Why the yew tree (Taxus Baccata) is not attacked by insects

Daniewski, W. M.; Gumulka, M.; Anczewski, Waldemar; Masnyk, Marek; Bloszyk, E.; Gupta, K. K.

doi:10.1016/s0031-9422(98)00102-2

Cited by 34 publications

(28 citation statements)

References 10 publications

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“…Such practices have been suggested for the Final Neolithic occupation of Horgen Scheller (Zü rich, Switzerland), where an important quantity of yew branches was associated with sheep/goats penning area (Favre and Jacomet, 1998). The presence of yew could also be related to its insecticide, fungicide and antimicrobial properties (Erdemoglu and Sener, 2001;Daniewski et al, 1998).…”

Section: Targeted Gatherings For Special Uses?mentioning

confidence: 99%

Shepherds and plants in the Alps: multi-proxy archaeobotanical analysis of neolithic dung from “La Grande Rivoire” (Isère, France)

Delhon

Martin

Argant

et al. 2008

Journal of Archaeological Science

114

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a b s t r a c tThe analysis of phytoliths, pollen, charcoal and other macroremains was carried out in the neolithic shelter of ''La Grande Rivoire'', Vercors massif (French Alps). The results show the predominance of tree species, in the form of phytoliths, clustered pollen, stomata, small branches charcoal, needles, bark, buds. The practice of leaf fodder is already known in the alpine and circum-alpine area from archaeological and historical sources. The analyses of the neolithic dung levels of ''La Grande Rivoire'' illustrate the use of leafy and flowering tree branches as fodder. The results also suggest that some species were used for special purpose in relation with the tending of livestock (litter, dietary supplement, veterinary practices).

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Section: Targeted Gatherings For Special Uses?mentioning

confidence: 99%

Shepherds and plants in the Alps: multi-proxy archaeobotanical analysis of neolithic dung from “La Grande Rivoire” (Isère, France)

Delhon

Martin

Argant

et al. 2008

Journal of Archaeological Science

114

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“…Foram isoladas nove substâncias (81-89) (Figura 10), a maioria com esqueleto taxano, sendo que a 10-desacetilbacatina III (81) e V (82) mostraram-se fortemente ativas, seguidas pelos derivados da taxicina 83 e 84, moderadamente ativos. Os compostos fenólicos 88 e 89 foram os menos ativos 37,40 .…”

Section: Monoterpenos E Sesquiterpenosunclassified

Terpenos com atividade inseticida: uma alternativa para o controle químico de insetos

Júnior¹

2003

Quím. Nova

153

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“…A variety of taxoids have antifeedant (Daniewski et al 1998) or antibiotic activity (Elmer et al 1994), or are toxic to mammals, and thus are thought to play a role in plant defense (Odgen 1988). Taxoid hydroxylase genes of yew are inducible by treatment with methyl jasmonate or fungal elicitors (Yuan et al 2002;Chen et al 1999), consistent with a role in defense and suggestive that this evolutionary pressure has driven taxoid metabolic complexity in this long-lived species.…”

Section: Characteristics and Evolutionally Origins Of The Taxane Oxygmentioning

confidence: 99%

Cytochrome P450 oxygenases of Taxol biosynthesis

2006

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Cytochrome P450 monooxygenases play a prominent role in the biosynthesis of the diterpenoid anticancer drug Taxol, as they appear to constitute about half of the 19 enzymatic steps of the pathway in yew (Taxus) species. A combination of classical biochemical and molecular methods, including cell-free enzyme studies and differential-display of mRNA-reverse transcription polymerase chain reaction (RT-PCR) combined with a homology-based searching and random sequencing of a cDNA library from induced T. cuspidata cells, led to the discovery of six novel cytochrome P450 taxoid (taxane diterpenoid) hydroxylases. These genes show unusually high sequence similarity with each other (>70%) but low similarity (<30%) to, and significant evolutionary distance from, other plant P450s. Despite their high similarity, functional analysis of these hydroxylases demonstrated distinctive substrate specificities responsible for an early bifurcation in the biosynthetic pathway after the initial hydroxylation of the taxane core at C5, leading into a biosynthetic network of competing, but interconnected, branches. The use of surrogate substrates, in cases where the predicted taxoid precursors were not available, led to the discovery of two core oxygenases, the 2α-and the 7β-hydroxylase. This general approach could accelerate the functional analysis of candidate cDNAs from the extant family of P450 genes to identify the remaining oxygenation steps of this complex pathway.

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Why the yew tree (Taxus Baccata) is not attacked by insects

Cited by 34 publications

References 10 publications

Shepherds and plants in the Alps: multi-proxy archaeobotanical analysis of neolithic dung from “La Grande Rivoire” (Isère, France)

Shepherds and plants in the Alps: multi-proxy archaeobotanical analysis of neolithic dung from “La Grande Rivoire” (Isère, France)

Terpenos com atividade inseticida: uma alternativa para o controle químico de insetos

Cytochrome P450 oxygenases of Taxol biosynthesis

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