Widespread granuloma annulare and Hodgkin's disease

Dadban, A.; Slama, Borhane; Azzedine, A.; Lepeu, G.

doi:10.1111/j.1365-2230.2008.02730.x

Cited by 27 publications

(19 citation statements)

References 11 publications

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“…It has been suggested that GA arises from an immunological reaction to an unidentified antigen 6. In delayed-type hypersensitivity reactions, Th1 cells secrete IFN-γ and macrophage inhibitory factor, leading to monocyte accumulation and degradation of connective tissue by lysosomal enzymes 2.…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic granulomatous dermatitis in a patient with Hodgkin’s disease: a diagnostic pitfall

Tabata¹,

Novoa

Martires

2018

BMJ Case Reports

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The association of malignant lymphomas with non-necrotic epithelioid granulomas has been reported rarely since 1977. Hodgkin's disease-associated widespread cutaneous granuloma annulare (GA) has been reported in only eight patients. We report the second case of subcutaneous GA associated with Hodgkin's disease. A 73-year-old man with Epstein-Barr virus-associated Hodgkin's lymphoma and paraneoplastic subcutaneous GA, presented 3 months after the diagnosis of malignancy. Examination revealed a large, broad erythematous, indurated, subcutaneous plaque spanning the majority of the left lower back and flank with no associated symptoms. Initial biopsy was suggestive of morphea. Prompted by positron emission tomography (PET) findings of increased fluorodeoxyglucose (FDG) uptake, a second, deeper biopsy was performed, revealing subcutaneous palisaded granulomatous dermatitis. After complete workup, the diagnosis most strongly suggested subcutaneous GA. This case highlights the importance of deep incisional biopsies, the fluorodeoxyglucose - positron emission tomography (FDG-PET) findings in GA and the rare association of GA with Hodgkin's disease which may signal the presence of malignancy.

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Section: Discussionmentioning

confidence: 99%

Paraneoplastic granulomatous dermatitis in a patient with Hodgkin’s disease: a diagnostic pitfall

Tabata¹,

Novoa

Martires

2018

BMJ Case Reports

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“…Hematologic malignancies are the most frequently reported. Both Hodgkin [49][50][51][52][53][54] and non-Hodgkin 49,55-57 lymphoma and leukemias [58][59][60][61] have been reported in patients with GA. Solid tumors have also been reported, however, in association with GA.…”

Section: Systemic Associationsmentioning

confidence: 99%

Granuloma Annulare

Keimig

2015

Dermatologic Clinics

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Granuloma annulare (GA) is a noninfectious granulomatous skin condition that can present with a variety of cutaneous morphologies. It is characterized by collagen degeneration, mucin deposition, and palisaded or interstitial histiocytes. Although the mechanism underlying development of GA is unknown, studies point to a cell-mediated hypersensitivity reaction to an as-yet undetermined antigen. Systemic associations with diabetes, thyroid disorders, lipid abnormalities, malignancy, and infection are described in atypical GA. Treatment is divided into localized skin-directed therapies and systemic immunomodulatory or immunosuppressive therapies. The selected treatment modality should be based on disease severity, comorbid conditions, consideration of potential side effects, and patient preference.

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“…The coexistent neoplasms included carcinomas, lymphomas, and acute myeloid leukemia, while separate manuscripts described additional cases of GA in patients with schwannoma, [12] visceral malignancy, [13] Hodgkin disease, [14] and chronic myelomonocytic leukemia. [15] While Li et al [11] found no definite relationship between GA and malignancy, they suggest the investigation of underlying malignancies particularly for older patients with skin lesions that histologically, but not necessarily clinically, resemble GA.…”

Section: Is Granuloma Annulare Associated With Hematopoietic and Solimentioning

confidence: 99%

Non-Infectious Granulomatous Diseases of the Skin and their Associated Systemic Diseases

Hawryluk

Izikson

English

2010

American Journal of Clinical Dermatology

109

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Non-infectious granulomatous diseases of the skin are a broad group of distinct reactive inflammatory conditions that share important similarities. As a group, they are relatively difficult to diagnose and distinguish both clinically as well as histologically. Many of these disorders have significant associations with systemic diseases that impact the patient's overall prognosis. In this update, we offer a discussion of emerging concepts and controversies in this field, as presented through evidence-based answers to seven important clinical questions regarding palisading and epithelioid granulomata. These questions offer an opportunity to review ten non-infectious granulomatous conditions that have implications for systemic disease: granuloma annulare, annular elastolytic giant cell granuloma, necrobiosis lipoidica, methotrexate-induced accelerated rheumatoid nodulosis, necrobiotic xanthogranuloma, interstitial granulomatous dermatitis, interstitial granulomatous drug reaction, palisaded neutrophilic granulomatous dermatitis, sarcoidosis, and metastatic Crohn disease. Recent clinical, epidemiologic, and laboratory studies have shed some light on these diseases, the association of these conditions with systemic disorders, and their overall prognoses.

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Widespread granuloma annulare and Hodgkin's disease

Cited by 27 publications

References 11 publications

Paraneoplastic granulomatous dermatitis in a patient with Hodgkin’s disease: a diagnostic pitfall

Paraneoplastic granulomatous dermatitis in a patient with Hodgkin’s disease: a diagnostic pitfall

Granuloma Annulare

Non-Infectious Granulomatous Diseases of the Skin and their Associated Systemic Diseases

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