Why have SGLT2 Inhibitors Failed to Achieve the Desired Success in
COVID-19?
Medine Cumhur Cure,
Erkan Cure
Abstract:Abstract::
The SARS-CoV-2 virus emerged towards the end of 2019 and caused a major worldwide pandemic
lasting at least 2 years, causing a disease called COVID-19. SARS-CoV-2 caused a severe infection with direct
cellular toxicity, stimulation of cytokine release, increased oxidative stress, disruption of endothelial structure,
and thromboinflammation, as well as angiotensin-converting enzyme 2 (ACE2) down-regulation-mediated
renin-angiotensin system (RAS) activation. In addition to glucosuria and natriuresis, … Show more
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