Wide-angle X-ray scattering as a probe for insulin denaturation

Elshemey, Wael M.; Mohammad, Ibtesam A.; Elsayed, Ashraf

doi:10.1016/j.ijbiomac.2010.03.011

Cited by 12 publications

(6 citation statements)

References 44 publications

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“…Zinc-free insulin is a dimer over pH range 2-8; 20% acetic acid or ethanol at pH 2 dissociates insulin to monomers. Insulin is susceptible to forming ␤-sheet-rich fibrils upon exposure to elevated temperatures, low pH, and agitation [9][10][11]. The addition of organic solvents, such as ethyl acetate, dimethylsulfoxide [12], and tannic acid [13], however, precipitates insulin from aqueous solutions as globular aggregates [14].…”

Section: Introductionmentioning

confidence: 99%

Investigation into the mechanism of (−)-epigallocatechin-3-gallate-induced precipitation of insulin

Wang

Dong

Sun

2012

International Journal of Biological Macromolecules

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Section: Introductionmentioning

confidence: 99%

Investigation into the mechanism of (−)-epigallocatechin-3-gallate-induced precipitation of insulin

Wang

Dong

Sun

2012

International Journal of Biological Macromolecules

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“…The device uses a Cu target (size 12 mm × 0.4 mm) to produce collimated X-ray energy of 8.047 keV. Measurements were carried out in a step mode at a step size of 0.5°in an angular range from 2θ = 10 ° to 80 °with a step time of 20 s. Diffraction data were collected using a PW 3011/10 proportional detector with a graphite monochromator [21,22].…”

Section: B X-ray Diffractionmentioning

confidence: 99%

Investigation of Bismuth Nano-Bioactive Glass Doped Iron Oxide Formation and Structure Properties on Biocompatibility

Kenawy

Ghazala

Shinawy

et al. 2023

Preprint

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A novel nano-sized bismuth oxide bioglass doped iron oxide were synthesized through a sol-gel technique showed in graphical abstract. Bioactivity was investigated by in-vitro synthesis involving immersion of the samples in simulated body fluid (SBF) for different time intervals. XRD, FTIR, Fe57 Mössbauer spectroscopy, SEM, EDX and DLS were used to characterization of prepared bioglass. Results showed that Fe ions migrated into the glass matrix much faster than Si ions moved into the samples with iron content, especially with higher iron content. The experiment of co-culturing cells with BG showed that osteoblast-like MC3T3-E1 cells could attach well to the surface of BG, especially which contain iron content. Prepared material has the potential may be suitable for serving as a material to improve osteogenesis or thermoseeds targeted drug delivery of Fe-bioglass implants.

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“…The device uses a Cu target (size 12 mm×0.4 mm) to produce collimated X-ray energy of 8.047 keV. Measurements were carried out in a step mode at a step size of 0.5°in an angular range from 2θ=5 °to 80 °with a step time of 20 s. Diffraction data were collected using a PW 3011/10 proportional detector with a graphite monochromator [40,41].…”

Section: X-ray Diffractionmentioning

confidence: 99%

Enhancement of mechanical properties of chitosan film by doping with sage extract-loaded niosomes

Abd-Elghany

Mohamad

El-Sakhawy

et al. 2022

Mater. Res. Express

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Chitosan films are increasingly being applied in the biomedical field owing to their biocompatibility, biodegradability, non-toxicity, mucoadhesive nature, hemostatic properties, antibacterial and biological activities. This study aimed to enhance the mechanical properties of chitosan films by doping niosomal sage nanoparticles (NS-SagNPs) at various concentrations (100-300 μg). The NS-SagNPs were prepared by a thin-film hydration process with an average particle size of 21.5 nm. The doped chitosan films were fabricated through a simple casting method. FTIR and DSC measurements confirmed the successful incorporation of NS-SagNPs in the chitosan films. The mechanical properties of the doped films were improved and the most significant improvement was found in tensile strength and elasticity when the NS-SagNPs loading was increased to 300 μg. Based on these results, chitosan films doped with NS-SagNPs have the advantageous feature of sage and show enhanced mechanical properties compared with pure chitosan, rendering them more suitable for biomedical applications.

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Wide-angle X-ray scattering as a probe for insulin denaturation

Cited by 12 publications

References 44 publications

Investigation into the mechanism of (−)-epigallocatechin-3-gallate-induced precipitation of insulin

Investigation into the mechanism of (−)-epigallocatechin-3-gallate-induced precipitation of insulin

Investigation of Bismuth Nano-Bioactive Glass Doped Iron Oxide Formation and Structure Properties on Biocompatibility

Enhancement of mechanical properties of chitosan film by doping with sage extract-loaded niosomes

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