Why Is Wnt/β-Catenin Not Yet Targeted in Routine Cancer Care?
Auriane de Pellegars-Malhortie,
Laurence Picque Lasorsa,
Thibault Mazard
et al.
Abstract:Despite significant progress in cancer prevention, screening, and treatment, the still limited number of therapeutic options is an obstacle towards increasing the cancer cure rate. In recent years, many efforts were put forth to develop therapeutics that selectively target different components of the oncogenic Wnt/β-catenin signaling pathway. These include small molecule inhibitors, antibodies, and more recently, gene-based approaches. Although some of them showed promising outcomes in clinical trials, the Wnt… Show more
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