Abstract:Very few developments in the management of human malignancies have been as controversial as the role of locoregional (wide-field) radiotherapy (RT) in the adjuvant therapy of early breast cancer. This is mostly due to the fact that older trials using more obsolete radiation equipment and treatment planning, while showing a significant reduction of locoregional recurrences, indicated only a moderate improvement of systemic metastases. Also, because of cardiac toxicity, increased cardiovascular mortality counter… Show more
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