TS cases. 39 Frigerio et al 40 reported another case of a TS patient with highrisk pre-B acute lymphoblastic leukemia presenting with trunk and extremity keratosis pilaris-like symptoms (Table 1). Interestingly, the patient's flares seemed to occur more often after methotrexate.…”

Section: Epidemi Ologymentioning

confidence: 99%

Recent developments in trichodysplasia spinulosa disease

Narayanan

Rády

Tyring

2020

Transplant Infectious Dis

View full text Add to dashboard Cite

Trichodysplasia Spinulosa (TS) is a rare proliferative skin disease that occurs primarily in immunocompromised patients, specifically organ transplant recipients. TS is characterized by uncontrolled inner root sheath cell proliferation and folliculocentric papular eruption that can progress to disfiguring leonine facies when left untreated. TS presents with distinct histological features including the presence of large eosinophilic, trichohyaline granules within hyperproliferating inner root sheath cells of the hair bulb. The discovery of the Trichodysplasia Spinulosa Polyomavirus (TSPyV) and recent studies highlighting the role of TSPyV tumor antigens in cell proliferation pathways have provided new insight into the mechanisms of TS development. In this review, we discuss the expansion of our understanding of TS, specifically over the past 5 years. We summarize novel cases of TS and recent developments in the mechanisms underlying TSPyV-mediated disease progression. We also evaluate advancements in diagnostic methods and treatment options. As the incidence of TS continues to rise, it is becoming critical for clinicians to understand the clinical features of TS and emerging research regarding pathogenesis and therapeutics for early treatment of this potentially disfiguring disease.

show abstract

Widespread keratosis pilaris–like eruption in an immunocompromised child

Cited by 6 publications

References 10 publications

Pediatric trichodysplasia spinulosa: A report of 2 cases and review of the literature

Pediatric trichodysplasia spinulosa: A report of 2 cases and review of the literature

Trichodysplasia spinulosa in a renal transplant patient: A case report of successful treatment

Recent developments in trichodysplasia spinulosa disease

Contact Info

Product

Resources

About