Why doesn't Ebola virus cause pandemics like SARS-CoV-2?

Popovic, Marko

doi:10.1016/j.mran.2022.100236

Cited by 22 publications

(25 citation statements)

References 71 publications

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“…where rbs represents biosynthesis rate, while ΔbsG⁰ is standard Gibbs energy of biosynthesis [Popovic, 2022h]. By comparing permissiveness coefficients for two different viruses (or virus variants) for the same host tissue, it is possible to conclude whether during simultaneous contact with both viruses by the same host, there will be coinfection or interference.…”

Section: Discussionmentioning

confidence: 99%

“…To explore the interaction between a virus and its human host, it was necessary to find thermodynamic properties for host organisms. Thermodynamic properties have been reported for human tissues [Popovic and Minceva, 2020c;Popovic, 2022h]. Thermodynamic properties of plant host organisms have been reported in [Popovic and Minceva, 2021b].…”

Section: From Thermodynamics To Biothermodynamicsmentioning

confidence: 99%

“…The permissiveness represents the ability of a virus to multiply inside the host [Hou et al, 2017]. Multiplication of a virus represents a chemical reaction of polymerization of nucleotides into nucleic acids, and amino acids into structural and functional proteins of the virus [Popovic, 2022h]. The driving force for these reactions is Gibbs energy of biosynthesis [Popovic, 2022i].…”

Section: From Thermodynamics To Biothermodynamicsmentioning

confidence: 99%

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Biothermodynamics of Viruses from Absolute Zero (1950) To – Virothermodynamics (2022)

Popovic¹

2022

Preprint

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Biothermodynamics of viruses is among the youngest, but rapidly developing scientific disciplines. During the COVID-19 pandemic, it has closely followed the results published by molecular biologists. Empirical formulas were published for 50 viruses and thermodynamic properties for multiple viruses and virus variants, including all variants of concern of SARS-CoV-2, SARS-CoV, MERS-COV, Ebola virus, Vaccinia and Monkeypox virus. A review of development of biothermodynamics of viruses during the last several decades and intense development during the last 3 years has been described in this paper.

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Section: Discussionmentioning

confidence: 99%

Section: From Thermodynamics To Biothermodynamicsmentioning

confidence: 99%

Section: From Thermodynamics To Biothermodynamicsmentioning

confidence: 99%

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Biothermodynamics of Viruses from Absolute Zero (1950) To – Virothermodynamics (2022)

Popovic¹

2022

Preprint

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“…where CH2O represents a carbohydrate molecule and (Bio) represents the empirical formula of live matter of the human host tissue [Popovic, 2022k]. The ions Na + , K + and Clrepresent the sources of sodium, potassium and chlorine, respectively [Popovic, 2022k].…”

Section: Elemental Composition and Biosynthesis Reactionsmentioning

confidence: 99%

“…muscles, skin, adipose tissues etc.). Thermodynamic properties of biosynthesis for various human tissues are given in [Popovic, 2022k;Popovic and Minceva, 2020c]. It is also necessary to know thermodynamic properties for the virus wild type and for the attenuated strain.…”

Section: Designing An Attenuated Vaccinementioning

confidence: 99%

The Silver Bullet: A Safe and Efficient Attenuated Vaccine for Viral Diseases Based on Biothermodynamics

Popovic¹

2022

Preprint

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Live attenuated vaccines have through history proved themselves as safe and efficient. Pasteur has developed a vaccine against rabies, through a long process of passage of the virus wild type through rabbits. The result was one of the most efficient attenuated live-virus vaccines. This paper suggests a method based on calculations of biothermodynamic properties of potential tissues for vaccine application, predilected host tissue and virus wild type. Gibbs energy of biosynthesis represents the thermodynamic driving force for virus multiplication. The attenuated strain of the virus should possess Gibbs energy of biosynthesis, which is less negative than the predilected target tissue, but more negative than the vaccine portal tissue. In that way, the attenuated virus strain should be able to multiply in the vaccine portal of entry tissue and cause an immune response, making it efficient. On the other hand, the attenuated strain cannot multiply in the predilected host tissue, making it safe. The attenuation is achieved by adding a gene to the virus, which encodes a ballast protein. Production of the ballast protein would make virus multiplication less favorable, since it would require energy, but be useless to the virus.

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Thermodynamics of microbial consortia: Enthalpies and Gibbs energies of microorganism live matter and macromolecules of E. coli, G. oxydans, P. fluorescens, S. thermophilus and P. chrysogenum

Popovic,

Šekularac,

Stevanović

2024

Journal of Biotechnology

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Why doesn't Ebola virus cause pandemics like SARS-CoV-2?

Cited by 22 publications

References 71 publications

Biothermodynamics of Viruses from Absolute Zero (1950) To – Virothermodynamics (2022)

Biothermodynamics of Viruses from Absolute Zero (1950) To – Virothermodynamics (2022)

The Silver Bullet: A Safe and Efficient Attenuated Vaccine for Viral Diseases Based on Biothermodynamics

Thermodynamics of microbial consortia: Enthalpies and Gibbs energies of microorganism live matter and macromolecules of E. coli, G. oxydans, P. fluorescens, S. thermophilus and P. chrysogenum

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