Why drug exposure is frequently associated with T-cell mediated cutaneous hypersensitivity reactions
James Line,
Eleanor Saville,
Xiaoli Meng
et al.
Abstract:Cutaneous hypersensitivity reactions represent the most common manifestation of drug allergy seen in the clinic, with 25% of all adverse drug reactions appearing in the skin. The severity of cutaneous eruptions can vastly differ depending on the cellular mechanisms involved from a minor, self-resolving maculopapular rash to major, life-threatening pathologies such as the T-cell mediated bullous eruptions, i.e., Stevens Johnson syndrome/toxic epidermal necrolysis. It remains a significant question as to why the… Show more
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