Widespread anthelmintic resistance in European farmed ruminants: a systematic review

Rose, Hannah; Rinaldi, Laura; Bosco, Antonio; Mavrot, Fabien; Waal, Theo de; Skuce, Philip; Charlier, Johannes; Torgerson, Paul R.; Hertzberg, Hubertus; Hendrickx, Guy; Vercruysse, Jozef; Morgan, Eric R.

doi:10.1136/vr.102982

Cited by 157 publications

(151 citation statements)

References 19 publications

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“…This common and standardised database is useful to develop cost-efficient sustainable sampling strategies, and multi-scale spatial models for parasite occurrence, including the impact of climate change and anthelmintic resistance in livestock in Europe (Bolajoko et al, 2015;Rose et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…It is a highly pathogenic, blood-feeding helminth that not only cause anaemia, but often also death in heavily infected animals (Burke et al, 2007). H. contortus has a very high propensity to develop resistance to anthelmintics (Kaplan et al, 2004) and drug resistance has been reported in farmed ruminants across Europe (reviewed in Rose et al, 2015). Geographically, it is widely distributed in tropical (between latitudes 23.5 N and 23.5 S) as well as various subtropical climate zones (O'Connor et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Haemonchus contortus: spatial risk distribution for infection in sheep in Europe

et al. 2015

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Abstract.Haemonchus contortus is a species of gastrointestinal strongyles of primary concern for sheep. This highly pathogenic, blood-feeding helminth negatively influences animal health, welfare and productivity. In order to elucidate the current scenario in terms of prevalence and intensity of H. contortus infection in sheep farms across Europe, a standardized crosssectional survey was conducted in three pilot areas in Ireland, Switzerland and Italy, all part of the EU funded GLOWORM project. Two consecutive field surveys (in 2012 and 2013) were conducted in the three countries in the same period (AugustOctober) in 259 sheep farms in total. Harmonized, diagnostic procedures (from farm to laboratory) based on pooled samples, the FLOTAC technique and coproculture were used. The georeferenced parasitological results were modelled (at the pilot area level) following a Bayesian geostatistical approach with correction for preferential sampling and accounting for climatic and environmental covariates. The observed H. contortus prevalence rates did vary between the countries showing high values in Switzerland (77%) and Italy (73%) compared to Ireland (4%). Spatial patterns of H. contortus distribution were detected in Switzerland and Italy with a north-south gradient. The latent factor analysis highlighted the importance of seasonality and annual cyclicity within country (particularly in southern Italy), while mean temperature and rainfall dominated between country variations in the prevalence of H. contortus infection.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Haemonchus contortus: spatial risk distribution for infection in sheep in Europe

et al. 2015

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“…Increasing issues of anthelmintic resistance (AR) are encountered in tropical countries (Almeida et al 2010;Mahieu et al 2014), but recent studies demonstrated that most European countries were more and more facing this issue (Rose et al 2015). In almost all sheep markets in Europe, AR to benzimidazoles (BZ) has been described (Papadopoulos et al 2012); however, ivermectin (IVM) and moxidectin (MOX) resistances are still less frequent in Europe than in the southern hemisphere with the noticeable exception of the UK (Bartley et al 2006) and Ireland (Keane et al 2014).…”

Section: Introductionmentioning

confidence: 99%

A real-time PCR approach to identify anthelmintic-resistant nematodes in sheep farms

et al. 2017

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Resistance to fenbendazole, ivermectin, and moxidectin was explored by a fecal egg count reduction test in four meat sheep flocks in southwestern France where anthelmintic resistance was suspected. The FECR test results of the present study confirmed the presence of benzimidazole resistance in three out of the four farms and the presence of ivermectin resistance in one flock. In addition, a suspicion of moxidectin resistance was shown in this latter farm. Both conventional morphological and molecular identifications were performed on larval cultures before and after the treatment in the studied farms. A high positive correlation was found between the number of larvae counted under binocular microscope and the number of larvae estimated by the qPCR analysis (R 2 = 0.88) and a high Cohen's Kappa value (0.91) in the detection of strongylid larvae in larval cultures. According to qPCR results, Trichostrongylus species demonstrated high levels of BZ resistance and Teladorsagia circumcincta was involved in the IVM resistance in one farm. The molecular procedures used in this study have the potential to be beneficial for anthelmintic resistance surveillance in sheep industry.

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“…O método amplamente utilizado para controle das endoparasitoses é a administração de anti-helmíntico, em muitos casos, indiscriminadamente, o que vem fazendo com que os endoparasitas gastrintestinais se tornem resistentes aos diversos princípios ativos utilizados na formulação de tais fármacos, deixando os animais mais susceptíveis às infestações parasitárias (AMARANTE, 2014;PLAYFORD et al, 2014;ROSE et al, 2015) e fazendo com que este tipo de tratamento se torne cada vez menos eficiente. De acordo com , o desenvolvimento da resistência anti-helmíntica dos vermes foi uma consequência da forte pressão de seleção sobre a população parasitária, devido a utilização indiscriminada de anti-helmínticos.…”

Section: Endoparasitos Gastrintestinais Em Ovinosunclassified

“…Este gênero possui hábito alimentar hematófago e a lesão sanguínea provocada pelo parasita resulta em um estado anêmico . O método amplamente utilizado para controle das endoparasitoses é a administração de anti-helmínticos quimioterápicos, em muitos casos, indiscriminadamente, o que conduz ao desenvolvimento da resistência dos endoparasitas a esses medicamentos (AMARANTE, 2014;PLAYFORD et al, 2014;ROSE et al, 2015).…”

Section: Introductionunclassified

Critérios de seleção para características de importância econômica em ovinos da raça Santa Inês

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Widespread anthelmintic resistance in European farmed ruminants: a systematic review

Cited by 157 publications

References 19 publications

Haemonchus contortus: spatial risk distribution for infection in sheep in Europe

Haemonchus contortus: spatial risk distribution for infection in sheep in Europe

A real-time PCR approach to identify anthelmintic-resistant nematodes in sheep farms

Critérios de seleção para características de importância econômica em ovinos da raça Santa Inês

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