Wide-beam reconstruction half-time SPECT improves diagnostic certainty and preserves normalcy and accuracy: A quantitative perfusion analysis

Druz, Regina S.; Phillips, Lawrence M.; Chugkowski, Michelle; Boutis, Loukas; Rutkin, Bruce; Katz, Stanley

doi:10.1007/s12350-010-9304-5

Cited by 29 publications

(23 citation statements)

References 13 publications

(12 reference statements)

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“…The producers of software implemented this method to reconstruction software packages, some of them as a part of software dedicated to particular gamma cameras (GE Healthcare "Evolution for Cardiac", Siemens "Flash3D", Philips "Astonish", Digirad "nSPEED"), another ones as standalone implementations (UltraSPECT "WBR", Hermes Medical Solutions "Hybrid Recon -Cardiology"). In the present work, as in most communications concerning this topic [6][7][8][9], shortening of acquisition time was used as a method for reduction of counts in projection images. Some authors [10] attained reduction of counts by lowering of activity of administered radiopharmaceutical.…”

Section: Discussionmentioning

confidence: 99%

Comparison of shortened gated myocardial perfusion imaging processed with „Myovation Evolution” with full time study

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Comparison of shortened gated myocardial perfusion imaging processed with „Myovation Evolution” with full time study

et al. 2017

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“…Previous studies on dose reductions from half-time or quarter-time imaging were mostly derived from and supported by the wide-beam SPECT reconstruction (26)(27)(28) in which conventional rotating cameras are used and images are reconstructed without CT-based AC. In the present study, however, we used a hybrid SPECT/CT system with stationary CZT SPECT detectors, and the images were reconstructed via the iterative maximum-likelihood expectation maximization algorithm with CT-based AC.…”

Section: Discussionmentioning

confidence: 99%

High-Sensitivity and High-Resolution SPECT/CT Systems Provide Substantial Dose Reduction Without Compromising Quantitative Precision for Assessment of Myocardial Perfusion and Function

2016

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There is increasing concern about radiation exposure from myocardial perfusion SPECT (MPS). γ-cameras with solid-state cadmiumzinc-telluride (CZT) detectors have better count sensitivity and spatial resolution than conventional sodium iodine detectors, allowing for significant reductions in radiotracer dose or acquisition time. This study aimed to demonstrate the capability of a hybrid CZT SPECT/ 64-slice CT system for dose reduction and to determine the maximal reduction possible without compromising image quality or the quantification precision of clinical MPS. Methods: The imaging data of patients with normal myocardial perfusion and 30 patients with midsized to large perfusion defects who had undergone stress 99m Tctetrofosmin MPS were postprocessed. Low-dose (361 ± 60 MBq) and high-dose (725 ± 142 MBq) 99m Tc-tetrofosmin scans were included, with 6-min and 4-min scanning times, respectively. List-mode SPECT data were reconstructed with CT-based attenuation correction and with full as well as 50% and 75% reductions in acquisition time to simulate the corresponding relative dose reductions. The reconstructed SPECT images were analyzed to calculate global MPS defect size and regional defect size for 3 coronary artery territories-left anterior descending, left circumflex, and right-as well as left ventricular (LV) volume and ejection fraction. Results: For patients with normal MPS results, there were no differences in defect size, LV volume, or ejection fraction, regardless of whether 50% or 75% reduction was used. For patients with abnormal MPS results, at a 50% reduction there was a significant difference in global defect size but not in regional defect size in the left anterior descending, left circumflex, and right coronary artery territories, whereas at a 75% reduction the difference was statistically significant in all territories, including the difference in global defect size. Nonetheless, differences in the defect size were minimal. The LV end-diastolic and end-systolic volumes and LV ejection fraction were not significantly different, regardless of whether 50% or 75% dose reduction was used. Conclusion: Ultra-low-dose (,190 MBq) MPS even with short imaging times (,6 min) is feasible using a hybrid CZT SPECT/CT camera without compromising image quality or significantly altering quantification of myocardial perfusion or LV function. We demonstrated that an additional 50% reduction in the current low-dose recommendations from the American Society of Nuclear Cardiology guidelines for 99m Tc-labeled MPS is highly feasible while retaining short imaging protocols. SPECTwi th 99m Tc-labeled radiotracers has been widely used for the detection of abnormalities of myocardial perfusion and left ventricular (LV) function (1-9). Hybrid SPECT/CT systems equipped with a multislice CT component allowing for precise attenuation correction (AC) (10-12) have been used routinely in nuclear cardiac imaging for more than a decade. Although this imaging modality is well recognized to provide invaluable diagnostic information...

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“…17 In another clinical trial it was shown that adaptive noise control with WBR improves uniformity of myocardium compared to FBP techniques, and results in improved diagnostic certainty while preserving normalcy and accuracy. 20 In yet another large multicenter trial using half-time upright SPECT acquisition reconstructed with another version of resolution recovery, it was shown this methodology yielded results similar to conventional full acquisition times without compromising perfusion and function information. In general, it can be concluded from the results of these and other clinical trials that half time acquisitions reconstructed with resolution recovery improve image quality over FBP or standard OSEM and provide perfusion information, which is very similar to FBP.…”

Section: Clinical Trialsmentioning

confidence: 98%

Advances in Software for Faster Procedure and Lower Radiotracer Dose Myocardial Perfusion Imaging

Piccinelli

Garcia

2015

Progress in Cardiovascular Diseases

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Wide-beam reconstruction half-time SPECT improves diagnostic certainty and preserves normalcy and accuracy: A quantitative perfusion analysis

Abstract: Quantitative perfusion analysis suggests that adaptive noise control with WBR improves uniformity of myocardium comparing to FBP techniques, and results in improved diagnostic certainty while preserving normalcy and accuracy.

Cited by 29 publications

References 13 publications

Comparison of shortened gated myocardial perfusion imaging processed with „Myovation Evolution” with full time study

Comparison of shortened gated myocardial perfusion imaging processed with „Myovation Evolution” with full time study

High-Sensitivity and High-Resolution SPECT/CT Systems Provide Substantial Dose Reduction Without Compromising Quantitative Precision for Assessment of Myocardial Perfusion and Function

Advances in Software for Faster Procedure and Lower Radiotracer Dose Myocardial Perfusion Imaging

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