Why Hoffmann? His Chemistry**

Seeman, Jeffrey I.

doi:10.1002/tcr.202200205

Cited by 3 publications

(4 citation statements)

References 131 publications

(340 reference statements)

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“…His Chemistry. [49] So much has already been written about Woodward, even by this author, that Woodward's story could be told in one (granted, rather lengthy and highly illustrated) essay. [47] Hoffmann's story -at least that up to May 5, 1964 -needed two essays.…”

Section: A Summary Of Publications 1-10 In the Wà H Seriesmentioning

confidence: 99%

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Introduction to “The Woodward‐Hoffmann Rules. From May 5, 1964, to November 30, 1964”**

Seeman

2023

The Chemical Record

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An introduction is provided to Publication 11 in the series of articles by the author on the history of the Woodward‐Hoffmann (W−H) rules. Now permanently open access (CC‐BY) at http://pubs.acs.org/doi/abs/10.1021/acs.joc.5b01792, Paper 11 was published in 2015 in The Journal of Organic Chemistry to celebrate the 50th anniversary of the W−H rules. This paper summarizes the content of Publications 1–10 in the series and provides an idea of the major components of Publication 11.

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Section: A Summary Of Publications 1-10 In the Wà H Seriesmentioning

confidence: 99%

“…[44] * Publications 5, [32] 6 [45] and 7 [46] discuss the many chemists who were so very close to discovering the WÀ H rules but did not do so. Publications 8 [47] and 9 (in two parts [48,49] ) discuss the two chemists who did so. Woodward is the focus in the former.…”

Section: A Summary Of Publications 1-10 In the Wà H Seriesmentioning

confidence: 99%

Introduction to “The Woodward‐Hoffmann Rules. From May 5, 1964, to November 30, 1964”**

Seeman

2023

The Chemical Record

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“…While Hoffmann's life was permanently influenced by the murder of his father and many other family members and his own Anne Frank-like experience in the Ukraine during World War II, by the time he had immigrated to the United States and was integrated into its educational system, whatever prejudice he experienced took a back seat to Hoffmann's personal strengths and achievements. [30,31] Thus, unanticipated consequences of World War II included increased funding of science, the dramatic advances soon to be experienced in chemistry, and the influx of intellectual capital from Europe to the United States. Roald Hoffmann was to benefit from this confluence of events.…”

Section: Social Construction Of Sciencementioning

confidence: 99%

Why Woodward and Hoffmann? And Why 1965?**

Seeman

2023

The Chemical Record

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Dedicated to the memory of one of the great collaborations in the history of chemistry, that of R. B. Woodward and Albert Eschenmoser and the total synthesis of vitamin B 12 . [1][2][3][4][5][6][7][8][9][10] Curiously, it was during a failed route to vitamin B 12 by Woodward and Subramania Ranganathan, [11,12] prior to the beginning of the Woodward-Eschenmoser collaboration, that one of the motivating factors for the initiation of another great collaboration was observed, that of Woodward and Roald Hoffmann.

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“…When Hoffmann began his collaboration with Woodward in May 1964, ,− he studied certain valence isomerizations known as “no-mechanism reactions.” − This colloquialism reflects the fact that the reactions have no intermediates or multiple steps, the usual definition of a concerted mechanism. These “no-mechanism reactions” were later named pericyclic reactions , by Woodward and Hoffmann.…”

Section: Reaction Coordinate Diagrams: 1964 To the Presentmentioning

confidence: 99%

A 21st Century View of Allowed and Forbidden Electrocyclic Reactions

Zhou,

Kukier,

Gordiy

et al. 2023

J. Org. Chem.

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In 1965, Woodward and Hoffmann proposed a theory to predict the stereochemistry of electrocyclic reactions, which, after expansion and generalization, became known as the Woodward−Hoffmann Rules. Subsequently, Longuet-Higgins and Abrahamson used correlation diagrams to propose that the stereoselectivity of electrocyclizations could be explained by the correlation of reactant and product orbitals with the same symmetry. Immediately thereafter, Hoffmann and Woodward applied correlation diagrams to explain the mechanism of cycloadditions. We describe these discoveries and their evolution. We now report an investigation of various electrocyclic reactions using DFT and CASSCF. We track the frontier molecular orbitals along the intrinsic reaction coordinate and modeled trajectories and examine the correlation between HOMO and LUMO for thermally forbidden systems. We also investigate the electrocyclizations of several highly polarized systems for which the Houk group had predicted that donor−acceptor substitution can induce zwitterionic character, thereby providing low-energy pathways for formally forbidden reactions. We conclude with perspectives on the field of pericyclic reactions, including a refinement as the meaning of Woodward and Hoffmann's "Violations. There are none!" Lastly, we comment on the burgeoning influence of computations on all fields of chemistry.

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Why Hoffmann? His Chemistry**

Cited by 3 publications

References 131 publications

Introduction to “The Woodward‐Hoffmann Rules. From May 5, 1964, to November 30, 1964”**

Introduction to “The Woodward‐Hoffmann Rules. From May 5, 1964, to November 30, 1964”**

Why Woodward and Hoffmann? And Why 1965?**

A 21st Century View of Allowed and Forbidden Electrocyclic Reactions

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