Why genetically modified food need reconsideration before consumption?

Grover, Alka; Ashhar, Nida; Patni, Pranav

doi:10.4103/2249-4863.141597

Cited by 5 publications

(4 citation statements)

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“…No such distal maintenance factors have yet been identified in the mammalian hematopoietic system, although long-range cues, such as estrogen from the ovaries and erythropoietin from the kidneys, can acutely stimulate HSC proliferation and dictate HSC and progenitor differentiation (9,10). Neurotransmitters from the nervous system can mobilize HSCs, but this effect is mediated through mesenchymal stromal cells in the niche (11).…”

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confidence: 99%

Hepatic thrombopoietin is required for bone marrow hematopoietic stem cell maintenance

Decker

Leslie

Liu

et al. 2018

Science

100

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Hematopoietic stem cell (HSC) maintenance depends on extrinsic cues. Currently, only local signals arising from the bone marrow niche have been shown to maintain HSCs. However, it is not known whether systemic factors also sustain HSCs. We assessed the physiological source of thrombopoietin (TPO), a key cytokine required for maintaining HSCs. Using knock-in mice, we showed that TPO is expressed by hepatocytes but not by bone marrow cells. Deletion of from hematopoietic cells, osteoblasts, or bone marrow mesenchymal stromal cells does not affect HSC number or function. However, when is deleted from hepatocytes, bone marrow HSCs are depleted. Thus, a cross-organ factor, circulating TPO made in the liver by hepatocytes, is required for bone marrow HSC maintenance. Our results demonstrate that systemic factors, in addition to the local niche, are a critical extrinsic component for HSC maintenance.

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confidence: 99%

Hepatic thrombopoietin is required for bone marrow hematopoietic stem cell maintenance

Decker

Leslie

Liu

et al. 2018

Science

100

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“…More so, delaying tightened regulation risks facing increased GM plants, including genome-edited crops with deliberately altered and potentially harmful sequences [ 64 , 65 , 66 ]. A call for reconsideration before consumption [ 67 ], problematic and insufficient national legislation [ 68 ], risk of allergenicity [ 69 ] and consumer’s knowledge versus fears [ 70 , 71 ] are increasingly expressed concerning genetically modified food. Table 1 summarizes the harmful MGEs that potentially can compromise public health.…”

Section: Numerous Harmful Mobile Genetic Elements (Mges) Can Be Trans...mentioning

confidence: 99%

“…The same applies to genetically modified food after entering the human body [ 127 ]. Risks to fetuses, plant toxin production, HGT to the enteric microbiome, spreading ARG and MDR delivery and allergenic reaction induction are some of the reported risks [ 67 , 69 , 127 ]. Intriguingly, a comparable risk exists in the usage of engineered fungi [ 128 ].…”

Section: The New Gems Can Change the Long-term Natural Evolution Of T...mentioning

confidence: 99%

“…Transfer of drug resistance Transfer of virulence factors, toxins, ARGs and other detrimental MGEs should be implemented [56][57][58][59][60][61] Interference with the luminal lipid metabolism [62] Genetically modified plants Modified DNA or other MGEs can be laterally transferred to other recipients, spanning prokaryotes, eukaryotes and even people. [1,63] Genome-edited plants, like crops with deliberately altered and potentially harmful sequences, can invade the human microbiome or genome [64][65][66][67][68][69][70][71] GEMs-genetically engineered microorganisms, HGT-horizontal gene transfer, MGEs-mobile genetic elements, mTG-microbial transglutaminase, ARGs-antibiotic resistance genes.…”

Section: Mges Potential Harmful Effects Referencesmentioning

confidence: 99%

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The Potential Harmful Effects of Genetically Engineered Microorganisms (GEMs) on the Intestinal Microbiome and Public Health

Lerner,

Benzvi,

Vojdani

2024

Microorganisms

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Gut luminal dysbiosis and pathobiosis result in compositional and biodiversified alterations in the microbial and host co-metabolites. The primary mechanism of bacterial evolution is horizontal gene transfer (HGT), and the acquisition of new traits can be achieved through the exchange of mobile genetic elements (MGEs). Introducing genetically engineered microbes (GEMs) might break the harmonized balance in the intestinal compartment. The present objectives are: 1. To reveal the role played by the GEMs’ horizontal gene transfers in changing the landscape of the enteric microbiome eubiosis 2. To expand on the potential detrimental effects of those changes on the human genome and health. A search of articles published in PubMed/MEDLINE, EMBASE, and Scielo from 2000 to August 2023 using appropriate MeSH entry terms was performed. The GEMs’ horizontal gene exchanges might induce multiple human diseases. The new GEMs can change the long-term natural evolution of the enteric pro- or eukaryotic cell inhabitants. The worldwide regulatory authority’s safety control of GEMs is not enough to protect public health. Viability, biocontainment, and many other aspects are only partially controlled and harmful consequences for public health should be avoided. It is important to remember that prevention is the most cost-effective strategy and primum non nocere should be the focus.

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