Wide spectrum of novel and rare hemoglobin variants in the multi‐ethnic Indian population: A review
Pallavi Thaker,
Namrata Mahajan,
Malay B. Mukherjee
et al.
Abstract:The hemoglobin (Hb) variants are qualitative abnormalities due to production of structurally abnormal globin proteins. They are categorized based on the type of mutation present in the α1, α2, β, Gγ, Aγ and δ globin genes. So far, more than 1550 Hb variants are reported in the database. They could lead to Hb polymerization, Hb instability, altered oxygen affinity and decreased oxygen‐carrying capacity of Hb or have no clinical manifestations. In India, ethnic diversity, consanguinity, regional variations and m… Show more
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