Wide dynamic range phase-sensitive surface plasmon resonance biosensor based on measuring the modulation harmonics

Law, Wing Cheung; Markowicz, Przemyslaw P.; Yong, Ken‐Tye; Roy, Indrajit; Baev, Alexander; Patskovsky, Sergiy; Kabashin, Andrei V.; Ho, Ho Pui; Prasad, Paras N.

doi:10.1016/j.bios.2007.07.015

Cited by 59 publications

(33 citation statements)

References 17 publications

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“…It was discovered that these two signals are affected by two different properties of the optical beam, the former predominantly by the polarization amplitude and the latter by the phase. By utilizing these two characteristics, the developed system is able to detect a very small change of refractive index over a wide dynamic range [78].…”

Section: Spr Biosensor With Functionalized Au Npsmentioning

confidence: 99%

A Review on Functionalized Gold Nanoparticles for Biosensing Applications

et al. 2011

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Nanoparticle technology plays a key role in providing opportunities and possibilities for the development of new generation of sensing tools. The targeted sensing of selective biomolecules using functionalized gold nanoparticles (Au NPs) has become a major research thrust in the last decade. Au NP-based sensors are expected to change the very foundations of sensing and detecting biomolecules. In this review, we will discuss the use of surface functionalized Au NPs for smart sensor fabrication leading to detection of specific biomolecules and heavy metal ions.

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Section: Spr Biosensor With Functionalized Au Npsmentioning

confidence: 99%

A Review on Functionalized Gold Nanoparticles for Biosensing Applications

et al. 2011

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“…Thus, it is quite difficult to pick up useful information from the phase of the TE 0 component. In practical experiments, we employ a phase detection scheme using a photo-elastic modulator (PEM) [16,17], for example, in which the signal from the PEM is stable enough as a reference in phase modulation measurement.…”

Section: Deeper Discussionmentioning

confidence: 99%

A Grating-Based Plasmon Biosensor With High Resolution

Luo¹,

Suyama²,

Xu³

et al. 2011

PIER

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Abstract-We present an idea of grating-based plasmon biosensor utilizing phase detection to realize high resolution in finding a refractive index of a material put on the surface of a metal grating. Considering a trade-off between high resolution and experimental practicability, we show a table of recommended setup that covers a wide range of the index. Keeping the diffraction efficiency no less than 10 −3 and assuming the resolution in phase detection to be 2.5 × 10 −2 degrees, we estimate the resolution of the biosensor as 7.5×10 −7 refractive index units. We also discuss the possible improvement to realize a predicted superior limit of resolution around 10 −8 refractive index units.

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“…The SPR and SPRI biosensors have been applied in molecular biology for the detection of proteins with a LOD ranging from picomolar to nanomolar [235][236][237][238][239][240], and detection of DNA molecules [130,[241][242][243] with the LOD as low as 54 fM with a flow injection device and as low as 1 fM when aided by signal amplification through gold nanoparticles [147,244]. Most of them are based on prism coupling design, such as Biocore series (Biocore X to Biocore 4000), SR series (7000 and 7500), Autolab SPR, Plasmonic, Spreeta, Nanofilm, Multiskop.…”

Section: Closing Remarks and Conclusionmentioning

confidence: 99%

Surface plasmon resonance based biosensor technique: A review

Guo

2012

Journal of Biophotonics

381

223

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Optical Surface plasmon resonance (SPR) biosensors represent the most advanced and developed optical label‐free biosensor technology. Optical SPR biosensors are a powerful detection and analysis tool that has vast applications in environmental protection, biotechnology, medical diagnostics, drug screening, food safety and security. This article reviews the recent development of SPR biosensor techniques, including bulk SPR and localized SPR (LSPR) biosensors, for detecting interactions between an analyte of interest in solution and a biomolecular recognition. The concepts of bulk and localized SPs and the working principles of both sensing techniques are introduced. Major sensing advances on biorecognition elements, measurement formats, and sensing platforms are presented. Finally, the discussions on both biosensor techniques as well as comparison of both SPR sensing techniques are made. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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Wide dynamic range phase-sensitive surface plasmon resonance biosensor based on measuring the modulation harmonics

Cited by 59 publications

References 17 publications

A Review on Functionalized Gold Nanoparticles for Biosensing Applications

A Review on Functionalized Gold Nanoparticles for Biosensing Applications

A Grating-Based Plasmon Biosensor With High Resolution

Surface plasmon resonance based biosensor technique: A review

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